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Marine natural products with inherent neuroactive properties exhibit unparalleled intervention advantages for targeting this complex pathophysiological axis. Herein, we systematically and prospectively dissect the multi-layered bidirectional communication between the nervous system and malignancies, comprehensively summarize the pivotal contributions of marine-derived bioactive molecules to advances in neuroscience and antitumor therapeutics, and finally provide an outlook on and a call for integrated, interdisciplinary collaboration to enable transformative breakthroughs in the development of marine neuropharmacological agents targeting the nerve\u2013tumor crosstalk axis.<\/jats:p>","DOI":"10.3390\/md24060219","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T15:11:22Z","timestamp":1781709082000},"page":"219","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Potential and Prospects of Marine Drugs in Intervening Nerve\u2013Tumor Crosstalk"],"prefix":"10.3390","volume":"24","author":[{"given":"Dan","family":"Zhao","sequence":"first","affiliation":[{"name":"Basic Medicine Research and Innovation Center for Novel Target and Therapeutic Intervention, College of Pharmacy, Chongqing Medical University, Ministry of Education, Chongqing 400016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiling","family":"Xu","sequence":"additional","affiliation":[{"name":"The First Clinical College, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3527-890X","authenticated-orcid":false,"given":"Xinyan","family":"Xu","sequence":"additional","affiliation":[{"name":"The First Clinical College, Chongqing Medical University, Chongqing 400016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxuan","family":"Tan","sequence":"additional","affiliation":[{"name":"The First Clinical College, 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progression","volume":"341","author":"Magnon","year":"2013","journal-title":"Science"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.bbi.2015.12.014","article-title":"Sympathetic innervation, norepinephrine content, and norepinephrine turnover in orthotopic and spontaneous models of breast cancer","volume":"53","author":"Szpunar","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1158\/2159-8290.CD-25-1337","article-title":"Myofibroblasts Induce Neuroplasticity to Promote Pancreatic Inflammation and Cancer Progression","volume":"16","author":"Nigri","year":"2026","journal-title":"Cancer Discov."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1038\/s41392-025-02364-y","article-title":"Cancer neuroscience: Signaling pathways and new therapeutic strategies for cancer","volume":"11","author":"Zhang","year":"2026","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s13402-025-01151-9","article-title":"Neural-tumor crosstalk and molecular targeting: Mechanisms and therapeutic implications in cancer neuroscience","volume":"49","author":"Hou","year":"2026","journal-title":"Cell. Oncol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ccell.2016.11.005","article-title":"Nerve Growth Factor Promotes Gastric Tumorigenesis through Aberrant Cholinergic Signaling","volume":"31","author":"Hayakawa","year":"2017","journal-title":"Cancer Cell"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s10555-023-10095-1","article-title":"The tumor-nerve circuit in breast cancer","volume":"42","author":"Cui","year":"2023","journal-title":"Cancer Metastasis Rev."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1038\/s41586-025-10028-8","article-title":"Tumour-brain crosstalk restrains cancer immunity via a sensory-sympathetic axis","volume":"650","author":"Wei","year":"2026","journal-title":"Nature"},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Mardelle, U., Bretaud, N., Daher, C., and Feuillet, V. (2024). From pain to tumor immunity: Influence of peripheral sensory neurons in cancer. Front. Immunol., 15.","DOI":"10.3389\/fimmu.2024.1335387"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.trecan.2026.01.003","article-title":"Nociceptive neuroimmune circuit drives immune evasion","volume":"12","author":"Cao","year":"2026","journal-title":"Trends Cancer"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"116059","DOI":"10.1016\/j.celrep.2025.116059","article-title":"Neuroimmune axis in gastrointestinal cancers: From mechanisms to therapeutic breakthrough","volume":"44","author":"Zhang","year":"2025","journal-title":"Cell Rep."