{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T19:12:00Z","timestamp":1792264320754,"version":"4.4.0"},"reference-count":152,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"MUR Progetto Eccellenza","award":["NA"],"award-info":[{"award-number":["NA"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Advances in neuroscience, immunology, and neuroimmunology have revealed that the nervous and immune systems form a bidirectional integrated network, ranging from regulating inflammation to directing stress responses, pivotal for the maintenance of the brain\u2013body physiology. Like peripheral inflammation, neuroinflammation is a conserved process aimed at activating innate\/adaptive immune and non-immune cells to effectively deal with bacteria, viruses, toxins, and injuries, and eventually at removing the microbial pathogens and supporting tissue repair and recovery. A failure of this process or the permanent release of pro-inflammatory mediators causes a condition called \u201cchronic low-grade neuroinflammation\u201d resulting in tissue damage and an increased risk of developing neurodegenerative diseases (NDD), such as Alzheimer\u2019s disease (AD), Parkinson\u2019s disease (PD), multiple sclerosis (MS), and amyotrophic lateral sclerosis (ALS). Marine-derived bioactive components are able to modulate lipid and glucose metabolism as well as inflammation and oxidative stress. In this review, we describe the neuroinflammatory process and its involvement in the pathogenesis and progression of AD, PD, MS, and ALS. Then, we discuss the potential therapeutic efficacy of select marine-derived bioactive components.<\/jats:p>","DOI":"10.3390\/md23110446","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T12:02:42Z","timestamp":1763640162000},"page":"446","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Marine Bioactive Components and Chronic Neuroinflammation: Focus on Neurodegenerative Disease"],"prefix":"10.3390","volume":"23","author":[{"given":"Elda","family":"Favari","sequence":"first","affiliation":[{"name":"Department of Food and Drug, University of Parma, Parco Area delle Scienze 27\/A, 43124 Parma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5699-0918","authenticated-orcid":false,"given":"Cinzia","family":"Parolini","sequence":"additional","affiliation":[{"name":"Department of Pharmacological and Biomolecular Sciences, Rodolfo Paoletti, Universit\u00e0 degli Studi di Milano, Via Balzaretti 9, 20133 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2025,11,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/ni.3666","article-title":"The movers and shapers in immune privilege of the CNS","volume":"18","author":"Engelhardt","year":"2017","journal-title":"Nat. Immunol."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Leunig, A., Gianeselli, M., Russo, S.J., and Swirski, F.K. (Nat. Rev. Immunol., 2025). Connection and communication between the nervous and immune systems, Nat. Rev. Immunol., online ahead of print.","DOI":"10.1038\/s41577-025-01199-6"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1098\/rspb.1953.0049","article-title":"Studies on the problem of corneal homografts","volume":"141","author":"Billingham","year":"1953","journal-title":"Proc. R. Soc. Lond. B Biol. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.it.2006.11.004","article-title":"What is immune privilege (not)?","volume":"28","author":"Galea","year":"2007","journal-title":"Trends Immunol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature14432","article-title":"Structural and functional features of central nervous system lymphatic vessels","volume":"523","author":"Louvea","year":"2015","journal-title":"Nature"},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Smyth, L.C.D., and Kipnis, J. (Nat. Rev. Immunol., 2025). Redefining CNS immune privilege, Nat. Rev. Immunol., online ahead of print.","DOI":"10.1038\/s41577-025-01175-0"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.cell.2010.02.016","article-title":"Mechanisms underlying inflammation in neurodegeneration","volume":"140","author":"Glass","year":"2010","journal-title":"Cell"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"118591","DOI":"10.1016\/j.lfs.2020.118591","article-title":"Marine n-3 polyunsaturated fatty acids: Efficacy on inflammatory-based disorders","volume":"263","author":"Parolini","year":"2020","journal-title":"Life Sci."},{"key":"ref_9","doi-asserted-by":"crossref","unstructured":"Yang, Q., Wang, G., and Zhang, F. (2020). Role of Peripheral Immune Cells-Mediated Inflammation on the Process of Neurodegenerative Diseases. Front. Immunol., 11.","DOI":"10.3389\/fimmu.2020.582825"},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Chiesa, G., Busnelli, M., Manzini, S., and Parolini, C. (2016). Nutraceuticals and Bioactive Components from Fish for Dyslipidemia and Cardiovascular Risk Reduction. Mar. Drugs, 14.","DOI":"10.3390\/md14060113"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Lamminp\u00e4\u00e4, I., Amedei, A., and Parolini, C. (2024). Effects of Marine-Derived Components on Cardiovascular Disease Risk Factors and Gut Microbiota Diversity. Mar. Drugs, 22.","DOI":"10.20944\/preprints202410.2395.v1"},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Parolini, C. (2023). The Role of Marine n-3 Polyunsaturated Fatty Acids in Inflammatory-Based Disease: The Case of Rheumatoid Arthritis. Mar. Drugs, 22.","DOI":"10.20944\/preprints202312.0180.v1"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Amedei, A., Lamminp\u00e4\u00e4, I., and Parolini, C. (2025). Potential and Future Therapeutic Applications of Eicosapentaenoic acid\/Docosahexaenoic Acid and Probiotics in Chronic Low-Grade Inflammation. Biomedicines, 13.","DOI":"10.3390\/biomedicines13102428"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Jensen, I.