{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T20:15:22Z","timestamp":1782245722243,"version":"3.54.5"},"reference-count":163,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CNPq (Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico)-Brazil","award":["306417\/2025-1"],"award-info":[{"award-number":["306417\/2025-1"]}]},{"name":"FAPERJ (Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro)-Brazil","award":["E-26\/201.141\/2022"],"award-info":[{"award-number":["E-26\/201.141\/2022"]}]},{"name":"FAPERJ (Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro)-Brazil","award":["E-26\/210.434\/2024"],"award-info":[{"award-number":["E-26\/210.434\/2024"]}]},{"name":"Ministerio de Ciencia e Innovaci\u00f3n Gobierno de Canarias: PROMOTUR Turismo de Canarias","award":["PROMOTUR_SP3"],"award-info":[{"award-number":["PROMOTUR_SP3"]}]},{"name":"Ministerio de Ciencia e Innovaci\u00f3n Gobierno de Canarias: PROMOTUR Turismo de Canarias","award":["ProID2024010033"],"award-info":[{"award-number":["ProID2024010033"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>The concept of \u201cSmart Secondary Metabolites\u201d is introduced here to describe a privileged class of natural products defined by structural originality, biosynthetic adaptability, and broad interaction potential with biological systems. Elatol, a halogenated sesquiterpene chiefly produced by Laurencia red seaweeds and occasionally accumulated by their consumers, exemplifies this concept with remarkable clarity. Its biosynthesis unfolds from farnesyl diphosphate via \u03b3-bisabolane cations, bromochlorination, and stereoselective cyclization to chamigrene scaffolds, generating both (+)- and (\u2013)-enantiomers, two metabolites with clearly distinct potential ecological roles and pharmacological profiles. This review synthesizes the current state of knowledge on elatol\u2019s distribution, biosynthetic origins, ecological relevance, and therapeutic potential. Elatol serves as a multifunctional chemical mediator, fulfilling defensive, communicative, and regulatory roles whose intensity shifts in response to herbivory, biofouling, temperature, and salinity. In parallel, its potent activities against infectious, metabolic, and neoplastic diseases highlight its growing value as a drug lead, reflected in a rising number of patent claims. Altogether, elatol emerges as a model Smart Secondary Metabolite whose ecological sophistication and biochemical versatility position it as a promising scaffold for marine-derived drug discovery.<\/jats:p>","DOI":"10.3390\/md24020061","type":"journal-article","created":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T16:12:37Z","timestamp":1770048757000},"page":"61","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Smart Secondary Metabolites in Marine Environments: The Case of Elatol"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9126-3778","authenticated-orcid":false,"given":"Ang\u00e9lica R.","family":"Soares","sequence":"first","affiliation":[{"name":"Grupo de Produtos Naturais de Organismos Aqu\u00e1ticos (GPNOA), Instituto de Biodiversidade e Sustentabilidade (NUPEM), Universidade Federal do Rio de Janeiro (UFRJ), Av. S\u00e3o Jos\u00e9 do Barreto 764, S\u00e3o Jos\u00e9 do Barreto, Maca\u00e9 27965-045, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6811-1581","authenticated-orcid":false,"given":"Nathalia","family":"Nocchi","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Bio-Org\u00e1nica Antonio Gonz\u00e1lez (IUBO AG), Universidad de La Laguna (ULL), Avenida Astrof\u00edsico Francisco S\u00e1nchez 2, 38206 La Laguna, Tenerife, Spain"},{"name":"Biotecnolog\u00eda Marina, IUBO-ULL, Unidad Asociada al IPNA-CSIC, 38206 La Laguna, Tenerife, Spain"},{"name":"Servicio General de Apoyo a la Investigaci\u00f3n (SEGAI), Universidad de La Laguna, Avenida Astrof\u00edsico Francisco S\u00e1nchez s\/n, 38200 La Laguna, Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8886-7519","authenticated-orcid":false,"given":"Ana R.","family":"D\u00edaz-Marrero","sequence":"additional","affiliation":[{"name":"Biotecnolog\u00eda Marina, IUBO-ULL, Unidad Asociada al IPNA-CSIC, 38206 La Laguna, Tenerife, Spain"},{"name":"Instituto de Productos Naturales y Agrobiolog\u00eda (IPNA), Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Avenida Astrof\u00edsico Francisco S\u00e1nchez 3, 38206 La Laguna, Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7576-226X","authenticated-orcid":false,"given":"Renato C.","family":"Pereira","sequence":"additional","affiliation":[{"name":"Departament of Marine Biology, Biology Institute, Federal Fluminense University\u2014UFF, Niter\u00f3i 21941-590, Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0805-8317","authenticated-orcid":false,"given":"Jos\u00e9 J.","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Instituto Universitario de Bio-Org\u00e1nica Antonio Gonz\u00e1lez (IUBO AG), Universidad de La Laguna (ULL), Avenida Astrof\u00edsico Francisco S\u00e1nchez 2, 38206 La Laguna, Tenerife, Spain"},{"name":"Biotecnolog\u00eda Marina, IUBO-ULL, Unidad Asociada al IPNA-CSIC, 38206 La Laguna, Tenerife, Spain"},{"name":"Departamento de Qu\u00edmica Org\u00e1nica, Universidad de La Laguna (ULL), Avenida Astrof\u00edsico Francisco S\u00e1nchez s\/n, 38203 La Laguna, Tenerife, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,1]]},"reference":[{"key":"ref_1","unstructured":"Institute of Pharmaceutical Sciences, University of Graz (2025, November 30). 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