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1016\/j.neuron.2025.07.009","article-title":"Wired to spread: Neural regulation of metastasis","volume":"113","author":"Sloan","year":"2025","journal-title":"Neuron"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.1158\/0008-5472.CAN-18-3995","article-title":"Exosomal Induction of Tumor Innervation","volume":"79","author":"Vermeer","year":"2019","journal-title":"Cancer Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2736","DOI":"10.1158\/0008-5472.CAN-18-3872","article-title":"Melanoma-Induced Reprogramming of Schwann Cell Signaling Aids Tumor Growth","volume":"79","author":"Shurin","year":"2019","journal-title":"Cancer Res."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/s41586-019-1219-y","article-title":"Progenitors from the central nervous system drive neurogenesis in cancer","volume":"569","author":"Mauffrey","year":"2019","journal-title":"Nature"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/s41586-020-1996-3","article-title":"Loss of p53 drives neuron reprogramming in head and neck cancer","volume":"578","author":"Amit","year":"2020","journal-title":"Nature"},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Mu\u00f1oz, J.P., and Calaf, G.M. (2023). Acetylcholine, Another Factor in Breast Cancer. Biology, 12.","DOI":"10.3390\/biology12111418"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"338","DOI":"10.2174\/1570159X15666170912110450","article-title":"Neuronal and Extraneuronal Nicotinic Acetylcholine Receptors","volume":"16","author":"Zoli","year":"2018","journal-title":"Curr. Neuropharmacol."},{"key":"ref_21","first-page":"e70387","article-title":"Nicotinic Acetylcholine Receptor Pathways in Cancer: From Psychiatric Clues to Therapeutic Opportunities","volume":"8","author":"Azadi","year":"2025","journal-title":"Cancer Rep."},{"key":"ref_22","first-page":"159","article-title":"Cholinergic \u03b15 nicotinic receptor is involved in the proliferation and invasion of human prostate cancer cells","volume":"43","author":"Qi","year":"2020","journal-title":"Oncol. Rep."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1021\/acsptsci.3c00138","article-title":"Targeting Alpha7 Nicotinic Acetylcholine Receptors in Lung Cancer: Insights, Challenges, and Therapeutic Strategies","volume":"7","author":"Arunrungvichian","year":"2024","journal-title":"ACS Pharmacol. Transl. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1007\/s10456-024-09944-6","article-title":"The angiogenic role of the alpha 9-nicotinic acetylcholine receptor in triple-negative breast cancers","volume":"27","author":"Ochirbat","year":"2024","journal-title":"Angiogenesis"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"9650481","DOI":"10.1155\/2016\/9650481","article-title":"The Oncogenic Functions of Nicotinic Acetylcholine Receptors","volume":"2016","author":"Zhao","year":"2016","journal-title":"J. Oncol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/ijc.23894","article-title":"Nicotine induces cell proliferation, invasion and epithelial-mesenchymal transition in a variety of human cancer cell lines","volume":"124","author":"Dasgupta","year":"2009","journal-title":"Int. J. Cancer"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1038\/s41586-025-08591-1","article-title":"Nociceptive neurons promote gastric tumour progression via a CGRP-RAMP1 axis","volume":"640","author":"Zhi","year":"2025","journal-title":"Nature"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"116994","DOI":"10.1016\/j.celrep.2026.116994","article-title":"CGRP signaling links tumor-associated pain to immune evasion in oral squamous cell carcinoma","volume":"45","author":"McIlvried","year":"2026","journal-title":"Cell Rep."