-J., and Maehre, H.K. (2016). Preclinical and Clinical Studies on Antioxidative, Antihypertensive and Cardioprotective Effect of Marine Proteins and Peptides-A Review. Mar. Drugs, 14.","DOI":"10.3390\/md14110211"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"T\u00f8rris, C., Sm\u00e5stuen, M.C., and Molin, M. (2018). Nutrients in Fish and Possible Associations with Cardiovascular Disease Risk Factors in Metabolic Syndrome. Nutrients, 10.","DOI":"10.3390\/nu10070952"},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Catanesi, M., Caioni, G., Castelli, V., Benedetti, E., d\u2019Angelo, M., and Cimini, A. (2021). Benefits under the Sea: The Role of Marine Compounds in Neurodegenerative Disorders. Mar. Drugs, 19.","DOI":"10.3390\/md19010024"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Hannan, M.A., Dash, R., Haque, M.N., Mohibbullah, M., Sohag, A.A.M., Rahman, M.A., Uddin, M.J., Alam, M., and Moon, I.S. (2020). Neuroprotective Potentials of Marine Algae and Their Bioactive Metabolites: Pharmacological Insights and Therapeutic Advances. Mar. Drugs, 18.","DOI":"10.20944\/preprints202005.0342.v1"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1161\/CIRCRESAHA.118.314669","article-title":"Inflammation and Its Role in Regeneration and Repair","volume":"124","author":"Cooke","year":"2019","journal-title":"Circ. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/glia.10154","article-title":"Microglia as neuroprotective, immunocompetent cells of the CNS","volume":"40","author":"Streit","year":"2002","journal-title":"Glia"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1096\/fj.201601222R","article-title":"Treating inflammation and infection in the 21st century: New hints from decoding resolution mediators and mechanisms","volume":"31","author":"Serhan","year":"2017","journal-title":"FASEB J."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.it.2019.01.007","article-title":"Mediators of the Resolution of the Inflammatory Response","volume":"40","author":"Sugimoto","year":"2019","journal-title":"Trends Immunol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1038\/s41591-019-0675-0","article-title":"Chronic inflammation in the etiology of disease across the life span","volume":"25","author":"Furman","year":"2019","journal-title":"Nat. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3522.e1","DOI":"10.1016\/j.cell.2023.07.015","article-title":"Snapshot: Choroid plexus brain barrier","volume":"186","author":"Gelb","year":"2023","journal-title":"Cell"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.tins.2021.07.002","article-title":"Macrophages on the margin: Choroid plexus immune responses","volume":"44","author":"Cui","year":"2021","journal-title":"Trends Neurosci."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"key":"ref_26","doi-asserted-by":"crossref","unstructured":"Parolini, C. (2025). Sepsis and high-density lipoproteins: Pathophysiology and potential new therapeutic targets. Biochim. Biophys. Acta Mol. Basis Dis., 1871.","DOI":"10.1016\/j.bbadis.2025.167761"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1056\/NEJMra1208623","article-title":"Severe sepsis and septic shock","volume":"369","author":"Angus","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"2450","DOI":"10.1016\/j.immuni.2021.10.012","article-title":"The immunology of sepsis","volume":"54","author":"Wiersinga","year":"2021","journal-title":"Immunity"},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Parolini, C. (2025). Pathophysiology of bone remodelling cycle: Role of immune system and lipids. Biochem. Pharmacol., 235.","DOI":"10.1016\/j.bcp.2025.116844"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/nrn1408","article-title":"HIF1 and oxygen sensing in the brain","volume":"5","author":"Sharp","year":"2004","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.vph.2015.08.006","article-title":"Beta2-adrenergic activity modulates vascular tone regulation in lecithin:cholesterol acyltransferase knockout mice","volume":"74","author":"Manzini","year":"2015","journal-title":"Vascul. Pharmacol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/mus.10191","article-title":"Inflammatory processes in amyotrophic lateral sclerosis","volume":"26","author":"McGeer","year":"2002","journal-title":"Muscle Nerve"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1002\/mds.21751","article-title":"Glial reactions in Parkinson\u2019s disease","volume":"23","author":"McGeer","year":"2008","journal-title":"Mov. Disord."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s00401-019-01980-7","article-title":"The contribution of astrocytes to the neuroinflammatory response in multiple sclerosis and experimental autoimmune encephalomyelitis","volume":"137","author":"Brambilla","year":"2019","journal-title":"Acta Neuropathol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12979-025-00529-5","article-title":"Systemic inflammation as a central player in the initiation and development of Alzheimer\u2019s disease","volume":"22","author":"Bayraktaroglu","year":"2025","journal-title":"Immun. Ageing"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.ncl.2007.03.009","article-title":"Genetics of Alzheimer\u2019s disease: A centennial review","volume":"25","year":"2007","journal-title":"Neurol. Clin."