{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:39:38Z","timestamp":1792427978637,"version":"4.5.0"},"reference-count":158,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Functional seafoods derived from marine organisms, including fish, shellfish and algae, are gaining increasing attention due to their high content of bioactive compounds, such as omega-3 fatty acids, peptides, polysaccharides and antioxidants, which provide health benefits beyond basic nutrition. These marine-derived compounds exhibit a wide range of biological activities and have been investigated for their potential roles in the prevention and management of chronic diseases, including cardiovascular, neurodegenerative, cancer and gastrointestinal disorders. Their effects are largely mediated through anti-inflammatory, antioxidant and immunomodulatory mechanisms. Advances in biotechnology, including genetic engineering and improved extraction of bioactive compounds, have enhanced the nutritional quality and pharmacological relevance of functional seafoods. At the same time, sustainable aquaculture practices are being developed to reduce environmental impacts. Nevertheless, challenges such as regulatory inconsistencies, scalability issues and limited understanding of bioavailability and long-term effects still persist. These constraints should be considered when interpreting mechanistic and efficacy findings presented across different study designs and exposure conditions. Future perspectives highlight innovations in precision aquaculture, waste valorisation and traceability as key strategies to improve sustainability and strengthen consumer trust. This review summarizes current knowledge on functional seafoods, with emphasis on pharmacological mechanisms, clinical applications and the need for interdisciplinary research to optimize their health benefits and commercial potential.<\/jats:p>","DOI":"10.3390\/md24030116","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T08:49:28Z","timestamp":1774255768000},"page":"116","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Marine Bioactive Compounds from Functional Seafoods: Pharmacological Mechanisms and Health Applications"],"prefix":"10.3390","volume":"24","author":[{"given":"Sena","family":"Davran Bulut","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Institute of Natural and Applied Sciences, \u00c7ukurova University, Balcal\u0131, 01330 Adana, T\u00fcrkiye"},{"name":"Department of Biotechnology, Faculty of Science, Bartin University, 74100 Bartin, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9386-091X","authenticated-orcid":false,"given":"Naciye","family":"Yaktubay D\u00f6nda\u015f","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Institute of Natural and Applied Sciences, \u00c7ukurova University, Balcal\u0131, 01330 Adana, T\u00fcrkiye"},{"name":"Department of Medical Pharmacology, Faculty of Medicine, \u00c7ukurova University, Balcal\u0131, 01330 Adana, T\u00fcrkiye"},{"name":"Department of Translational Medicine, Institute of Health Sciences, \u00c7ukurova University, Balcal\u0131, 01330 Adana, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Senanur","family":"Ko\u00e7han","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Institute of Natural and Applied Sciences, \u00c7ukurova University, Balcal\u0131, 01330 Adana, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beyza Nur","family":"Arslan","sequence":"additional","affiliation":[{"name":"Department of Medical Pharmacology, Faculty of Medicine, \u00c7ukurova University, Balcal\u0131, 01330 Adana, T\u00fcrkiye"},{"name":"Department of Basic Pharmaceutical Sciences, Faculty of Pharmacy, \u00c7ukurova University, Balcal\u0131, 01330 Adana, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet Ali","family":"Tamer","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Institute of Natural and Applied Sciences, \u00c7ukurova University, Balcal\u0131, 01330 Adana, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirsade","family":"Osmani","sequence":"additional","affiliation":[{"name":"Faculty of Food Technology, University of Mitrovica \u201cIsa Boletini\u201d, Str. Ukshin Kovacica, 40000 Mitrovica, Kosovo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5958-734X","authenticated-orcid":false,"given":"Safa","family":"Baraketi","sequence":"additional","affiliation":[{"name":"Laboratory of Natural Substances (LSN), National Institute of Research and Physicochemical Analysis (INRAP), BiotechPole Sidi Thabet, Sidi Thabet 2020, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9715-5866","authenticated-orcid":false,"given":"Khaoula","family":"Khwaldia","sequence":"additional","affiliation":[{"name":"Laboratory of Natural Substances (LSN), National Institute of Research and Physicochemical Analysis (INRAP), BiotechPole Sidi Thabet, Sidi Thabet 2020, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9881-3565","authenticated-orcid":false,"given":"Ziye","family":"Zhang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Marine Food Processing & Safety Control, College of Food Science and Engineering, Ocean University of China, Qingdao 266404, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4180-8423","authenticated-orcid":false,"given":"Hac\u0131 Ali","family":"D\u00f6nda\u015f","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Institute of Natural and Applied Sciences, \u00c7ukurova University, Balcal\u0131, 01330 Adana, T\u00fcrkiye"},{"name":"Department of Basic Pharmaceutical Sciences, Faculty of Pharmacy, \u00c7ukurova University, Balcal\u0131, 01330 Adana, T\u00fcrkiye"},{"name":"Department of Advanced Materials and Nanotechnology, Institute of Natural and Applied Sciences, \u00c7ukurova University, Balcal\u0131, 01330 Adana, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2413-6925","authenticated-orcid":false,"given":"Tuba","family":"Esatbeyoglu","sequence":"additional","affiliation":[{"name":"Department of Molecular Food Chemistry and Food Development, Institute of Food and One Health, Gottfried Wilhelm Leibniz University Hannover, Am Kleinen Felde 30, 30167 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6050-5922","authenticated-orcid":false,"given":"Panagiota","family":"Katikou","sequence":"additional","affiliation":[{"name":"Veterinary Research Institute of Thessaloniki, Hellenic Agricultural Organization\u2014DIMITRA, Ktima Thermis, 57001 Thessaloniki, Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0655-0105","authenticated-orcid":false,"given":"Fatih","family":"Ozogul","sequence":"additional","affiliation":[{"name":"Department of Seafood Processing Technology, Faculty of Fisheries, \u00c7ukurova University, Balcal\u0131, 01330 Adana, T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,3,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.foodres.2015.04.005","article-title":"Protein hydrolysates from animal processing by-products as a source of bioactive molecules with interest in animal feeding: A review","volume":"73","author":"Chamorro","year":"2015","journal-title":"Food Res. 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