{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T13:09:16Z","timestamp":1776863356290,"version":"3.51.2"},"reference-count":28,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T00:00:00Z","timestamp":1776816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Natural Science Foundation of Guangxi","award":["2026GXNSFBA00640037"],"award-info":[{"award-number":["2026GXNSFBA00640037"]}]},{"name":"Guangxi Key Research and Development Programme","award":["AB24010109"],"award-info":[{"award-number":["AB24010109"]}]},{"name":"Middle-Aged Teachers Scientific Research Project of Guangxi Universities","award":["2025KY0396"],"award-info":[{"award-number":["2025KY0396"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Three new, previously undescribed tanzawaic acids, steckwaic acids H\u2013J (1\u20133), and twenty-three known natural products (4\u201326) were isolated from the marine algicolous fungus Penicillium steckii SCSIO 41040. Structurally, compound 3 underwent a rare hydration reaction at the double bond of its carboxylic acid side chain. The chemical structures and stereochemistry were determined using comprehensive spectroscopic analyses, including NMR, electronic circular dichroism (ECD) calculations, and high-resolution electrospray ionization mass spectrometry (HRESIMS), and verified by literature comparison. The protective effect of tanzawaic acids on inflammatory damage to the intestinal epithelial barrier was assessed using an LPS-stimulated Caco-2\/THP-1 co-culture model. Notably, immunofluorescence and Western blotting assays showed that compound 10 significantly enhanced the fluorescence signals and protein expression of ZO-1 and occludin, alleviated lipopolysaccharide (LPS)-induced intestinal barrier damage in Caco-2 cells, and contributed to the re-establishment of intestinal barrier homeostasis. Our findings demonstrate the critical role of tanzawaic acids in maintaining intestinal barrier integrity, identifying them as promising lead compounds for UC treatment.<\/jats:p>","DOI":"10.3390\/md24050147","type":"journal-article","created":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T12:00:32Z","timestamp":1776859232000},"page":"147","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anti-Ulcerative Colitis Tanzawaic Acids from a Marine Algicolous Fungus, Penicillium steckii SCSIO 41040"],"prefix":"10.3390","volume":"24","author":[{"given":"Yingying","family":"Song","sequence":"first","affiliation":[{"name":"Institute of Marine Drugs, Faculty of Pharmacy, Guangxi Key Laboratory of Marine Drugs, University Engineering Research Center of High-Efficient Utilization of Marine Traditional Chinese Medicine Resources, Guangxi, Guangxi University of Chinese Medicine, Nanning 530200, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiamin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou 510632, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuchen","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, School of Medicine, Jinan University, Guangzhou 510632, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianglian","family":"She","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Marine Materia Medica\/State Key Laboratory of Tropical Oceanography, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China"},{"name":"University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yalin","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Marine Drugs, Faculty of Pharmacy, Guangxi Key Laboratory of Marine Drugs, University Engineering Research Center of High-Efficient Utilization of Marine Traditional Chinese Medicine Resources, Guangxi, Guangxi University of Chinese Medicine, Nanning 530200, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangxi","family":"Yi","sequence":"additional","affiliation":[{"name":"Institute of Marine Drugs, Faculty of Pharmacy, Guangxi Key Laboratory of Marine Drugs, University Engineering Research Center of High-Efficient Utilization of Marine Traditional Chinese Medicine Resources, Guangxi, Guangxi University of Chinese Medicine, Nanning 530200, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7524-8049","authenticated-orcid":false,"given":"Chenghai","family":"Gao","sequence":"additional","affiliation":[{"name":"Institute of Marine Drugs, Faculty of Pharmacy, Guangxi Key Laboratory of Marine Drugs, University Engineering Research Center of High-Efficient Utilization of Marine Traditional Chinese Medicine Resources, Guangxi, Guangxi University of Chinese Medicine, Nanning 530200, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6702-5366","authenticated-orcid":false,"given":"Junfeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Guangdong Key Laboratory of Marine Materia Medica\/State Key Laboratory of Tropical Oceanography, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China"},{"name":"University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8327-3108","authenticated-orcid":false,"given":"Yonghong","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Marine Drugs, Faculty of Pharmacy, Guangxi Key Laboratory of Marine Drugs, University Engineering Research Center of High-Efficient Utilization of Marine Traditional Chinese Medicine Resources, Guangxi, Guangxi University of Chinese Medicine, Nanning 530200, China"},{"name":"Guangdong Key Laboratory of Marine Materia Medica\/State Key Laboratory of Tropical Oceanography, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China"},{"name":"University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1021\/acs.jnatprod.1c01020","article-title":"Tanzawaic Acids from a Deep-Sea Derived Penicillium Species","volume":"85","author":"Wang","year":"2022","journal-title":"J. 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