},{"key":"ref_37","doi-asserted-by":"crossref","unstructured":"Andrews, S.J., Renton, A.E., Fulton-Howard, B., and Podlesny-Drabiniok, A. (2023). Marcora E, Goate AM: The complex genetic architecture of Alzheimer\u2019s disease: Novel insights and future directions. EBioMedicine, 90.","DOI":"10.1016\/j.ebiom.2023.104511"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1086\/302553","article-title":"Early-onset autosomal dominant Alzheimer disease: Prevalence, genetic heterogeneity, and mutation spectrum","volume":"65","author":"Campion","year":"1999","journal-title":"Am. J. Hum. Genet."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s11910-020-01090-y","article-title":"Early-Onset Alzheimer\u2019s Disease: What is Missing in Research?","volume":"21","author":"Ayodele","year":"2021","journal-title":"Curr. Neurol. Nerosci. Rep."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Selkoe, D.J. (2011). Alzheimer\u2019s disease. Cold Spring Harb. Perspect. Biol., 3.","DOI":"10.1101\/cshperspect.a004457"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrm2101","article-title":"Soluble protein oligomers in neurodegeneration: Lessons from the Alzheimer\u2019s amyloid beta-peptide","volume":"8","author":"Haass","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer\u2019s disease: Progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"ref_43","doi-asserted-by":"crossref","unstructured":"Fedele, E. (2023). Anti-Amyloid Therapies for Alzheimer\u2019s Disease and the Amyloid Cascade Hypothesis. Int. J. Mol. Sci., 24.","DOI":"10.3390\/ijms241914499"},{"key":"ref_44","doi-asserted-by":"crossref","unstructured":"Behl, C. (2024). In 2024, the amyloid-cascade-hypothesis still remains a working hypothesis, no less but certainly no more. Front. Aging Neurosci., 16.","DOI":"10.3389\/fnagi.2024.1459224"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1212\/01.WNL.0000115115.98960.37","article-title":"Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain","volume":"62","author":"Ingelsson","year":"2004","journal-title":"Neurology"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1007\/s00702-006-0575-6","article-title":"The significance of neuroinflammation in understanding Alzheimer\u2019s disease","volume":"113","author":"Eikelenboom","year":"2006","journal-title":"J. Neural. Transm."},{"key":"ref_47","doi-asserted-by":"crossref","unstructured":"Lutshumba, J., Nikolajczyk, B.S., and Bachstetter, A.D. (2021). Dysregulation of Systemic Immunity in Aging and Dementia. Front. Cell Neurosci., 15.","DOI":"10.3389\/fncel.2021.652111"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0197-4580(00)00124-X","article-title":"Inflammation and Alzheimer\u2019s disease","volume":"21","author":"Akiyama","year":"2000","journal-title":"Neurobiol. Aging"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/1742-2094-5-45","article-title":"TNF signaling inhibition in the CNS: Implications for normal brain function and neurodegenerative disease","volume":"5","author":"McCoy","year":"2008","journal-title":"J. Neuroinflamm."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Elbandy, M. (2002). Anti-Inflammatory Effects of Marine Bioactive Compounds and Their Potential as Functional Food Ingredients in the Prevention and Treatment of Neuroinflammatory Disorders. Molecules, 28.","DOI":"10.3390\/molecules28010002"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nrn2620","article-title":"Apolipoprotein E and its receptors in Alzheimer\u2019s disease: Pathways, pathogenesis and therapy","volume":"10","author":"Bu","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_52","unstructured":"GBD 2016 Neurology Collaborators (2019). Global, regional, and national burden of neurological disorders, 1990\u20132016: A systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol., 18, 459\u2013480."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0197-4580(02)00065-9","article-title":"Staging of brain pathology related to sporadic Parkinson\u2019s disease","volume":"24","author":"Braak","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.ejphar.2017.05.042","article-title":"The gut-brain axis in Parkinson\u2019s disease: Possibilities for food-based therapies","volume":"817","author":"Kliest","year":"2017","journal-title":"Eur. J. Pharmacol."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2047-9158-4-1","article-title":"Meta-analyses on prevalence of selected Parkinson\u2019s nonmotor symptoms before and after diagnosis","volume":"4","author":"Chen","year":"2015","journal-title":"Transl. Neurodegener."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1093\/aje\/kwr119","article-title":"A prospective study of bowel movement frequency and risk of Parkinson\u2019s disease","volume":"174","author":"Gao","year":"2011","journal-title":"Am. J. Epidemiol."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1212\/WNL.57.3.456","article-title":"Frequency of bowel movements and the future risk of Parkinson\u2019s disease","volume":"57","author":"Abbott","year":"2001","journal-title":"Neurology"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"1060.1065","DOI":"10.1002\/mds.22534","article-title":"Hyposmia and executive dysfunction as predictors of future Parkinson\u2019s disease: A prospective study","volume":"24","author":"Ponsen","year":"2009","journal-title":"Mov. Disord."