{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T15:57:27Z","timestamp":1778428647101,"version":"3.51.4"},"reference-count":48,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:00:00Z","timestamp":1768348800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science and Technology Innovation Team Project of Liaoning Provincial Department of Education","award":["LJ222410161077"],"award-info":[{"award-number":["LJ222410161077"]}]},{"name":"Liaoning Provincial Key R&amp;D Program for Industrial Technology Innovation","award":["2024JH2\/102400054"],"award-info":[{"award-number":["2024JH2\/102400054"]}]},{"name":"The Innovation and Entrepreneurship Plan of Science and Technology Talent of Dalian","award":["2022RG09"],"award-info":[{"award-number":["2022RG09"]}]},{"name":"Open Project of National-Local Joint Engineering Research Center for Drug-Research and Devel-opment (R &amp; D) of Neurodegenerative Diseases","award":["2022GCYJZX-YB01"],"award-info":[{"award-number":["2022GCYJZX-YB01"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Fucoidan, a complex sulfated polysaccharide derived from marine brown seaweeds, exhibits broad biological activities, including anticoagulant, antitumor, antiviral, anti-inflammatory and lipid-lowering effects. Fucoidan confers neuroprotection in animal models of a broad spectrum of brain disorders such as Parkinson\u2019s disease (PD) and depression. However, the effect of fucoidan on gut-derived neuroinflammation and associated behavioral changes has been scarcely investigated. In comparison to fucoidan from other brown seaweeds, that from Fucus vesiculosus exhibited a better neuroprotective effect in vivo and more potent radical scavenging activity in vitro. Fucoidan from Laminaria japonica ameliorates behavioral disorders related to acute ulcerative colitis (UC) in aged mice. It is of interest to assess the effects of fucoidan administration on intestinal and brain inflammation in the acute colitis mouse model. Fucoidan treatment ameliorated DSS-induced intestinal pathology, reduced the inflammatory mediator expression in the gut and brain, and activated intestinal macrophages and cortical microglia in the UC mice. It also protected the intestinal mucosal barrier and blood\u2013brain barrier as well as prevented neuronal damage, while alleviating anxiety-like behavior in UC mice. These results suggest fucoidan supplementation may help prevent brain disorders, such as depression and PD, potentially involving gut\u2013brain axis-related mechanisms, as fucoidan suppresses gut-derived neuroinflammation.<\/jats:p>","DOI":"10.3390\/md24010042","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T15:47:37Z","timestamp":1768405657000},"page":"42","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Fucoidan Extracted from Fucus vesiculosus Ameliorates Colitis-Associated Neuroinflammation and Anxiety-like Behavior in Adult C57BL\/6 Mice"],"prefix":"10.3390","volume":"24","author":[{"given":"Xiaoyu","family":"Song","sequence":"first","affiliation":[{"name":"Department of Medical Physiology, School of Basic Medical Science, Dalian Medical University, Dalian 116044, 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China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8063-5486","authenticated-orcid":false,"given":"Yangting","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Medical Physiology, School of Basic Medical Science, Dalian Medical University, Dalian 116044, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Medical Physiology, School of Basic Medical Science, Dalian Medical University, Dalian 116044, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanjie","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pathogen Biology and Microecology (Pathogen Biology Laboratory), School of Basic Medical Science, Dalian Medical University, Dalian 116044, 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inflammasome and cell death in response to cytoplasmic DNA","volume":"458","author":"Yu","year":"2009","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/s41582-019-0174-4","article-title":"Immunoneuropsychiatry\u2014Novel perspectives on brain disorders","volume":"15","author":"Pape","year":"2019","journal-title":"Nat. Rev. Neurol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neures.2013.10.004","article-title":"Neuroinflammation: The role and consequences","volume":"79","author":"Lyman","year":"2014","journal-title":"Neurosci. Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jpsychores.2017.07.015","article-title":"Increased incidence of psychiatric disorders in immune-mediated inflammatory disease","volume":"101","author":"Marrie","year":"2017","journal-title":"J. Psychosom. Res."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3748\/wjg.v20.i1.91","article-title":"Inflammatory bowel disease: Pathogenesis","volume":"20","author":"Zhang","year":"2014","journal-title":"World J. Gastroenterol. WJG"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1080\/13651501.2017.1306081","article-title":"Association between psychological measures with inflammatory anddisease-related markers of inflammatory bowel disease","volume":"21","author":"Dempsey","year":"2017","journal-title":"Int. J. Psychiatry Clin. Pract."},{"key":"ref_7","first-page":"S331","article-title":"Inflammatory bowel diseases and Parkinson\u2019s disease","volume":"9","author":"Brudek","year":"2019","journal-title":"J. Park. Dis."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12974-022-02431-z","article-title":"Recruitment of \u03b14\u03b27 monocytes and neutrophils to the brain in experimental colitis is associated with elevated cytokines and anxiety-like behavior","volume":"19","author":"Cluny","year":"2022","journal-title":"J. Neuroinflamm."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.schres.2019.08.005","article-title":"The effect of minocycline on amelioration of cognitive deficits and pro-inflammatory cytokines levels in patients with schizophrenia","volume":"212","author":"Zhang","year":"2019","journal-title":"Schizophr. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/nrgastro.2016.191","article-title":"The mucosal immune system: Master regulator of bidirectional gut\u2013brain communications","volume":"14","author":"Powell","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Mou, Y., Du, Y., Zhou, L., Yue, J., Hu, X., Liu, Y., Chen, S., Lin, X., Zhang, G., and Xiao, H. (2022). Gut microbiota interact with the brain through systemic chronic inflammation: Implications on neuroinflammation, neurodegeneration, and aging. Front. Immunol., 13.","DOI":"10.3389\/fimmu.2022.796288"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.ijbiomac.2019.11.191","article-title":"Fucoidan, a natural biopolymer in cancer combating: From edible algae to nanocarrier tailoring","volume":"147","author":"Etman","year":"2020","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Besednova, N.N., Zaporozhets, T.S., Kuznetsova, T.A., Makarenkova, I.D., Kryzhanovsky, S.P., Fedyanina, L.N., and Ermakova, S.P. (2020). Extracts and marine algae polysaccharides in therapy and prevention of inflammatory diseases of the intestine. Mar. Drugs, 18.","DOI":"10.3390\/md18060289"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.jep.2017.09.014","article-title":"Low molecular weight fucoidan ameliorates hindlimb ischemic injury in type 2 diabetic rats","volume":"210","author":"Wang","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"14864","DOI":"10.1021\/acs.jafc.2c06417","article-title":"Fucoidan ameliorated dextran sulfate sodium-induced ulcerative colitis by modulating gut microbiota and bile acid metabolism","volume":"70","author":"Liu","year":"2022","journal-title":"J. Agric. Food Chem."},{"key":"ref_16","doi-asserted-by":"crossref","unstructured":"Ahmad, T., Ishaq, M., Karpiniec, S., Park, A., Stringer, D., Singh, N., Ratanpaul, V., Wolfswinkel, K., Fitton, H., and Caruso, V. (2022). Oral Macrocystis pyrifera fucoidan administration exhibits anti-inflammatory and antioxidant properties and improves DSS-induced colitis in C57BL\/6J mice. Pharmaceutics, 14.","DOI":"10.3390\/pharmaceutics14112383"},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Apostolova, E., Lukova, P., Baldzhieva, A., Katsarov, P., Nikolova, M., Iliev, I., Peychev, L., Trica, B., Oancea, F., and Delattre, C. (2020). Immunomodulatory and anti-inflammatory effects of fucoidan: A review. Polymers, 12.","DOI":"10.3390\/polym12102338"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"120470","DOI":"10.1016\/j.carbpol.2022.120470","article-title":"Fucoidan from Fucus vesiculosus prevents the loss of dopaminergic neurons by alleviating mitochondrial dysfunction through targeting ATP5F1a","volume":"303","author":"Xing","year":"2023","journal-title":"Carbohydr. Polym."