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In this study, four catechol siderphores (1\u20134), including two new ones named serratiochelins E (1) and F (2), were obtained from the fermentation of a mangrove-derived bacterium, S. marcescens F2-2. The structures were elucidated with various spectroscopic methods such as NMR and HR-ESI-MS. Absolute and geometric configurations of the new compounds were established by employing quantum NMR calculations in conjunction with DP4+ probability analysis, ECD calculations, and the advanced Marfey\u2019s method. The bioactivity test showed that serratiochelin B (3) displayed weak but selective cytotoxicity against HepG2 cancer cells with an IC50 of 50.6 \u03bcmol\/L and could trigger apoptosis through both Bcl-2\/Bax\/caspase-3 and Fas\/FasL\/caspase-8 signaling pathways. These findings deepen the understanding of siderophores of S. marcescens and provide a lead for research on anti-liver cancer drugs.<\/jats:p>","DOI":"10.3390\/md23060241","type":"journal-article","created":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T08:34:13Z","timestamp":1748853253000},"page":"241","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Catechol Siderophores from a Mangrove-Derived Bacteria Serratia\u00a0marcescens F2-2 and Their Cytotoxic Activity"],"prefix":"10.3390","volume":"23","author":[{"given":"Gang","family":"Zhang","sequence":"first","affiliation":[{"name":"Engineering Research Center of Marine Biopharmaceutical Resource of Fujian Province University, Xiamen Medical College, Xiamen 361023, China"},{"name":"Xiamen Key Laboratory of Marine Medicinal Natural Product Resources, Xiamen Medical College, Xiamen 361023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xunming","family":"Wang","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Marine Biopharmaceutical Resource of Fujian Province University, Xiamen Medical College, Xiamen 361023, China"},{"name":"Xiamen Key Laboratory of Marine Medicinal Natural Product Resources, Xiamen Medical College, Xiamen 361023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingwang","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Technology, Shandong University, Qingdao 266237, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Ye","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Marine Biopharmaceutical Resource of Fujian Province University, Xiamen Medical College, Xiamen 361023, China"},{"name":"Xiamen Key Laboratory of Marine Medicinal Natural Product Resources, Xiamen Medical College, Xiamen 361023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0929-8421","authenticated-orcid":false,"given":"Longyang","family":"Ke","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Marine Biopharmaceutical Resource of Fujian Province University, Xiamen Medical College, Xiamen 361023, China"},{"name":"Xiamen Key Laboratory of Marine Medicinal Natural Product Resources, Xiamen Medical College, Xiamen 361023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shimin","family":"Fan","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Marine Biopharmaceutical Resource of Fujian Province University, Xiamen Medical College, Xiamen 361023, China"},{"name":"Xiamen Key Laboratory of Marine Medicinal Natural Product Resources, Xiamen Medical College, Xiamen 361023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8987-8746","authenticated-orcid":false,"given":"Xuan","family":"Hong","sequence":"additional","affiliation":[{"name":"Xiamen Key Laboratory of Marine Medicinal Natural Product Resources, Xiamen Medical College, Xiamen 361023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3223-4007","authenticated-orcid":false,"given":"Guoqiang","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7835-4409","authenticated-orcid":false,"given":"Bingye","family":"Yang","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Marine Biopharmaceutical Resource of Fujian Province University, Xiamen Medical College, Xiamen 361023, China"},{"name":"Xiamen Key Laboratory of Marine Medicinal Natural Product Resources, Xiamen Medical College, Xiamen 361023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lianzhong","family":"Luo","sequence":"additional","affiliation":[{"name":"Engineering Research Center of Marine Biopharmaceutical Resource of Fujian Province University, Xiamen Medical College, Xiamen 361023, China"},{"name":"Xiamen Key Laboratory of Marine Medicinal Natural Product Resources, Xiamen Medical College, Xiamen 361023, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,5,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.phytol.2023.07.008","article-title":"Serratiochelin D, a new siderophore from Serratia marcescens","volume":"57","author":"Eze","year":"2023","journal-title":"Phytochem. 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