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1093\/brain\/awae188","article-title":"Relevance of genetic testing in the gene-targeted trial era: The Rostock Parkinson\u2019s disease study","volume":"147","author":"Westenberger","year":"2024","journal-title":"Brain"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"106078","DOI":"10.1016\/j.parkreldis.2024.106078","article-title":"Towards a biological diagnosis of PD","volume":"122","author":"Chopra","year":"2024","journal-title":"Park. Relat. Disord."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"D1005","DOI":"10.1093\/nar\/gky1120","article-title":"The NHGRI-EBI GWAS Catalog of published genome-wide association studies, targeted arrays and summary statistics 2019","volume":"47","author":"Buniello","year":"2019","journal-title":"Nucleic. Acids Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.bbadis.2010.07.002","article-title":"The intracellular quality control system down-regulates the secretion of amyloidogenic apolipoprotein A-I variants: A possible impact on the natural history of the disease","volume":"1812","author":"Marchesi","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"G\u00f3mez-Benito, M., Granado, N., Garc\u00eda-Sanz, P., Michel, P., Dumoulin, M., and Moratalla, R. (2020). Modeling Parkinson\u2019s Disease with the Alpha-Synuclein Protein. Front. Pharmacol., 11.","DOI":"10.3389\/fphar.2020.00356"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1159\/000531422","article-title":"Parkinson\u2019s Disease: A Tale of Many Players","volume":"32","author":"Pauwels","year":"2023","journal-title":"Med. Princ. Pract."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1111\/j.1471-4159.2009.06150.x","article-title":"On the mechanism of internalization of alpha-synuclein into microglia: Roles of ganglioside GM1 and lipid raft","volume":"110","author":"Park","year":"2009","journal-title":"J. Neurochem."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1196\/annals.1369.003","article-title":"Dopamine quinones activate microglia and induce a neurotoxic gene expression profile: Relationship to methamphetamine-induced nerve ending damage","volume":"1074","author":"Kuhn","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/s41586-018-0824-5","article-title":"Brain regulatory T cells suppress astrogliosis and potentiate neurological recovery","volume":"565","author":"Ito","year":"2019","journal-title":"Nature"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.cell.2009.01.038","article-title":"A Nurr1\/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death","volume":"137","author":"Saijo","year":"2009","journal-title":"Cell"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1172\/JCI58649","article-title":"Multiple sclerosis","volume":"122","author":"Nylander","year":"2012","journal-title":"J. Clin. Investig."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1146\/annurev.immunol.23.021704.115707","article-title":"Immunology of multiple sclerosis","volume":"23","author":"Sospedra","year":"2005","journal-title":"Annu. Rev. Immunol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1146\/annurev.immunol.021908.132710","article-title":"IL-17 and Th17 Cells","volume":"27","author":"Korn","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.jocn.2008.07.072","article-title":"Amyotrophic lateral sclerosis: A 40-year personal perspective","volume":"16","author":"Eisen","year":"2009","journal-title":"J. Clin. Neurosci."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/S0140-6736(22)01272-7","article-title":"Amyotrophic lateral sclerosis","volume":"400","author":"Feldman","year":"2022","journal-title":"Lancet"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Mejzini, R., Flynn, L.L., Pitout, I.L., Fletcher, S., Wilton, S.D., and Akkari, P.A. (2019). ALS Genetics, Mechanisms, and Therapeutics: Where Are We Now?. Front. Neurosci., 13.","DOI":"10.3389\/fnins.2019.01310"},{"key":"ref_75","first-page":"4","article-title":"The microglial-motoneuron dialogue in ALS","volume":"30","author":"Appel","year":"2011","journal-title":"Acta. Myol."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.celrep.2013.06.018","article-title":"A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model","volume":"4","author":"Chiu","year":"2013","journal-title":"Cell Rep."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1523\/JNEUROSCI.0854-15.2016","article-title":"IL-10 Controls Early Microglial Phenotypes and Disease Onset in ALS Caused by Misfolded Superoxide Dismutase 1","volume":"36","author":"Gravel","year":"2016","journal-title":"J. Neurosci."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.bbi.2010.12.008","article-title":"Neuroinflammation modulates distinct regional and temporal clinical responses in ALS mice","volume":"25","author":"Beers","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.nbd.2012.07.008","article-title":"Regulatory T lymphocytes from ALS mice suppress microglia and effector T lymphocytes through different cytokine-mediated mechanisms","volume":"48","author":"Zhao","year":"2012","journal-title":"Neurobiol. Dis."},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Kang, J., and Rivest, S. (2007). MyD88-deficient bone marrow cells accelerate onset and reduce survival in a mouse model of amyotrophic lateral sclerosis. J. Cell Biol., 179.","DOI":"10.1083\/jcb.200705046"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1084\/jem.179.1.269","article-title":"Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD14","volume":"179","author":"Hailman","year":"1994","journal-title":"J. Exp. Med."