{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T03:01:41Z","timestamp":1788318101965,"version":"build-2803163510"},"reference-count":185,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T00:00:00Z","timestamp":1752019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China","award":["82170406"],"award-info":[{"award-number":["82170406"]}]},{"name":"National Natural Science Foundation of China","award":["81970238"],"award-info":[{"award-number":["81970238"]}]},{"name":"National Natural Science Foundation of China","award":["IEC\\NSFC\\201094"],"award-info":[{"award-number":["IEC\\NSFC\\201094"]}]},{"name":"The Royal Society UK","award":["82170406"],"award-info":[{"award-number":["82170406"]}]},{"name":"The Royal Society UK","award":["81970238"],"award-info":[{"award-number":["81970238"]}]},{"name":"The Royal Society UK","award":["IEC\\NSFC\\201094"],"award-info":[{"award-number":["IEC\\NSFC\\201094"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Marine-derived compounds represent a rich source of structurally diverse molecules with therapeutic potential for cancer, renal disorders, metabolic-associated fatty liver disease (MAFLD), and atherosclerosis. This review systematically evaluates recent advances, highlighting compounds such as Microcolin H, Benzosceptrin C, S14, HN-001, Equisetin, glycosides (e.g., cucumarioside A2-2), ilimaquinone, and Aplidin (plitidepsin). Key mechanisms include autophagy modulation, immune checkpoint inhibition, anti-inflammatory effects, and mitochondrial homeostasis. Novel findings reveal glycosides\u2019 dual role in cytotoxicity and immunomodulation, ilimaquinone\u2019s induction of the DNA damage response, and Aplidin\u2019s disruption of protein synthesis via eEF1A2 binding. Pharmacokinetic challenges and structure\u2013activity relationships are critically analyzed, emphasizing nanodelivery systems and synthetic analog development. This review bridges mechanistic insights with translational potential, offering a cohesive framework for future drug development.<\/jats:p>","DOI":"10.3390\/md23070283","type":"journal-article","created":{"date-parts":[[2025,7,10]],"date-time":"2025-07-10T09:38:27Z","timestamp":1752140307000},"page":"283","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Marine-Derived Compounds: A New Horizon in Cancer, Renal, and Metabolic Disease Therapeutics"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8683-509X","authenticated-orcid":false,"given":"Jinwei","family":"Zhang","sequence":"first","affiliation":[{"name":"Institute of Biomedical and Clinical Sciences, Medical School, Faculty of Health and Life Sciences, Hatherly Laboratories, Streatham Campus, University of Exeter, Exeter EX4 4PS, UK"},{"name":"State Key Laboratory of Chemical Biology, Research Center of Chemical Kinomics, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. 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