{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:04:16Z","timestamp":1770743056300,"version":"3.49.0"},"reference-count":56,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T00:00:00Z","timestamp":1763510400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science and Technology Council, Taiwan","award":["NSTC 112-2221-E-002-040-MY3"],"award-info":[{"award-number":["NSTC 112-2221-E-002-040-MY3"]}]},{"name":"National Science and Technology Council, Taiwan","award":["NSTC 112-2320-B-002-013-MY3"],"award-info":[{"award-number":["NSTC 112-2320-B-002-013-MY3"]}]},{"name":"National Science and Technology Council, Taiwan","award":["NSTC 113-2321-B-002-037"],"award-info":[{"award-number":["NSTC 113-2321-B-002-037"]}]},{"name":"National Science and Technology Council, Taiwan","award":["NSTC114-2221-E-038-004"],"award-info":[{"award-number":["NSTC114-2221-E-038-004"]}]},{"name":"Fisheries Research Institute, Ministry of Agriculture, Taiwan","award":["111AS-6.3.1-A1"],"award-info":[{"award-number":["111AS-6.3.1-A1"]}]},{"name":"Fisheries Research Institute, Ministry of Agriculture, Taiwan","award":["112AS-6.3.1-A1"],"award-info":[{"award-number":["112AS-6.3.1-A1"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Wound healing is a complex process involving coordinated actions of multiple cell types. Therefore, when developing therapeutics to promote wound healing, it is essential to consider the synergistic contributions of various cells at different stages of the healing process. In this study, we evaluated the potential of different extracts of Botryocladia leptopoda as wound-healing agents by examining their effects on antioxidant activity, cytotoxicity, cell migration, anti-inflammatory properties, and expressions of specific biomarkers associated with wound healing. Results indicated that the ethanol extract (FE) and hexane extract (HE) exhibited the highest DPPH radical scavenging activity, reaching up to 94%. The alkaline extract (AE) showed the strongest antioxidant ability in the FICA assay, with a maximum of 99%. In addition, the FE and AE provided anti-inflammatory actions that inhibited tumor necrosis factor (TNF)-\u03b1 and interleukin (IL)-6 in lipopolysaccharide (LPS)-treated RAW 264.7 cells. Further analyses suggested that the FE and AE enhanced cell proliferation (210% and 112%) and migration (442.2% and 535.6%) and regulated wound healing-related genes, including matrix metalloproteinase 2, MMP9, and tissue inhibitor of metalloproteinase 2 (TIMP2) to avoid scar formation and accelerate wound healing. Lastly, the identification of potential compounds within the extract using the UHPLC system further supports its prospective medical applications. Taken together, these findings indicated that the FE and AE from B. leptopoda exhibited remarkable in vitro wound-healing properties, highlighting their potential for applications in pharmaceutical industries and health food development.<\/jats:p>","DOI":"10.3390\/md23110444","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T11:17:27Z","timestamp":1763551047000},"page":"444","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Botryocladia leptopoda Extracts Promote Wound Healing Ability via Antioxidant and Anti-Inflammatory Activities and Regulation of MMP\/TIMP Expression"],"prefix":"10.3390","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3018-1864","authenticated-orcid":false,"given":"Shin-Ping","family":"Lin","sequence":"first","affiliation":[{"name":"School of Food Safety, Taipei Medical University, Taipei 11031, Taiwan"},{"name":"Ph.D. Program in Drug Discovery and Development Industry, Taipei Medical University, Taipei 11031, Taiwan"},{"name":"Research Center of Biomedical Device, Taipei Medical University, Taipei 11031, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-8199-593X","authenticated-orcid":false,"given":"Tsung-Kai","family":"Yi","sequence":"additional","affiliation":[{"name":"Seafood Technology Division, Fisheries Research Institute, Ministry of Agriculture, Keelung 20246, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Feng","family":"Kao","sequence":"additional","affiliation":[{"name":"Seafood Technology Division, Fisheries Research Institute, Ministry of Agriculture, Keelung 20246, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Chieh","family":"Tu","sequence":"additional","affiliation":[{"name":"Seafood Technology Division, Fisheries Research Institute, Ministry of Agriculture, Keelung 20246, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen-Che","family":"Hsieh","sequence":"additional","affiliation":[{"name":"Department