{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T23:20:02Z","timestamp":1773444002362,"version":"3.50.1"},"reference-count":230,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"crossref","award":["ANR-21-CE43-0015"],"award-info":[{"award-number":["ANR-21-CE43-0015"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Southern Province of New Caledonia"},{"name":"Government of New Caledonia"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Staphylococcus aureus is a major opportunistic pathogen responsible for a wide spectrum of human infections, including severe and difficult-to-treat cases. The emergence of multidrug-resistant strains limits the efficacy of conventional antibiotic therapies and poses a significant global public health challenge. In this context, the search for novel antibiotics has intensified, with increasing interest in marine resources, an ecosystem still largely underexplored. Marine bacteria produce a vast array of secondary metabolites with unique structures and potentially novel modes of antibacterial action. Several compounds isolated from marine bacterial strains have demonstrated promising activity against multidrug-resistant S. aureus, including antivirulence effects such as biofilm formation and Quorum-Sensing inhibition. This review explores the potential of marine bacteria as a source of new antibiotics against S. aureus, discusses both classical and advanced strategies for the discovery of bioactive molecules, and highlights the scientific and technological challenges involved in translating these findings into clinical applications.<\/jats:p>","DOI":"10.3390\/md24010044","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T16:21:13Z","timestamp":1768494073000},"page":"44","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Marine Bacteria as a Source of Antibiotics Against Staphylococcus aureus: Natural Compounds, Mechanisms of Action, and Discovery Strategies"],"prefix":"10.3390","volume":"24","author":[{"given":"C\u00e9phas","family":"Xuma","sequence":"first","affiliation":[{"name":"Group BIOactivities of NAtural Products and Derivatives (BIONA), Institut Pasteur of New Caledonia, Member of the Pasteur Network, BP 61, 98845 Noumea Cedex, New Caledonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2914-7597","authenticated-orcid":false,"given":"Alexandre","family":"Bourles","sequence":"additional","affiliation":[{"name":"Medical and Environmental Bacteriology Group, Institut Pasteur of New Caledonia, Member of the Pasteur Network, BP 61, 98845 Noumea Cedex, New Caledonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Colot","sequence":"additional","affiliation":[{"name":"Medical and Environmental Bacteriology Group, Institut Pasteur of New Caledonia, Member of the Pasteur Network, BP 61, 98845 Noumea Cedex, New Caledonia"},{"name":"Gaston-Bourret Territorial Hospital Center of New Caledonia, BP J5, 98 849 Noumea Cedex, New Caledonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Guentas","sequence":"additional","affiliation":[{"name":"Institut de Sciences Exactes et Appliqu\u00e9es (ISEA), University of New Caledonia, BP R4, 98 851 Noumea Cedex, New Caledonia"},{"name":"Centre for Marine Bioproducts Development, Flinders University, Sturt Road, Health Sciences Building, Bedford Park 5042, South Australia, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8091-8521","authenticated-orcid":false,"given":"Mariko","family":"Matsui","sequence":"additional","affiliation":[{"name":"Group BIOactivities of NAtural Products and Derivatives (BIONA), Institut Pasteur of New Caledonia, Member of the Pasteur Network, BP 61, 98845 Noumea Cedex, New Caledonia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,1,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1128\/CMR.00134-14","article-title":"Staphylococcus aureus Infections: Epidemiology, Pathophysiology, Clinical Manifestations, and Management","volume":"28","author":"Tong","year":"2015","journal-title":"Clin. 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