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.toxlet.2021.11.012","article-title":"The role of Fas-FasL-FADD signaling pathway in arsenic-mediated neuronal apoptosis in vivo and in vitro","volume":"356","author":"Sun","year":"2022","journal-title":"Toxicol. Lett."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1074\/jbc.M804446200","article-title":"Expression of amyotrophic lateral sclerosis-linked SOD1 mutant increases the neurotoxic potential of microglia via TLR2","volume":"284","author":"Liu","year":"2009","journal-title":"J. Biol. Chem."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.nbd.2003.12.012","article-title":"Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: An [11C](R)-PK11195 positron emission tomography study","volume":"15","author":"Turner","year":"2004","journal-title":"Neurobiol. Dis."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"5247","DOI":"10.1038\/s41467-023-40937-z","article-title":"Translocator protein is a marker of activated microglia in rodent models but not human neurodegenerative diseases","volume":"14","author":"Nutma","year":"2023","journal-title":"Nat. Commun."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41582-024-01046-7","article-title":"Immune mechanisms and shared immune targets in neurodegenerative diseases","volume":"21","author":"Weiner","year":"2025","journal-title":"Nat. Rev. Neurol."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"fcaa013","DOI":"10.1093\/braincomms\/fcaa013","article-title":"Monocytes and neutrophils are associated with clinical features in amyotrophic lateral sclerosis","volume":"2","author":"McGill","year":"2020","journal-title":"Brain Commun."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"6733","DOI":"10.1038\/s41467-022-34526-9","article-title":"T cell responses at diagnosis of amyotrophic lateral sclerosis predict disease progression","volume":"13","author":"Yazdani","year":"2022","journal-title":"Nat. Commun."},{"key":"ref_89","doi-asserted-by":"crossref","unstructured":"Yangou, Y., Facer, P., Durrenberger, P., Chessell, I.P., Naylor, A., Bountra, C., Banati, R.R., and Anand, P. (2006). COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells\/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord. BMC Neurol., 6.","DOI":"10.1186\/1471-2377-6-12"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"6565396","DOI":"10.1155\/2020\/6565396","article-title":"Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases","volume":"2020","author":"Sirajudeen","year":"2020","journal-title":"Evid. Based Complement. Altern. Med."},{"key":"ref_91","doi-asserted-by":"crossref","unstructured":"Jia, C., Chai, J., Zhang, S., Sun, Y., He, L., Sang, Z., Chen, D., and Zheng, X. (2025). The Advancements of Marine Natural Products in the Treatment of Alzheimer\u2019s Disease: A Study Based on Cell and Animal Experiments. Mar. Drugs, 23.","DOI":"10.3390\/md23030091"},{"key":"ref_92","doi-asserted-by":"crossref","unstructured":"Silva, J., Alves, C., Soledade, F., Martins, A., Pinteus, S., Gaspar, H., Alfonso, A., and Pedrosa, R. (2023). Marine-Derived Components: Can They Be a Potential Therapeutic Approach to Parkinson\u2019s Disease?. Mar. Drugs, 21.","DOI":"10.3390\/md21080451"},{"key":"ref_93","doi-asserted-by":"crossref","unstructured":"Kemp, D.C., and Ewon, J.Y. (2021). Fish and Shellfish-Derived Anti-Inflammatory Protein Products: Properties and Mechanisms. Molecules, 26.","DOI":"10.3390\/molecules26113225"},{"key":"ref_94","first-page":"2673","article-title":"Review: Taurine: A \"very essential\" amino acid","volume":"18","author":"Ripps","year":"2012","journal-title":"Mol. Vis."},{"key":"ref_95","doi-asserted-by":"crossref","unstructured":"Choi, J.Y., Jang, J.S., Son, D.J., Im, H.-S., Kim, J.Y., Park, J.E., Choi, W.R., Han, S.-B., and Hong, J.T. (2017). Antarctic Krill Oil Diet Protects against Lipopolysaccharide-Induced Oxidative Stress, Neuroinflammation and Cognitive Impairment. Int. J. Mol. Sci., 18.","DOI":"10.3390\/ijms18122554"},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Parolini, C., Bjorndal, B., Busnelli, M., Manzini, M., Ganzetti, G.S., Dellera, F., Ramsvik, M., Bruheim, I., Berge, R.F., and Chiesa, G. (2017). Effect of Dietary Components from Antarctic Krill on Atherosclerosis in apoE-Deficient Mice. Mol. Nutr. Food Res., 61.","DOI":"10.1002\/mnfr.201700098"},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1021\/acs.jafc.8b05841","article-title":"Peptides from Antarctic Krill (Euphausia superba) Improve Osteoarthritis via Inhibiting HIF-2\u03b1-Mediated Death Receptor Apoptosis and Metabolism Regulation in Osteoarthritic Mice","volume":"67","author":"Wang","year":"2019","journal-title":"J. Agric. Food Chem."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"7740","DOI":"10.1039\/D1FO04241F","article-title":"Antarctic krill peptide alleviates liver fibrosis via downregulating the secondary bile acid mediated NLRP3 signaling pathway","volume":"13","author":"Yue","year":"2022","journal-title":"Food Funct."