of Seafood Science, College of Hydrosphere, National Kaohsiung University of Science and Technology, Kaohsiung 81157, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-7634-2189","authenticated-orcid":false,"given":"Yu-Chieh","family":"Chou","sequence":"additional","affiliation":[{"name":"Ph.D. Program in Drug Discovery and Development Industry, Taipei Medical University, Taipei 11031, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jheng-Jhe","family":"Lu","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology, National Taiwan University, Taipei 10617, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shella Permatasari","family":"Santoso","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering, Faculty of Engineering, Widya Mandala Surabaya Catholic University, Surabaya 60114, Indonesia"},{"name":"Chemical Engineering Master Program, Widya Mandala Surabaya Catholic University, Surabaya 60114, Indonesia"},{"name":"Collaborative Research Center for Zero Waste and Sustainability, Widya Mandala Surabaya Catholic University, Surabaya 60114, Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huey-Jine","family":"Chai","sequence":"additional","affiliation":[{"name":"Seafood Technology Division, Fisheries Research Institute, Ministry of Agriculture, Keelung 20246, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0387-7804","authenticated-orcid":false,"given":"Kuan-Chen","family":"Cheng","sequence":"additional","affiliation":[{"name":"Institute of Biotechnology, National Taiwan University, Taipei 10617, Taiwan"},{"name":"Institute of Food Science and Technology, National Taiwan University, Taipei 10617, Taiwan"},{"name":"Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan"},{"name":"Department of Optometry, Asia University, Taichung 41354, Taiwan"},{"name":"Department of Food Science, Fu Jen Catholic University, New Taipei City 242062, Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Gouripriya, D., Adhikari, J., Debnath, P., Ghosh, S., Ghosh, P., Thomas, S., Ghandilyan, E., Gorbatov, P., Kuchukyan, E., and Gasparyan, S. (2024). 3D printing of bacterial cellulose for potential wound healing applications: Current trends and prospects. Int. J. Biol. Macromol., 279.","DOI":"10.1016\/j.ijbiomac.2024.135213"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1590\/abd1806-4841.20164741","article-title":"Wound healing-A literature review","volume":"91","author":"Gonzalez","year":"2016","journal-title":"An. Bras. Dermatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.jaad.2015.08.070","article-title":"Wound healing and treating wounds: Chronic wound care and management","volume":"74","author":"Powers","year":"2016","journal-title":"J. Am. Acad. Dermatol."},{"key":"ref_4","first-page":"17","article-title":"The negative impact of medications on wound healing","volume":"32","author":"Bennett","year":"2024","journal-title":"Wound Pract. Res."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Menaa, F., Wijesinghe, U., Thiripuranathar, G., Althobaiti, N.A., Albalawi, A.E., Khan, B.A., and Menaa, B. (2021). Marine algae-derived bioactive compounds: A new wave of nanodrugs?. Mar. Drugs, 19.","DOI":"10.3390\/md19090484"},{"key":"ref_6","first-page":"187","article-title":"Exploration of Bioactive Functional Molecules from Marine Algae: Challenges and Applications in Nutraceuticals","volume":"2024","author":"Chandrasekhar","year":"2024","journal-title":"Mar. Bioact. Mol. Biomed. Pharmacother. Appl."},{"key":"ref_7","doi-asserted-by":"crossref","unstructured":"Pruteanu, L.L., Bailey, D.S., Gr\u0103dinaru, A.C., and J\u00e4ntschi, L. (2023). The biochemistry and effectiveness of antioxidants in food, fruits, and marine algae. Antioxidants, 12.","DOI":"10.3390\/antiox12040860"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Imchen, T., and Singh, K.S. (2023). Marine algae colorants: Antioxidant, anti-diabetic properties and applications in food industry. Algal Res., 69.","DOI":"10.1016\/j.algal.2022.102898"},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Pradhan, B., and Ki, J.-S. (2023). Biological activity of algal derived carrageenan: A comprehensive review in light of human health and disease. Int. J. Biol. Macromol., 238.","DOI":"10.1016\/j.ijbiomac.2023.124085"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Leong, Y.K., and Chang, J.