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This review establishes DT as a model Smart Secondary Metabolite based on the convergence of a unique molecular architecture of rigid stereogroups connected by flexible bonds; a high metabolic yield (0.42% w\/w of crude extract); potent selective bioactivity against kinetoplastids and drug-resistant tumors; multi-target modulation of protein phosphatase 2A (PP2A) and cell-surface integrins; and distinctive chemotaxonomic relevance within Macaronesian communities. Its biosynthesis proceeds through stereocontrolled epoxide-opening cascades, generating an evolutionarily refined scaffold. Ecologically, DT operates as a multifunctional shield, providing antifouling protection and deterring herbivory. Pharmacologically, it acts as a selective signaling modulator, triggering integrin-mediated cell death (IMD) in resistant cancer cells and inducing mitochondrial collapse in protozoa. In vivo studies in murine models of cutaneous leishmaniasis have demonstrated an 87% reduction in lesion size, reinforcing its promise as a lead structure.<\/jats:p>","DOI":"10.3390\/md24050155","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T07:49:36Z","timestamp":1777362576000},"page":"155","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Smart Secondary Metabolites in Marine Environments: Exploring the Oxasqualenoid Dehydrothyrsiferol"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8506-2435","authenticated-orcid":false,"given":"Francisco","family":"Cen-Pacheco","sequence":"first","affiliation":[{"name":"Facultad de Bioan\u00e1lisis, Campus-Veracruz, Universidad Veracruzana, Veracruz 91700, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8886-7519","authenticated-orcid":false,"given":"Ana R.","family":"D\u00edaz-Marrero","sequence":"additional","affiliation":[{"name":"Instituto de Productos Naturales y Agrobiolog\u00eda (IPNA), Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Avenida Astrof\u00edsico Francisco S\u00e1nchez 3, 38206 La Laguna, Spain"},{"name":"Biotecnolog\u00eda Marina, IUBO-ULL, Unidad Asociada al IPNA-CSIC, 38206 La Laguna, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0805-8317","authenticated-orcid":false,"given":"Jos\u00e9 J.","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Biotecnolog\u00eda Marina, IUBO-ULL, Unidad Asociada al IPNA-CSIC, 38206 La Laguna, Spain"},{"name":"Instituto Universitario de Bio-Org\u00e1nica Antonio Gonz\u00e1lez (IUBO AG), Universidad de La Laguna (ULL), Avenida Astrof\u00edsico Francisco S\u00e1nchez 2, 38206 La Laguna, Spain"},{"name":"Departamento de Qu\u00edmica Org\u00e1nica, Universidad de La Laguna (ULL), Avenida Astrof\u00edsico Francisco S\u00e1nchez 3, 38206 La Laguna, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural Products as Sources of New Drugs Over the Nearly Four Decades from 01\/1981 to 09\/2019","volume":"83","author":"Newman","year":"2020","journal-title":"J. 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