{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T02:07:50Z","timestamp":1787796470129,"version":"build-2784847793"},"reference-count":84,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Mangroves represent a promising yet underexplored source of natural products. Sonneratia caseolaris (mangrove apple) is a widely distributed species with a long history of use in traditional medicine, and it is receiving increasing recognition for its bioactive secondary metabolites. Research has expanded in recent decades, but findings remain dispersed across diverse sources, complicating interpretation of its chemistry and pharmacological potential. This review consolidates four decades of investigations, documenting 141 identified compounds from studies largely restricted to India, Bangladesh, Indonesia, and China and focusing on leaves, fruits, bark, stems, and twigs, with roots notably unexplored. The phytochemical profile is dominated by phenolic acids, flavonoids, and tannins, alongside terpenoids, steroids, fatty acids, fatty alcohols, aldehydes, hydrocarbons, and polysaccharides. The most extensively studied activities are antioxidant and antimicrobial, with extracts consistently exhibiting strong free-radical scavenging capacity and broad-spectrum antibacterial and antifungal effects, including efficacy against drug-resistant strains. Additional reports describe central nervous system depressant, antidiarrheal, metabolic, anti-inflammatory, analgesic, antipyretic, and anti-allergic activities. In contrast, anticancer investigations remain scarce, despite promising outcomes reported for related mangrove taxa. By consolidating and critically evaluating the existing evidence, this review highlights the pharmacological potential of S. caseolaris and identifies key knowledge gaps to guide future marine drug discovery.<\/jats:p>","DOI":"10.3390\/md23100378","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T11:28:32Z","timestamp":1758886112000},"page":"378","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Phytochemistry and Pharmacological Potential of the Mangrove Plant Sonneratia caseolaris: A Comprehensive Review"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9461-0595","authenticated-orcid":false,"given":"Federico","family":"Cerri","sequence":"first","affiliation":[{"name":"Department of Earth and Environmental Sciences DISAT, University of Milano-Bicocca, Piazza della Scienza 1, 20126 Milan, Italy"},{"name":"MaRHE Centre (Marine Research and Higher Education Center), Magoodhoo Island, Faafu Atoll 12030, Maldives"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6065-8192","authenticated-orcid":false,"given":"Paolo","family":"Galli","sequence":"additional","affiliation":[{"name":"Department of Earth and Environmental Sciences DISAT, University of Milano-Bicocca, Piazza della Scienza 1, 20126 Milan, Italy"},{"name":"MaRHE Centre (Marine Research and Higher Education Center), Magoodhoo Island, Faafu Atoll 12030, Maldives"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,9,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/0045-6535(93)90070-L","article-title":"Mangroves-a Carbon Source and Sink","volume":"27","author":"Eong","year":"1993","journal-title":"Chemosphere"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"R443","DOI":"10.1016\/j.cub.2005.06.008","article-title":"How Effective Were Mangroves as a Defence against the Recent Tsunami?","volume":"15","author":"Jayatissa","year":"2005","journal-title":"Curr. 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