-S. (2024). Proteins and bioactive peptides from algae: Insights into antioxidant, anti-hypertensive, anti-diabetic and anti-cancer activities. Trends Food Sci. Technol., 145.","DOI":"10.1016\/j.tifs.2024.104352"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Fernandes, F., Martins, R., Barbosa, M., and Valent\u00e3o, P. (2024). Algae-based supplements claiming weight loss properties: Authenticity control and scientific-based evidence on their effectiveness. Mar. Drugs, 22.","DOI":"10.3390\/md22030123"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Yurika, N., Montuori, E., and Lauritano, C. (2024). Marine microalgal products with activities against age-related cardiovascular diseases. Mar. Drugs, 22.","DOI":"10.3390\/md22050229"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Minhas, L.A., Kaleem, M., Farooqi, H.M.U., Kausar, F., Waqar, R., Bhatti, T., Aziz, S., Jung, D.W., and Mumtaz, A.S. (2024). Algae-derived bioactive compounds as potential nutraceuticals for cancer therapy: A comprehensive review. Algal Res., 78.","DOI":"10.1016\/j.algal.2024.103396"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Ch\u00e9nais, B. (2021). Algae and microalgae and their bioactive molecules for human health. Molecules, 26.","DOI":"10.3390\/molecules26041185"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.2174\/138920112804724828","article-title":"The potential of microalgae for the production of bioactive molecules of pharmaceutical interest","volume":"13","author":"Mimouni","year":"2012","journal-title":"Curr. Pharm. Biotechnol."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Kuznetsova, T.A., Andryukov, B.G., Besednova, N.N., Zaporozhets, T.S., and Kalinin, A.V. (2020). Marine algae polysaccharides as basis for wound dressings, drug delivery, and tissue engineering: A review. J. Mar. Sci. Eng., 8.","DOI":"10.3390\/jmse8070481"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Kumar, M., Kumar, D., Garg, Y., Mahmood, S., Chopra, S., and Bhatia, A. (2023). Marine-derived polysaccharides and their therapeutic potential in wound healing application\u2014A review. Int. J. Biol. Macromol., 253.","DOI":"10.1016\/j.ijbiomac.2023.127331"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ijbiomac.2015.02.050","article-title":"Marine-derived biological macromolecule-based biomaterials for wound healing and skin tissue regeneration","volume":"77","author":"Chandika","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_19","first-page":"251","article-title":"Application of algae in wound healing","volume":"2","author":"Ajayi","year":"2023","journal-title":"Next-Gener. Algae"},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Ma, J., Fang, Y., Yu, H., Yi, J., Ma, Y., Lei, P., Yang, Q., Jin, L., Wu, W., and Li, H. (2024). Recent advances in living algae seeding wound dressing: Focusing on diabetic chronic wound healing. Adv. Funct. Mater., 34.","DOI":"10.1002\/adfm.202308387"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"16","DOI":"10.13005\/ojc\/380102","article-title":"Secondary metabolites screening, in vitro antioxidant and antidiabetic activity of marine red alga Botryocladia leptopoda (J. Agardh) Kylin","volume":"38","author":"Suthan","year":"2022","journal-title":"Orient. J. Chem."},{"key":"ref_22","doi-asserted-by":"crossref","unstructured":"Hsieh, C.-C., Yi, T.-K., Kao, Y.-F., Lin, S.-P., Tu, M.-C., Chou, Y.-C., Lu, J.-J., Chai, H.-J., and Cheng, K.-C. (2024). Comparative efficacy of Botryocladia leptopoda extracts in scar Inhibition and skin regeneration: A study on UV protection, collagen synthesis, and fibroblast proliferation. Molecules, 29.","DOI":"10.3390\/molecules29235688"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Mssillou, I., Bakour, M., Slighoua, M., Laaroussi, H., Saghrouchni, H., Amrati, F.E.-Z., Lyoussi, B., and Derwich, E. (2022). Investigation on wound healing effect of Mediterranean medicinal plants and some related phenolic compounds: A review. J. Ethnopharmacol., 298.","DOI":"10.1016\/j.jep.2022.115663"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jss.2019.09.011","article-title":"Quercetin promotes diabetic wound healing via switching macrophages from M1 to M2 polarization","volume":"246","author":"Fu","year":"2020","journal-title":"J. Surg. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"4230","DOI":"10.1039\/C9BM00991D","article-title":"Polydopamine\/puerarin nanoparticle-incorporated hybrid hydrogels for enhanced wound healing","volume":"7","author":"Zhang","year":"2019","journal-title":"Biomater. Sci."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s12221-018-7528-6","article-title":"Naringin-loaded poly (\u03b5-caprolactone)\/gelatin electrospun mat as a potential wound dressing: In vitro and in vivo evaluation","volume":"19","author":"Salehi","year":"2018","journal-title":"Fibers Polym."