{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T17:54:39Z","timestamp":1781200479949,"version":"3.54.1"},"reference-count":26,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hainan Provincial Major Science and Technology Project","award":["ZDKJ2021028"],"award-info":[{"award-number":["ZDKJ2021028"]}]},{"name":"Strategic Priority Research Program of the Chinese Academy of Sciences","award":["XDB1060401"],"award-info":[{"award-number":["XDB1060401"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Nine new mycophenolic acid derivatives, penicacids O\u2013W (1\u20139), two first-time reported natural products (10, 11), and five known compounds (12\u201316), were isolated from a marine-derived fungus Penicillium senticosum RCDB005 found in a South China Sea sediment sample. Their structures were determined using NMR, HRESIMS, and optical rotatory dispersion (ORD) spectra, electronic circular dichroism (ECD) calculations, X-ray crystallography, and modified Mosher\u2019s methods. Eight of these compounds were evaluated for anti-proliferative effects against nine human cancer cell lines and the IC50 values ranged from nM to \u03bcM levels. Compounds 5, 7\u20139 showed potent inhibition activity against MOLM-13 acute myeloid leukemia cells with IC50 values between 0.13 and 1.13 \u03bcM.<\/jats:p>","DOI":"10.3390\/md24030108","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T08:26:19Z","timestamp":1773390379000},"page":"108","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Novel Marine Fungus-Derived Mycophenolic Acids That Inhibit Acute Myeloid Leukemia Cell Proliferation"],"prefix":"10.3390","volume":"24","author":[{"given":"Guangli","family":"Deng","sequence":"first","affiliation":[{"name":"Research Center for Deepsea Bioresources, Sanya 572025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wu","family":"Ruan","sequence":"additional","affiliation":[{"name":"Research Center for Deepsea Bioresources, Sanya 572025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qun","family":"Li","sequence":"additional","affiliation":[{"name":"Research Center for Deepsea Bioresources, Sanya 572025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8388-5718","authenticated-orcid":false,"given":"Qingyun","family":"Peng","sequence":"additional","affiliation":[{"name":"Research Center for Deepsea Bioresources, Sanya 572025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunan","family":"Liu","sequence":"additional","affiliation":[{"name":"Research Center for Deepsea Bioresources, Sanya 572025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingbin","family":"Lin","sequence":"additional","affiliation":[{"name":"Research Center for Deepsea Bioresources, Sanya 572025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"Research Center for Deepsea Bioresources, Sanya 572025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1849-681X","authenticated-orcid":false,"given":"Qianqian","family":"Shen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangrong","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6702-5366","authenticated-orcid":false,"given":"Junfeng","family":"Wang","sequence":"additional","affiliation":[{"name":"South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Chemical Biology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6550-9017","authenticated-orcid":false,"given":"Ming-Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Research Center for Deepsea Bioresources, Sanya 572025, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,13]]},"reference":[{"key":"ref_1","first-page":"740","article-title":"Recent advances in marine-derived bioactives towards cancer therapy","volume":"4","author":"Tamzi","year":"2024","journal-title":"Int. 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