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This systematic review of 119 studies (2020\u20132024) identifies 512 novel terpenoids, accounting for 87% of the total discoveries to 2020, from five major classes (monoterpenes, sesquiterpenes, diterpenes, sesterterpenes, and triterpenes) isolated from 104 fungal strains across 33 genera. Sesquiterpenoids and diterpenoids constitute the predominant chemical classes, with Trichoderma, Aspergillus, Eutypella, and Penicillium being the most productive genera. These fungi were primarily sourced from distinct marine niches, including deep sea sediments, algal associations, mangrove ecosystems, and invertebrate symbioses. Notably, 57% of the 266 tested compounds exhibited diverse biological activities, encompassing anti-inflammatory, antibacterial, antimicroalgal, antifungal, cytotoxic effects, etc. The chemical diversity and biological activities of these marine fungal terpenoids underscore their value as promising lead compounds for pharmaceutical development.<\/jats:p>","DOI":"10.3390\/md23080300","type":"journal-article","created":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T08:51:33Z","timestamp":1753692693000},"page":"300","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Structural Diversity and Bioactivities of Marine Fungal Terpenoids (2020\u20132024)"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3036-3879","authenticated-orcid":false,"given":"Minghua","family":"Jiang","sequence":"first","affiliation":[{"name":"Key Laboratory of Natural Microbial Medicine Research of Jiangxi Province, College of Life Sciences, Jiangxi Science and Technology Normal University, Nanchang 330013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senhua","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Marine Sciences, Sun Yat-Sen University, Zhuhai 519082, China"},{"name":"State Key Laboratory of Environmental Adaptability for Industrial Products, Zhuhai 519082, China"},{"name":"Southern Marine Sciences and Engineering Guangdong Laboratory (Zhuhai), Zhuhai 519082, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9814-6686","authenticated-orcid":false,"given":"Zhibin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Biodiversity Conservation and Bioresource Utilization, College of Life Sciences, Jiangxi Normal University, Nanchang 330022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Xiao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Microbial Medicine Research of Jiangxi Province, College of Life Sciences, Jiangxi Science and Technology Normal University, Nanchang 330013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3184-2844","authenticated-orcid":false,"given":"Du","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Microbial Medicine Research of Jiangxi Province, College of Life Sciences, Jiangxi Science and Technology Normal University, Nanchang 330013, China"},{"name":"Jiangxi Province Key Laboratory of Biodiversity Conservation and Bioresource Utilization, College of Life Sciences, Jiangxi Normal University, Nanchang 330022, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2765-4015","authenticated-orcid":false,"given":"Lan","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Marine Sciences, Sun Yat-Sen University, Zhuhai 519082, China"},{"name":"State Key Laboratory of Environmental Adaptability for Industrial Products, Zhuhai 519082, China"},{"name":"Southern Marine Sciences and Engineering Guangdong Laboratory (Zhuhai), Zhuhai 519082, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,7,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Imhoff, J.F. 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