{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:48:50Z","timestamp":1792082930181,"version":"4.4.0"},"reference-count":30,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T00:00:00Z","timestamp":1770249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22477021"],"award-info":[{"award-number":["22477021"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22177023"],"award-info":[{"award-number":["22177023"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Ulcerative colitis (UC) is an inflammatory bowel disease characterized by recurrent inflammation of the colonic mucosa, and there is currently a lack of safe and effective treatment drugs. Resorcylic acid lactones (RALs) are a natural product that have been reported to have anti-inflammatory effects. However, the mechanism of whether RALs can treat UC and their anti-inflammatory effects remains underexplored. In this study, three new RAL derivatives, Penicillactones A\u2013C (1\u20133), along with seven known analogs (4\u201310), were isolated from the marine fungus Penicillium sp. HN20. The structures of compounds 1\u20133 were elucidated by spectroscopic methods, 13C NMR theoretical calculations, and ECD analysis. Among these, compound 4 exhibited potent anti-inflammatory activity in LPS-stimulated RAW 264.7 macrophages. In a dextran sulfate sodium (DSS)-induced UC model, compound 4 alleviated body weight loss, disease activity, colon shortening, and spleen enlargement, and protected intestinal epithelial integrity. Mechanistic studies revealed that compound 4 primarily exerts its effects by downregulating the Mitogen-Activated Protein Kinase\/Extracellular Signal-Regulated Kinase (MAPK\/ERK) signaling pathway, inhibiting pro-inflammatory cytokine production. Collectively, these findings provide the first evidence that marine-derived RAL derivatives exert anti-inflammatory effects by inhibiting the MAPK\/ERK pathway, highlighting compound 4 as a promising therapeutic candidate for inflammation and UC.<\/jats:p>","DOI":"10.3390\/md24020069","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T11:13:01Z","timestamp":1770289981000},"page":"69","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Anti-Inflammatory Effects of Marine-Derived Resorcylic Acid Lactone Derivatives in Ulcerative Colitis via the MAPK\/ERK Pathway"],"prefix":"10.3390","volume":"24","author":[{"given":"Xuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, China"},{"name":"Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, School of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China"},{"name":"Hainan Provincial International Joint Research Center for Comprehensive Utilization and Efficient Conversion of Tropical Medicinal Resources, Haikou 571158, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tuxiang","family":"Mo","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, China"},{"name":"Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, School of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China"},{"name":"Hainan Provincial International Joint Research Center for Comprehensive Utilization and Efficient Conversion of Tropical Medicinal Resources, Haikou 571158, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuyue","family":"Qin","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, China"},{"name":"Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, School of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China"},{"name":"Hainan Provincial International Joint Research Center for Comprehensive Utilization and Efficient Conversion of Tropical Medicinal Resources, Haikou 571158, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiling","family":"Le","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, China"},{"name":"Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, School of Chemistry and 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Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, China"},{"name":"Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, School of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China"},{"name":"Hainan Provincial International Joint Research Center for Comprehensive Utilization and Efficient Conversion of Tropical Medicinal Resources, Haikou 571158, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiling","family":"Yi","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, China"},{"name":"Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, School of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China"},{"name":"Hainan Provincial International Joint Research Center for Comprehensive 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Tropical Medicinal Plant Chemistry of Hainan Province, School of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China"},{"name":"Hainan Provincial International Joint Research Center for Comprehensive Utilization and Efficient Conversion of Tropical Medicinal Resources, Haikou 571158, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6729-0597","authenticated-orcid":false,"given":"Guangying","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, China"},{"name":"Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, School of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China"},{"name":"Hainan Provincial International Joint Research Center for Comprehensive Utilization and Efficient Conversion of Tropical Medicinal Resources, 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