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Obluchinskaya, E.D., Pozharitskaya, O.N., and Shikov, A.N. (2022). In vitro anti-inflammatory activities of fucoidans from five species of brown seaweeds. Mar. Drugs, 20.","DOI":"10.3390\/md20100606"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"118614","DOI":"10.1016\/j.jep.2024.118614","article-title":"Fucoidan from Laminaria japonica protects renal tubular epithelial cells from uric acid induced NLRP3-mediated pyroptosis through inhibition of NF-\u03baB pathway","volume":"335","author":"Tan","year":"2024","journal-title":"J. Ethnopharmacol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/nrd.2018.97","article-title":"Targeting the NLRP3 inflammasome in inflammatory diseases","volume":"17","author":"Mangan","year":"2018","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1007\/s00401-021-02370-8","article-title":"Analyzing microglial phenotypes across neuropathologies: A practical guide","volume":"142","author":"Schwabenland","year":"2021","journal-title":"Acta neuropathologica"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"e2115539118","DOI":"10.1073\/pnas.2115539118","article-title":"Altered synaptic connectivity and brain function in mice lacking microglial adapter protein Iba1","volume":"118","author":"Lituma","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1161\/STROKEAHA.122.036946","article-title":"Neuroinflammation, stroke, blood-brain barrier dysfunction, and imaging modalities","volume":"53","author":"Dijkhuizen","year":"2022","journal-title":"Stroke"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.pneurobio.2017.12.001","article-title":"Focusing on claudin-5: A promising candidate in the regulation of BBB to treat ischemic stroke","volume":"161","author":"Lv","year":"2018","journal-title":"Prog. Neurobiol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrn3009","article-title":"The role of ubiquitylation in nerve cell development","volume":"12","author":"Kawabe","year":"2011","journal-title":"Nat. Rev. Neurosci."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1007\/s12035-015-9122-5","article-title":"Novel insights into NeuN: From neuronal marker to splicing regulator","volume":"53","author":"Duan","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Luthuli, S., Wu, S., Cheng, Y., Zheng, X., Wu, M., and Tong, H. (2019). Therapeutic effects of fucoidan: A review on recent studies. Mar. Drugs, 17.","DOI":"10.3390\/md17090487"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"134397","DOI":"10.1016\/j.ijbiomac.2024.134397","article-title":"Therapeutic potential of fucoidan in central nervous system disorders: A systematic review","volume":"277","author":"Yang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"137373","DOI":"10.1016\/j.ijbiomac.2024.137373","article-title":"Fucoidan ameliorates rotenone-induced Parkinsonism in mice by regulating the microbiota-gut-brain axis","volume":"283","author":"Yang","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Han, Y.-S., Lee, J.H., and Lee, S.H. (2019). Fucoidan suppresses mitochondrial dysfunction and cell death against 1-methyl-4-phenylpyridinum-induced neuronal cytotoxicity via regulation of PGC-1\u03b1 expression. Mar. Drugs, 17.","DOI":"10.3390\/md17090518"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ejphar.2009.06.015","article-title":"Fucoidan protects against dopaminergic neuron death in vivo and in vitro","volume":"617","author":"Luo","year":"2009","journal-title":"Eur. J. Pharmacol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1111\/cns.12340","article-title":"Therapeutic effects of fucoidan in 6-hydroxydopamine-lesioned rat model of Parkinson\u2019s disease: Role of NADPH oxidase-1","volume":"20","author":"Zhang","year":"2014","journal-title":"CNS Neurosci. Ther."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"590","DOI":"10.14336\/AD.2017.0831","article-title":"Fucoidan protects dopaminergic neurons by enhancing the mitochondrial function in a rotenone-induced rat model of Parkinson\u2019s disease","volume":"9","author":"Zhang","year":"2018","journal-title":"Aging Dis."