},{"key":"ref_99","doi-asserted-by":"crossref","unstructured":"Zheng, J., Gao, Y., Ding, J., Sun, N., and Lin, S. (2022). Antarctic krill peptides improve scopolamine-induced memory impairment in mice. Food Biosci., 49.","DOI":"10.1016\/j.fbio.2022.101987"},{"key":"ref_100","doi-asserted-by":"crossref","unstructured":"Yang, J., Qi, Y., Zhu, B., and Lin, S. (2024). A Novel Tetrapeptide Ala-Phe-Phe-Pro (AFFP) Derived from Antarctic Krill Prevents Scopolamine-Induced Memory Disorder by Balancing Lipid Metabolism of Mice Hippocampus. Nutrients, 16.","DOI":"10.3390\/nu16071019"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"116592","DOI":"10.1016\/j.foodres.2025.116592","article-title":"Preparation, unique structural characteristics and immunomodulatory effects of peptides from Antarctic krill (Euphausia superba)","volume":"214","author":"Yang","year":"2025","journal-title":"Food Res. Int."},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"103909","DOI":"10.1016\/j.jff.2020.103909","article-title":"Evaluation of sea cucumber peptides-assisted memory activity and acetylation modification in hippocampus of test mice based on scopolamine-induced experimental animal model of memory disorder","volume":"68","author":"Xu","year":"2020","journal-title":"J. Funct. Foods"},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1021\/acs.jafc.1c06475","article-title":"Sea Cucumber Peptides Attenuated the Scopolamine-Induced Memory Impairment in Mice and Rats and the Underlying Mechanism","volume":"70","author":"Lu","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"ref_104","doi-asserted-by":"crossref","unstructured":"Gong, H., and Zhao Mao, X. (2025). Sea Cucumber Hydrolysates Alleviate Cognitive Deficits in D-Galactose-Induced C57BL\/6J Aging Mice Associated with Modulation of Gut Microbiota. Foods, 14.","DOI":"10.3390\/foods14111938"},{"key":"ref_105","doi-asserted-by":"crossref","unstructured":"Ren, Q., Jiang, X., Zhang, S., Gao, X., Paudel, Y.N., Zhang, P., Wang, R., Liu, K., and Jin, M. (2022). Neuroprotective effect of YIAEDAER peptide against Parkinson\u2019s disease like pathology in zebrafish. Biomed. Pharmacother., 147.","DOI":"10.1016\/j.biopha.2022.112629"},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.brainresbull.2018.09.011","article-title":"Astaxanthin attenuates neuroinflammation contributed to the neuropathic pain and motor dysfunction following compression spinal cord injury","volume":"143","author":"Fakhri","year":"2018","journal-title":"Brain Res. Bull."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.biopha.2018.11.043","article-title":"Neuroprotective role of astaxanthin in hippocampal insulin resistance induced by A\u03b2 peptides in animal model of Alzheimer\u2019s disease","volume":"110","author":"Rahman","year":"2019","journal-title":"Biomed. Pharmacother."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Liu, N., Lyiu, X., Zhang, X., Zhang, F., Chen, Y., and Li, G. (2023). Astaxanthin attenuates cognitive deficits in Alzheimer\u2019s disease models by reducing oxidative stress via the SIRT1\/PGC-1\u03b1 signaling pathway. Cell Biosci., 13.","DOI":"10.1186\/s13578-023-01129-w"},{"key":"ref_109","first-page":"160","article-title":"Astaxanthin effectiveness in preventing multiple sclerosis in animal model","volume":"119","author":"Bidaran","year":"2018","journal-title":"Bratisl. Lek. Listy"},{"key":"ref_110","first-page":"565","article-title":"Astaxanthin Reduces Demyelination and Oligodendrocytes Death in A Rat Model of Multiple Sclerosis","volume":"22","author":"Lofti","year":"2021","journal-title":"Cell J."},{"key":"ref_111","doi-asserted-by":"crossref","unstructured":"Wei, H., Gao, Z., Zheng, L., Zhang, C., Liu, Z., Yang, Y., Teng, H., Hou, L., Yin, Y., and Zou, X. (2017). Protective Effects of Fucoidan on A\u03b225-35 and d-Gal-Induced Neurotoxicity in PC12 Cells and d-Gal-Induced Cognitive Dysfunction in Mice. Mar. Drugs, 15.","DOI":"10.3390\/md15030077"},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.etap.2011.12.022","article-title":"Fucoidan, a sulfated polysaccharide from brown algae, improves cognitive impairment induced by infusion of A\u03b2 peptide in rats","volume":"33","author":"Gao","year":"2012","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.ijbiomac.2019.09.243","article-title":"The degraded polysaccharide from Pyropia haitanensis represses amyloid beta peptide-induced neurotoxicity and memory in vivo","volume":"146","author":"Zhang","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_114","doi-asserted-by":"crossref","unstructured":"Park, S.K., Kang, J.Y., Kim, J.M., Yoo, S.K., Han, H.J., Chung, D.H., Kim, D.-O., Kim, G.-H., and Heo, H.J. (2019). Fucoidan-Rich Substances from Ecklonia cava Improve Trimethyltin-Induced Cognitive Dysfunction via Down-Regulation of Amyloid \u03b2 Production\/Tau Hyperphosphorylation. Mar. Drugs, 17.","DOI":"10.3390\/md17100591"},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1039\/C7FO00662D","article-title":"Fucoidan inhibits amyloid-\u03b2-induced toxicity in transgenic Caenorhabditis elegans by reducing the accumulation of amyloid-\u03b2 and decreasing the production of reactive oxygen species","volume":"9","author":"Wang","year":"2018","journal-title":"Food Funct."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"590","DOI":"10.14336\/AD.2017.0831","article-title":"Fucoidan Protects Dopaminergic Neurons by Enhancing the Mitochondrial Function in a Rotenone-induced Rat Model of Parkinson\u2019s Disease","volume":"9","author":"Zhang","year":"2018","journal-title":"Aging Dis."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ejphar.2009.06.015","article-title":"Fucoidan protects against dopaminergic neuron death in vivo and in vitro","volume":"617","author":"Luo","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1111\/cns.12340","article-title":"Therapeutic effects of fucoidan in 6-hydroxydopamine-lesioned rat model of Parkinson\u2019s disease: Role of NADPH oxidase-1","volume":"20","author":"Zhang","year":"2014","journal-title":"CNS Neurosci. Ther."