{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:02:16Z","timestamp":1784127736578,"version":"3.55.0"},"reference-count":73,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T00:00:00Z","timestamp":1750464000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>The Moroccan coastline has been the focus of attention for researchers studying the national algal flora, with the aim of preserving these invaluable natural resources. Since the year 2000, these resources have stimulated great interest in the creation of new drugs, as well as their integration into food supplements and foods. Therefore, this study aims to explore the phytochemistry of a series of extracts derived from Caulerpa prolifera. To ensure better extraction of the various metabolites present, two extraction methods, namely maceration and the Soxhlet method, were employed using solvents of varying polarity (hexane, ethyl acetate, methanol, and water). The chemical composition of the extracts was analyzed using GC-MS for fatty acids and HPLC-DAD for phenolic compounds. Antioxidant activity was evaluated using DPPH and \u03b2-carotene bleaching assays, while antidiabetic potential was assessed by in vitro inhibition of \u03b1-amylase and \u03b1-glucosidase. In addition, Molecular docking models were employed to assess the interaction between the bioactive molecules and the human pancreatic \u03b1-amylase and \u03b1-glucosidase enzymes. Vanillin, p-coumaric acid, sinapic acid, 7,3\u2032,4\u2032-flavon-3-ol, and kaempferol were the most abundant phenolic compounds. Anti-diabetic and antioxidant effects were highly significant.<\/jats:p>","DOI":"10.3390\/md23070259","type":"journal-article","created":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T04:50:05Z","timestamp":1750654205000},"page":"259","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["A Comparative Study of the Phytochemical Composition, Antioxidant Properties, and In Vitro Anti-Diabetic Efficacy of Different Extracts of Caulerpa prolifera"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5043-3838","authenticated-orcid":false,"given":"Safae","family":"Ouahabi","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Pharmacy of Oujda, Mohammed First University, 724, Oujda 60000, Morocco"},{"name":"Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, BP 717, Oujda 60000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3516-318X","authenticated-orcid":false,"given":"Nour Elhouda","family":"Daoudi","sequence":"additional","affiliation":[{"name":"Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, BP 717, Oujda 60000, Morocco"},{"name":"Higher Institute of Nursing Professions and Health Techniques, Oujda 60000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6614-9594","authenticated-orcid":false,"given":"Mohamed","family":"Chebaibi","sequence":"additional","affiliation":[{"name":"Ministry of Health and Social Protection, Higher Institute of Nursing Professions and Health Techniques, Fez 30000, Morocco"},{"name":"Biomedical and Translational Research Laboratory, Faculty of Medicine and Pharmacy of Fez, Sidi Mohamed Ben Abdellah University, Fez 30000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8846-6299","authenticated-orcid":false,"given":"Ibrahim","family":"Mssillou","sequence":"additional","affiliation":[{"name":"National Agency of Medicinal and Aromatic Plants, BP 159, Principal, Taounate 34000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilyesse","family":"Rahhou","sequence":"additional","affiliation":[{"name":"Higher Institute of Nursing Professions and Health Techniques, Oujda 60000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Bnouham","sequence":"additional","affiliation":[{"name":"Laboratory of Bioresources, Biotechnology, Ethnopharmacology and Health, Faculty of Sciences, Mohammed First University, BP 717, Oujda 60000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3673-7904","authenticated-orcid":false,"given":"Belkheir","family":"Hammouti","sequence":"additional","affiliation":[{"name":"Euromed Research Center, Euromed Polytechnic School, Euromed University of Fes (UEMF), Fes 30000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2027-3896","authenticated-orcid":false,"given":"Marie-Laure","family":"Fauconnier","sequence":"additional","affiliation":[{"name":"Laboratory of Chemistry of Natural Molecules, University of Li\u00e8ge, Gembloux Agro-Bio Tech. 2, Passage des D\u00e9port\u00e9s, B-5030 Gembloux, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6725-3334","authenticated-orcid":false,"given":"Alicia","family":"Ayerdi Gotor","sequence":"additional","affiliation":[{"name":"Institut Polytechnique UniLaSalle, AGHYLE, UP 2018.C101, UniLaSalle, 19 rue Pierre Waguet, BP 30313, 60026 Beauvais, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6489-3109","authenticated-orcid":false,"given":"Larbi","family":"Rhazi","sequence":"additional","affiliation":[{"name":"Institut Polytechnique UniLaSalle, Universit\u00e9 d\u2019Artois, ULR 7519, 19 Rue Pierre Waguet, BP 30313, 60026 Beauvais, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1932-8850","authenticated-orcid":false,"given":"Mohammed","family":"Ramdani","sequence":"additional","affiliation":[{"name":"Laboratory of Applied and Environmental Chemistry (LCAE), Faculty of Sciences, Mohammed First University, B.P. 717, Oujda 60000, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,6,21]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.geomorph.2006.07.043","article-title":"Impacts of Sea-Level Rise on the Moroccan Coastal Zone: Quantifying Coastal Erosion and Flooding in the Tangier Bay","volume":"107","author":"Snoussi","year":"2009","journal-title":"Geomorphology"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1515\/BOT.2001.023","article-title":"A CheckList of Marine Seaweeds of the Mediterranean and Atlantic Coasts of Morocco. 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