},{"key":"ref_35","doi-asserted-by":"crossref","unstructured":"Bai, X., Zhang, E., Hu, B., Liang, H., Song, S., and Ji, A. (2020). Study on absorption mechanism and tissue distribution of fucoidan. Molecules, 25.","DOI":"10.3390\/molecules25051087"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.intimp.2019.05.013","article-title":"L-Fucose ameliorates DSS-induced acute colitis via inhibiting macrophage M1 polarization and inhibiting NLRP3 inflammasome and NF-kB activation","volume":"73","author":"He","year":"2019","journal-title":"Int. Immunopharmacol."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"14199","DOI":"10.1021\/acs.jafc.4c03039","article-title":"Ameliorated effects of Fucoidan on dextran sulfate sodium-induced ulcerative colitis and accompanying anxiety and depressive behaviors in aged C57BL\/6 mice","volume":"72","author":"Li","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"122421","DOI":"10.1016\/j.carbpol.2024.122421","article-title":"Fucoidan modulates gut microbiota and immunity in Peyer\u2019s patches against inflammatory bowel disease","volume":"342","author":"Li","year":"2024","journal-title":"Carbohydr. Polym."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"48","DOI":"10.5056\/jnm18087","article-title":"Brain-gut-microbiota axis in Alzheimer\u2019s disease","volume":"25","author":"Kowalski","year":"2019","journal-title":"J. Neurogastroenterol. Motil."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"8962","DOI":"10.1038\/s41598-025-94312-7","article-title":"Antioxidant and anticancer properties of fucoidan isolated from Saccharina Japonica brown algae","volume":"15","author":"Yue","year":"2025","journal-title":"Sci. Rep."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nrd.2015.21","article-title":"From blood\u2013brain barrier to blood\u2013brain interface: New opportunities for CNS drug delivery","volume":"15","author":"Banks","year":"2016","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1016\/j.apsb.2022.02.002","article-title":"Why 90% of clinical drug development fails and how to improve it?","volume":"12","author":"Sun","year":"2022","journal-title":"Acta Pharm. Sin. B"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1084\/jem.20180794","article-title":"Microbiome\u2013microglia connections via the gut\u2013brain axis","volume":"216","author":"Schlachetzki","year":"2019","journal-title":"J. Exp. Med."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1038\/s41575-021-00423-7","article-title":"Enteric glial biology, intercellular signalling and roles in gastrointestinal disease","volume":"18","author":"Seguella","year":"2021","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s41419-019-1716-9","article-title":"Microglia-derived TNF-\u03b1 mediates endothelial necroptosis aggravating blood brain\u2013barrier disruption after ischemic stroke","volume":"10","author":"Chen","year":"2019","journal-title":"Cell Death Dis."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/nri2171","article-title":"Evolving functions of endothelial cells in inflammation","volume":"7","author":"Pober","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"156057","DOI":"10.1016\/j.phymed.2024.156057","article-title":"Vinegar-processed Schisandra Chinensis enhanced therapeutic effects on colitis-induced depression through tryptophan metabolism","volume":"135","author":"Zhang","year":"2024","journal-title":"Phytomedicine"},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"104928","DOI":"10.1016\/j.neubiorev.2022.104928","article-title":"Reliability of common mouse behavioural tests of anxiety: A systematic review and meta-analysis on the effects of anxiolytics","volume":"143","author":"Rosso","year":"2022","journal-title":"Neurosci. Biobehav. Rev."}],"container-title":["Marine Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-3397\/24\/1\/42\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T06:14:17Z","timestamp":1768544057000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-3397\/24\/1\/42"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,14]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,1]]}},"alternative-id":["md24010042"],"URL":"https:\/\/doi.org\/10.3390\/md24010042","relation":{},"ISSN":["1660-3397"],"issn-type":[{"value":"1660-3397","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,14]]}}}