{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:22:32Z","timestamp":1787314952872,"version":"build-2736575974"},"reference-count":19,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T00:00:00Z","timestamp":1761782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ningbo Key Science and Technology Development Program","award":["2021Z046"],"award-info":[{"award-number":["2021Z046"]}]},{"DOI":"10.13039\/501100013314","name":"National 111 Project of China","doi-asserted-by":"publisher","award":["D16013"],"award-info":[{"award-number":["D16013"]}],"id":[{"id":"10.13039\/501100013314","id-type":"DOI","asserted-by":"publisher"}]},{"name":"High-Level Talents Special Program of Zhejiang","award":["2022R52036"],"award-info":[{"award-number":["2022R52036"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>This research explored the chemical composition of the soft coral Sarcophyton sp., leading to the discovery of six previously unreported cembranoids, sarcophynoids D\u2013I (1\u20136), and three known analog compounds (7\u20139). Structural elucidation of the new metabolites was achieved by spectroscopic methods, including one- and two-dimensional (1D and 2D) NMR (COSY, HSQC and HMBC), high-resolution electrospray ionization mass spectrometry (HRESIMS), quantum mechanical NMR (QM-NMR) methods, electronic circular dichroism (ECD) calculations, and comparison with literature data. All isolated substances were screened for antibacterial activities, and most exhibited moderate inhibitory effects against six pathogenic bacterial strains, with MIC values between 8 and 64 \u03bcg\/mL. In addition, the effects of these compounds on LPS and IFN-\u03b3 stimulated RAW264.7 cells, focused on the release of NO and TNF-\u03b1, were also evaluated, but were inactive at 20 \u03bcM.<\/jats:p>","DOI":"10.3390\/md23110422","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T03:33:07Z","timestamp":1761881587000},"page":"422","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cembrane-Based Diterpenoids Isolated from the Soft Coral Sarcophyton sp."],"prefix":"10.3390","volume":"23","author":[{"given":"Yueping","family":"Wang","sequence":"first","affiliation":[{"name":"Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Ningbo University, Ningbo 315211, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohui","family":"Li","sequence":"additional","affiliation":[{"name":"Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Ningbo University, Ningbo 315211, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusen","family":"Guo","sequence":"additional","affiliation":[{"name":"Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Ningbo University, Ningbo 315211, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Te","family":"Li","sequence":"additional","affiliation":[{"name":"Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Ningbo University, Ningbo 315211, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Yan","sequence":"additional","affiliation":[{"name":"Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Ningbo University, Ningbo 315211, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Ouyang","sequence":"additional","affiliation":[{"name":"Institute of Drug Discovery Technology, Ningbo University, Ningbo 315211, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4978-4083","authenticated-orcid":false,"given":"Wenhan","family":"Lin","sequence":"additional","affiliation":[{"name":"Ningbo Institute of Marine Medicine, Peking University, Ningbo 315800, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Wu","sequence":"additional","affiliation":[{"name":"Ocean College, Zhejiang University, Hangzhou 310058, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0035-4346","authenticated-orcid":false,"given":"Hongyu","family":"Hu","sequence":"additional","affiliation":[{"name":"Xingzhi College, Zhejiang Normal University, Lanxi 321004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0196-7278","authenticated-orcid":false,"given":"Shan","family":"He","sequence":"additional","affiliation":[{"name":"Li Dak Sum Yip Yio Chin Kenneth Li Marine Biopharmaceutical Research Center, Ningbo University, Ningbo 315211, China"},{"name":"Ningbo Institute of Marine Medicine, Peking University, Ningbo 315800, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,10,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Wang, C., Zhang, J., Li, K., Yang, J., Li, L., Wang, S., Hou, H., and Li, P. 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Molecules, 24.","DOI":"10.3390\/molecules24040781"},{"key":"ref_5","first-page":"1301","article-title":"The bioactive natural products and biological activities of the red sea soft coral Sarcophyton: A review","volume":"6","author":"Hussien","year":"2015","journal-title":"Res. J. Pharm. Biol. Chem. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Elkhawas, Y.A., Elissawy, A.M., Elnaggar, M.S., Mostafa, N.M., Al-Sayed, E., Bishr, M.M., Singab, A.N.B., and Salama, O.M. (2020). Chemical diversity in species belonging to soft coral genus Sarcophyton and its impact on biological activity: A review. Mar. Drugs, 18.","DOI":"10.3390\/md18010041"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1080\/14786419.2021.1948041","article-title":"Four new cembranoids from the South China Sea soft coral Sarcophyton trocheliophorum","volume":"37","author":"Ren","year":"2023","journal-title":"Nat. Prod. 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Biot."}],"container-title":["Marine Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-3397\/23\/11\/422\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T03:37:19Z","timestamp":1761881839000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-3397\/23\/11\/422"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,30]]},"references-count":19,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["md23110422"],"URL":"https:\/\/doi.org\/10.3390\/md23110422","relation":{},"ISSN":["1660-3397"],"issn-type":[{"value":"1660-3397","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,30]]}}}