},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/j.1755-5949.2012.00372.x","article-title":"Fucoidan protects against lipopolysaccharide-induced rat neuronal damage and inhibits the production of proinflammatory mediators in primary microglia","volume":"18","author":"Cui","year":"2012","journal-title":"CNS Neurosci. Ther."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.ijbiomac.2015.12.025","article-title":"Neuroprotective effect of fucoidan from Turbinaria decurrens in MPTP intoxicated Parkinsonic mice","volume":"86","author":"Meenakshi","year":"2016","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"120470","DOI":"10.1016\/j.carbpol.2022.120470","article-title":"Fucoidan from Fucus vesiculosus prevents the loss of dopaminergic neurons by alleviating mitochondrial dysfunction through targeting ATP5F1a","volume":"303","author":"Xing","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Yang, X., Zhang, X., Ma, Y., Li, S., Wang, Q., Hong, J.-S., Yu, G., Qi, B., Wang, J., and Liu, C. (2024). Fucoidan ameliorates rotenone-induced Parkinsonism in mice by regulating the microbiota-gut-brain axis. Int. J. Biol. Macromol., 283.","DOI":"10.1016\/j.ijbiomac.2024.137373"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/ptr.2959","article-title":"Amelioration of experimental autoimmune encephalomyelitis in Lewis rats treated with fucoidan","volume":"24","author":"Kim","year":"2010","journal-title":"Phytother. Res."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.jff.2017.10.014","article-title":"hlorotannin-rich fraction from Ishige foliacea brown seaweed prevents the scopolamine-induced memory impairment via regulation of ERK-CREB-BDNF pathway","volume":"40","author":"Um","year":"2018","journal-title":"J. Funct. Foods"},{"key":"ref_125","doi-asserted-by":"crossref","unstructured":"Kim, T.-E., Son, H.J., Lim, D.W., Yoon, M., Lee, J., Kim, Y.T., Han, D., Lee, C., and Um, M.Y. (2020). Memory-enhancing effects of Ishige foliacea extract: In Vitro and in vivo study. J. Food Biochem., 44.","DOI":"10.1111\/jfbc.13162"},{"key":"ref_126","doi-asserted-by":"crossref","unstructured":"Kwon, O.Y., and Lee, S.H. (2021). Ishige okamurae Suppresses Trimethyltin-Induced Neurodegeneration and Glutamate-Mediated Excitotoxicity by Regulating MAPKs\/Nrf2\/HO-1 Antioxidant Pathways. Antioxidants, 10.","DOI":"10.3390\/antiox10030440"},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Yasuda, Y., Tokumatsu, T., Ueda, C., Sakai, M., Sasaki, Y., Norikura, T., Matsui-Yuasa, I., and Kojima-Yuasa, A. (2024). Ecklonia cava Polyphenols Have a Preventive Effect on Parkinson\u2019s Disease through the Activation of the Nrf2-ARE Pathway. Nutrients, 16.","DOI":"10.3390\/nu16132076"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1002\/mds.27326","article-title":"Stool Immune Profiles Evince Gastrointestinal Inflammation in Parkinson\u2019s Disease","volume":"33","author":"Houser","year":"2018","journal-title":"Mov. Disord."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1111\/febs.15217","article-title":"The mutual interplay of gut microbiota, diet and human disease","volume":"287","author":"Illiano","year":"2020","journal-title":"FEBS J."},{"key":"ref_130","doi-asserted-by":"crossref","unstructured":"Chen, Y.-F., Fan, Z.-K., Gao, X., Zhou, F., Guo, X.-F., Sinclair, A.J., and Li, D. (2024). n-3 polyunsaturated fatty acids in phospholipid or triacylglycerol form attenuate nonalcoholic fatty liver disease via mediating cannabinoid receptor 1\/adiponectin\/ceramide pathway. J. Nutr. Biochem., 123.","DOI":"10.1016\/j.jnutbio.2023.109484"},{"key":"ref_131","doi-asserted-by":"crossref","unstructured":"Li, K., Song, X., Li, H., Kuang, X., Liu, S., Liu, R., and Li, D. (2024). Mussel oil is superior to fish oil in preventing atherosclerosis of ApoE-\/-mice. Front. Nutr., 11.","DOI":"10.3389\/fnut.2024.1326421"},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"10709","DOI":"10.1080\/10408398.2022.2084600","article-title":"Health benefits of astaxanthin against age-related diseases of multiple organs: A comprehensive review","volume":"63","author":"Alugoju","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"8038","DOI":"10.1039\/D0FO01176B","article-title":"Docosahexaenoic acid-acylated astaxanthin ester exhibits superior performance over non-esterified astaxanthin in preventing behavioral deficits coupled with apoptosis in MPTP-induced mice with Parkinson\u2019s disease","volume":"11","author":"Wang","year":"2010","journal-title":"Food Funct."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"110762","DOI":"10.1016\/j.brainresbull.2023.110762","article-title":"Astaxanthin ameliorates dopaminergic neuron damage in paraquat-induced SH-SY5Y cells and mouse models of Parkinson\u2019s disease","volume":"202","author":"Wang","year":"2023","journal-title":"Brain Res. Bull."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1743-7075-7-18","article-title":"Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans","volume":"7","author":"Park","year":"2010","journal-title":"Nutr. Metab."