{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T15:27:43Z","timestamp":1771255663913,"version":"3.50.1"},"reference-count":31,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T00:00:00Z","timestamp":1771027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Special Project for Marine Economic Development of the Department of Natural Resources of Guangdong Province","award":["(GDNRC [2024]25)"],"award-info":[{"award-number":["(GDNRC [2024]25)"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Three previously uncharacterized lactones, namely penicianstinoid L (1), talaromyketide J (2) and peniciisocoumarin K (3), along with twenty-eight known compounds (4\u201331), were yielded from the mangrove-derived fungus Talaromyces sp. SCSIO41445, collected from Mangrove Park (NARA), Sri Lanka. Their structures were established by HRESIMS and NMR spectroscopic analysis (including 1H and 13C NMR, HSQC, and HMBC), with the stereostructures of 2 and 3 being confirmed by single-crystal X-ray crystallographic analysis. Furthermore, compounds 1\u201331 were evaluated in terms of their neuraminidase (NA) inhibitory activities. These bioassay results revealed that three lactones (11, 15, and 16) of them exerted NA inhibitory effects, with IC50 values of 46.66 \u00b1 2.31, 20.78 \u00b1 1.89, and 34.14 \u00b1 2.56 \u00b5M, respectively. Moreover, molecular docking analysis demonstrated the potential of these compounds to inhibit NA enzymes, revealing specific interactions between the compounds and target proteins.<\/jats:p>","DOI":"10.3390\/md24020080","type":"journal-article","created":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T14:55:47Z","timestamp":1771253747000},"page":"80","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diverse and Bioactive Lactones from the Sri Lankan Mangrove-Derived Fungus Talaromyces sp. SCSIO41445"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2895-6464","authenticated-orcid":false,"given":"Parakkrama","family":"Wijerathna","sequence":"first","affiliation":[{"name":"State Key Laboratory of Tropical Oceanography\/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2452-8988","authenticated-orcid":false,"given":"Xinqi","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Tropical Oceanography\/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Tropical Oceanography\/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yufan","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Tropical Oceanography\/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Cai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Tropical Oceanography\/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China"},{"name":"Sanya Institute of Ocean Eco-Environmental Engineering, Sanya 572000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengjing","family":"Cong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Tropical Oceanography\/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2750-7808","authenticated-orcid":false,"given":"Ying","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Tropical Oceanography\/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lalith","family":"Jayasinghe","sequence":"additional","affiliation":[{"name":"National Institute of Fundamental Studies, Hantana Road, Kandy 20000, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8327-3108","authenticated-orcid":false,"given":"Yonghong","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Tropical Oceanography\/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3176-6888","authenticated-orcid":false,"given":"Disna","family":"Ratnasekera","sequence":"additional","affiliation":[{"name":"Department of Agricultural Biology, Faculty of Agriculture, University of Ruhuna, Matara 81100, Sri Lanka"},{"name":"The China\u2013Sri Lanka Joint Center for Education and Research, University of Ruhuna, Matara 81100, Sri Lanka"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9601-4869","authenticated-orcid":false,"given":"Xuefeng","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Tropical Oceanography\/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"},{"name":"The China\u2013Sri Lanka Joint Center for Education and Research, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,2,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13213-012-0442-7","article-title":"Biodiversity and biotechnological potential of microorganisms from mangrove ecosystems: A review","volume":"63","author":"Thatoi","year":"2012","journal-title":"Ann. 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