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1039\/C7RA10334D","article-title":"Morin incorporated polysaccharide\u2013protein (psyllium\u2013keratin) hydrogel scaffolds accelerate diabetic wound healing in Wistar rats","volume":"8","author":"Ponrasu","year":"2018","journal-title":"RSC Adv."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.fsi.2020.02.071","article-title":"Isoliquiritin promote angiogenesis by recruiting macrophages to improve the healing of zebrafish wounds","volume":"100","author":"Liu","year":"2020","journal-title":"Fish Shellfish Immunol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/j.ijbiomac.2018.02.066","article-title":"Impact of acidic, water and alkaline extraction on structural features, antioxidant activities of Laminaria japonica polysaccharides","volume":"112","author":"Sun","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"23759","DOI":"10.1021\/acs.jafc.5c07001","article-title":"From Terrestrial Plants to Marine Macroalgae: A Comprehensive Review of Cell Wall Component-Properties, Extraction, Modification, and Application of Algal Cellulose","volume":"73","author":"Li","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.ijbiomac.2015.09.030","article-title":"Characteristics and antioxidant of Ulva intestinalis sulphated polysaccharides extracted with different solvents","volume":"81","author":"Peasura","year":"2015","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1007\/s00210-024-03538-1","article-title":"Polyphenols in wound healing: Unlocking prospects with clinical applications","volume":"398","author":"Utpal","year":"2025","journal-title":"Naunyn-Schmiedeberg\u2019s Arch. Pharmacol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.1007\/s10811-021-02446-8","article-title":"Antioxidant activity and related chemical composition of extracts from Brazilian beach-cast marine algae: Opportunities of turning a waste into a resource","volume":"33","author":"Harb","year":"2021","journal-title":"J. Appl. Phycol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Joorabloo, A., and Liu, T. (2024). Recent advances in reactive oxygen species scavenging nanomaterials for wound healing. Exploration, 4.","DOI":"10.1002\/EXP.20230066"},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Li, J., Shen, Y., Wang, X., Wu, T., Huang, Q., Shen, M., Xu, S., and Li, Y. (2024). A multilayer hydrogel incorporating urolithin B promotes diabetic wound healing via ROS scavenging and angiogenesis. Chem. Eng. J., 496.","DOI":"10.1016\/j.cej.2024.153661"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.lwt.2007.06.013","article-title":"Antioxidant activity of three edible seaweeds from two areas in South East Asia","volume":"41","author":"Chew","year":"2008","journal-title":"LWT-Food Sci. Technol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.foodchem.2009.02.041","article-title":"Total phenolic compounds, radical scavenging and metal chelation of extracts from Icelandic seaweeds","volume":"116","author":"Wang","year":"2009","journal-title":"Food Chem."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Secor, P.R., James, G.A., Fleckman, P., Olerud, J.E., McInnerney, K., and Stewart, P.S. (2011). Staphylococcus aureus Biofilm and Planktonic cultures differentially impact gene expression, mapk phosphorylation, and cytokine production in human keratinocytes. BMC Microbiol., 11.","DOI":"10.1186\/1471-2180-11-143"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/etp.12008","article-title":"Granulation tissue formation and remodeling","volume":"24","author":"Larjava","year":"2011","journal-title":"Endod. Top."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1152\/physrev.2003.83.3.835","article-title":"Regulation of wound healing by growth factors and cytokines","volume":"83","author":"Werner","year":"2003","journal-title":"Physiol. Rev."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"4927","DOI":"10.1007\/s10570-017-1448-x","article-title":"Novel dextran modified bacterial cellulose hydrogel accelerating cutaneous wound healing","volume":"24","author":"Lin","year":"2017","journal-title":"Cellulose"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"11044","DOI":"10.1158\/0008-5472.CAN-05-2617","article-title":"Therapeutic efficacy of endostatin exhibits a biphasic dose-response curve","volume":"65","author":"Celik","year":"2005","journal-title":"Cancer Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1089\/wound.2014.0581","article-title":"Metalloproteinases and wound healing","volume":"4","author":"Caley","year":"2015","journal-title":"Adv. Wound Care"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.1074\/jbc.M107611200","article-title":"Matrix metalloproteinase gelatinase B (MMP-9) coordinates and effects epithelial regeneration","volume":"277","author":"Mohan","year":"2002","journal-title":"J. Biol. Chem."