{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:55:05Z","timestamp":1787028905797,"version":"build-2736575974"},"reference-count":115,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T00:00:00Z","timestamp":1753315200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Xinjiang Uygur Autonomous Region Tianchi Talent Introduction Program-Young Doctor","award":["5105240151f"],"award-info":[{"award-number":["5105240151f"]}]},{"name":"Xinjiang Uygur Autonomous Region Tianchi Talent Introduction Program-Young Doctor","award":["51052300410"],"award-info":[{"award-number":["51052300410"]}]},{"name":"Tianchi Innovation Leading Talent Project","award":["5105240151f"],"award-info":[{"award-number":["5105240151f"]}]},{"name":"Tianchi Innovation Leading Talent Project","award":["51052300410"],"award-info":[{"award-number":["51052300410"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Microorganisms serve as a vital source of natural anticancer agents, with many of their secondary metabolites already employed in clinical oncology. In recent years, salt-adapted microbes, including halophilic and halotolerant species from marine, salt lake, and other high-salinity environments, have gained significant attention. Their unique adaptation mechanisms and diverse secondary metabolites offer promising potential for novel anticancer drug discovery. This review consolidated two decades of research alongside current global cancer statistics to evaluate the therapeutic potential of salt-adapted microorganisms. Halophilic and halotolerant species demonstrate significant promise, with their bioactive metabolites exhibiting potent inhibitory effects against major cancer cell lines, particularly in lung and breast cancer. Evidence reveals structurally unique secondary metabolites displaying enhanced cytotoxicity compared to conventional anticancer drugs. Collectively, salt-adapted microorganisms represent an underexplored yet high-value resource for novel anticancer agents, offering potential solutions to chemotherapy resistance and treatment-related toxicity.<\/jats:p>","DOI":"10.3390\/md23080296","type":"journal-article","created":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T07:54:26Z","timestamp":1753343666000},"page":"296","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Salt-Adapted Microorganisms: A Promising Resource for Novel Anti-Cancer Drug Discovery"],"prefix":"10.3390","volume":"23","author":[{"given":"Longteng","family":"Fang","sequence":"first","affiliation":[{"name":"School of Pharmaceutical Sciences and Institute of Materia Medica, Xinjiang University, Urumqi 830017, China"},{"name":"School of Life Science and Technology, Xinjiang University, Urumqi 830017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences and Institute of Materia Medica, Xinjiang University, Urumqi 830017, China"},{"name":"School of Life Science and Technology, Xinjiang University, Urumqi 830017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marhaba","family":"Kader","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences and Institute of Materia Medica, Xinjiang University, Urumqi 830017, China"},{"name":"School of Life Science and Technology, Xinjiang University, Urumqi 830017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Ding","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences and Institute of Materia Medica, Xinjiang University, Urumqi 830017, China"},{"name":"School of Life Science and Technology, Xinjiang University, Urumqi 830017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8602-2360","authenticated-orcid":false,"given":"Shiyang","family":"Lu","sequence":"additional","affiliation":[{"name":"Analysis and Testing Center, Shenyang University of Chemical Technology, Shenyang 110142, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4855-0576","authenticated-orcid":false,"given":"Dong","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences and Institute of Materia Medica, Xinjiang University, Urumqi 830017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4561-9750","authenticated-orcid":false,"given":"Amit Raj","family":"Sharma","sequence":"additional","affiliation":[{"name":"Arkansas Biosciences Institute, Arkansas State University, Jonesboro, AR 72401, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwei","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences and Institute of Materia Medica, Xinjiang University, Urumqi 830017, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,24]]},"reference":[{"key":"ref_1","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA A Cancer J. 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