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"146","DOI":"10.3390\/md11010146","article-title":"Beneficial effects of marine algal compounds in cosmeceuticals","volume":"11","author":"Thomas","year":"2013","journal-title":"Mar. Drugs"},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s10811-010-9632-5","article-title":"Bioactive compounds in seaweed: Functional food applications and legislation","volume":"23","author":"Holdt","year":"2011","journal-title":"J. Appl. Phycol."},{"key":"ref_138","doi-asserted-by":"crossref","unstructured":"Dimitrova-Shumkovska, J., Krstanoski, L., and Veenman, L. (2020). Potential Beneficial Actions of Fucoidan in Brain and Liver Injury, Disease, and Intoxication-Potential Implication of Sirtuins. Mar. Drugs, 18.","DOI":"10.3390\/md18050242"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"3820","DOI":"10.1039\/D0FO03153D","article-title":"Fucoidan: A promising agent for brain injury and neurodegenerative disease intervention","volume":"12","author":"Wang","year":"2021","journal-title":"Food Funct."},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Hsieh, C.-H., Lu, C.-H., Kuo, Y.-Y., Lin, G.-B., and Chao, C.-Y. (2019). The protective effect of non-invasive low intensity pulsed electric field and fucoidan in preventing oxidative stress-induced motor neuron death via ROCK\/Akt pathway. PLoS ONE, 14.","DOI":"10.1371\/journal.pone.0214100"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"509","DOI":"10.3390\/md13010509","article-title":"Profiling of the molecular weight and structural isomer abundance of macroalgae-derived phlorotannins","volume":"13","author":"Heffernan","year":"2015","journal-title":"Mar. Drugs"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.3109\/13880209.2014.959615","article-title":"New insights into seaweed polyphenols on glucose homeostasis","volume":"53","author":"Murugan","year":"2015","journal-title":"Pharm. Biol."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1080\/10408398.2016.1259209","article-title":"An emerging trend in functional foods for the prevention of cardiovascular disease and diabetes: Marine algal polyphenols","volume":"58","author":"Murray","year":"2018","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.etap.2012.03.006","article-title":"Neuroprotective effects of phlorotannins isolated from a brown alga, Ecklonia cava, against H2O2-induced oxidative stress in murine hippocampal HT22 cells","volume":"34","author":"Kang","year":"2012","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1007\/s12010-012-9545-7","article-title":"Neuroprotective effect of phlorotannin isolated from Ishige okamurae against H2O2-induced oxidative stress in murine hippocampal neuronal cells, HT22","volume":"166","author":"Heo","year":"2012","journal-title":"Appl. Biochem. Biotechnol."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"121","DOI":"10.4196\/kjpp.2019.23.2.121","article-title":"Neuroprotective mechanisms of dieckol against glutamate toxicity through reactive oxygen species scavenging and nuclear factor-like 2\/heme oxygenase-1 pathway","volume":"23","author":"Cui","year":"2019","journal-title":"Korean J. Physiol. Pharmacol."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.intimp.2014.09.019","article-title":"8,8\u2032-Bieckol, isolated from edible brown algae, exerts its anti-inflammatory effects through inhibition of NF-\u03baB signaling and ROS production in LPS-stimulated macrophages","volume":"23","author":"Yang","year":"2014","journal-title":"Int. Immunopharmacol."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s12033-022-00629-3","article-title":"Dioxinodehydroeckol: A Potential Neuroprotective Marine Compound Identified by In Silico Screening for the Treatment and Management of Multiple Brain Disorders","volume":"66","author":"Ahmad","year":"2024","journal-title":"Mol. Biotechnol."},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Gao, C., Gong, N., Chen, F., Hu, S., Zhou, Q., and Gao, X. (2024). The Effects of Astaxanthin on Metabolic Syndrome: A Comprehensive Review. Mar. Drugs, 23.","DOI":"10.3390\/md23010009"},{"key":"ref_150","doi-asserted-by":"crossref","unstructured":"Nouchi, R., Suiko, T., Kimura, E., Takenada, H., Murakoshi, M., Uchiyama, A., Aono, M., and Kawashima, R. (2020). Effects of Lutein and Astaxanthin Intake on the Improvement of Cognitive Functions among Healthy Adults: A Systematic Review of Randomized Controlled Trials. Nutrients, 12.","DOI":"10.3390\/nu12030617"},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1007\/s12325-025-03125-7","article-title":"Astaxanthin (AstaReal\u00ae) Improved Acute and Chronic Digital Eye Strain in Children: A Randomized Double-Blind Placebo-Controlled Trial","volume":"42","author":"Hecht","year":"2025","journal-title":"Adv. Ther."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1080\/1028415X.2020.1735143","article-title":"Potential treatment of Parkinson\u2019s disease with omega-3 polyunsaturated fatty acids","volume":"25","author":"Li","year":"2022","journal-title":"Nutr. Neurosci."}],"container-title":["Marine Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-3397\/23\/11\/446\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T12:06:04Z","timestamp":1763640364000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-3397\/23\/11\/446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,20]]},"references-count":152,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2025,11]]}},"alternative-id":["md23110446"],"URL":"https:\/\/doi.org\/10.3390\/md23110446","relation":{},"ISSN":["1660-3397"],"issn-type":[{"value":"1660-3397","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,20]]}}}