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/cbf.1537","article-title":"Matrix metalloproteinase-2 and -9 activities in human keloids, hypertrophic and atrophic scars: A pilot study","volume":"27","author":"Menderes","year":"2009","journal-title":"Cell Biochem. Funct."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/biof.5520330204","article-title":"Matrine inhibits PMA-induced MMP-1 expression in human dermal fibroblasts","volume":"33","author":"Jung","year":"2008","journal-title":"Biofactors"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jep.2016.12.019","article-title":"Davallia bilabiata exhibits anti-angiogenic effect with modified MMP-2\/TIMP-2 secretion and inhibited VEGF ligand\/receptors expression in vascular endothelial cells","volume":"196","author":"Liu","year":"2017","journal-title":"J. Ethnopharmacol."},{"key":"ref_48","doi-asserted-by":"crossref","unstructured":"Pei, J., Kanwal, S., Sivaramakrishnan, R., and Katelakha, K. (2025). Therapeutic potential of microalgae-derived natural compounds in diabetic wound healing: A comprehensive review. Heliyon, 11.","DOI":"10.1016\/j.heliyon.2025.e42723"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Gager, L., Lalegerie, F., Connan, S., and Stiger-Pouvreau, V. (2021). Marine algal derived phenolic compounds and their biological activities for medicinal and cosmetic applications. Recent Advances in Micro and Macroalgal Processing: Food and Health Perspectives, John Wiley & Sons, Inc.","DOI":"10.1002\/9781119542650.ch11"},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Fern\u00e1ndez, S., Arn\u00e1iz, V., Rufo, D., and Arroyo, Y. (2024). Current status of indole-derived marine natural products: Synthetic approaches and therapeutic applications. Mar. Drugs, 22.","DOI":"10.3390\/md22030126"},{"key":"ref_51","doi-asserted-by":"crossref","unstructured":"Vasilakis, G., Marka, S., Ntzouvaras, A., Zografaki, M.-E., Kyriakopoulou, E., Kalliampakou, K.I., Bekiaris, G., Korakidis, E., Papageorgiou, N., and Christofi, S. (2025). Wound healing, antioxidant, and antiviral properties of bioactive polysaccharides of microalgae strains isolated from Greek Coastal Lagoons. Mar. Drugs, 23.","DOI":"10.3390\/md23020077"},{"key":"ref_52","first-page":"365","article-title":"Recent studies of antioxidant quinoline derivatives","volume":"13","author":"Tekiner","year":"2013","journal-title":"Mini Rev. Med. Chem."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1007\/s42452-019-1339-x","article-title":"pH-sensitive biopolymeric hydrogel-based on indole-3-acetic acid for wound healing and anti-cancer applications","volume":"1","author":"Chitra","year":"2019","journal-title":"SN Appl. Sci."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"17543","DOI":"10.1021\/acs.jafc.3c04022","article-title":"The Chemistry Behind the Folin\u2013Ciocalteu method for the estimation of (Poly)phenol content in food: Total phenolic intake in a mediterranean dietary pattern","volume":"71","year":"2023","journal-title":"J. Agric. Food Chem."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1021\/jf00018a005","article-title":"Antioxidative properties of xanthan on the autoxidation of soybean oil in cyclodextrin emulsion","volume":"40","author":"Shimada","year":"1992","journal-title":"J. Agric. Food Chem."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1006\/abbi.1994.1485","article-title":"Action of phenolic derivatives (acetaminophen, salicylate, and 5-aminosalicylate) as inhibitors of membrane lipid peroxidation and as peroxyl radical scavengers","volume":"315","author":"Dinis","year":"1994","journal-title":"Arch. Biochem. Biophys."}],"container-title":["Marine Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-3397\/23\/11\/444\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T11:27:47Z","timestamp":1763551667000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-3397\/23\/11\/444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,19]]},"references-count":56,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["md23110444"],"URL":"https:\/\/doi.org\/10.3390\/md23110444","relation":{},"ISSN":["1660-3397"],"issn-type":[{"value":"1660-3397","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,19]]}}}