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"e000842","DOI":"10.1136\/bmjonc-2025-000842","article-title":"Sensory neuropeptide CGRP and its co-receptor RAMP1 drive tumour cell growth in gastrointestinal cancers","volume":"4","author":"Parathan","year":"2025","journal-title":"BMJ Oncol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1016\/j.trecan.2025.07.004","article-title":"CGRP-mediated neural addiction in tumor dynamic remodeling","volume":"11","author":"Xu","year":"2025","journal-title":"Trends Cancer"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Erin, N., and Szallasi, A. (2023). Carcinogenesis and Metastasis: Focus on TRPV1-Positive Neurons and Immune Cells. Biomolecules, 13.","DOI":"10.3390\/biom13060983"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"100330","DOI":"10.1016\/j.jbo.2020.100330","article-title":"The HMGB1\/RAGE axis induces bone pain associated with colonization of 4T1 mouse breast cancer in bone","volume":"26","author":"Okui","year":"2021","journal-title":"J. Bone Oncol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"4121","DOI":"10.1038\/s41598-022-08005-6","article-title":"Oral cancer induced TRPV1 sensitization is mediated by PAR(2) signaling in primary afferent neurons innervating the cancer microenvironment","volume":"12","author":"Scheff","year":"2022","journal-title":"Sci. Rep."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/2211-5463.12570","article-title":"Recurrent activations of transient receptor potential vanilloid-1 and vanilloid-4 promote cellular proliferation and migration in esophageal squamous cell carcinoma cells","volume":"9","author":"Huang","year":"2019","journal-title":"FEBS Open Bio"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"3636","DOI":"10.1038\/s41388-019-0684-y","article-title":"The P2X7 receptor modulates immune cells infiltration, ectonucleotidases expression and extracellular ATP levels in the tumor microenvironment","volume":"38","author":"Orioli","year":"2019","journal-title":"Oncogene"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/nature04515","article-title":"Cryopyrin activates the inflammasome in response to toxins and ATP","volume":"440","author":"Mariathasan","year":"2006","journal-title":"Nature"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"48972","DOI":"10.18632\/oncotarget.16903","article-title":"P2X7 receptor and NLRP3 inflammasome activation in head and neck cancer","volume":"8","author":"Bae","year":"2017","journal-title":"Oncotarget"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"e1135","DOI":"10.1038\/cddis.2014.109","article-title":"ATP\/P2X7 axis modulates myeloid-derived suppressor cell functions in neuroblastoma microenvironment","volume":"5","author":"Bianchi","year":"2014","journal-title":"Cell Death Dis."},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Lu, H.J., Wu, X.B., and Wei, Q.Q. (2023). Ion channels in cancer-induced bone pain: From molecular mechanisms to clinical applications. Front. Mol. Neurosci., 16.","DOI":"10.3389\/fnmol.2023.1239599"},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1523\/JNEUROSCI.0899-17.2017","article-title":"DRG Voltage-Gated Sodium Channel 1.7 Is Upregulated in Paclitaxel-Induced Neuropathy in Rats and in Humans with Neuropathic Pain","volume":"38","author":"Li","year":"2018","journal-title":"J. Neurosci."},{"key":"ref_41","doi-asserted-by":"crossref","unstructured":"Comes, N., Bielanska, J., Vallejo-Gracia, A., Serrano-Albarr\u00e1s, A., Marruecos, L., G\u00f3mez, D., Soler, C., Condom, E., Ram\u00f3n, Y.C.S., and Hern\u00e1ndez-Losa, J. (2013). The voltage-dependent K(+) channels Kv1.3 and Kv1.5 in human cancer. Front. Physiol., 4.","DOI":"10.3389\/fphys.2013.00283"},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1158\/0008-5472.CAN-15-3545","article-title":"Bone Pain Induced by Multiple Myeloma Is Reduced by Targeting V-ATPase and ASIC3","volume":"77","author":"Hiasa","year":"2017","journal-title":"Cancer Res."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/s41586-025-09370-8","article-title":"Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy","volume":"646","author":"Baruch","year":"2025","journal-title":"Nature"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"eads7889","DOI":"10.1126\/scisignal.ads7889","article-title":"Tumor-infiltrating nociceptor neurons promote immunosuppression","volume":"18","author":"Restaino","year":"2025","journal-title":"Sci. Signal"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1038\/s41420-021-00752-1","article-title":"Sympathetic signaling facilitates progression of neuroendocrine prostate cancer","volume":"7","author":"Dwivedi","year":"2021","journal-title":"Cell Death Discov."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41573-020-00114-z","article-title":"Natural products in drug discovery: Advances and opportunities","volume":"20","author":"Atanasov","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"D1670","DOI":"10.1093\/nar\/gkae973","article-title":"Generic Diagramming Platform (GDP): A comprehensive database of high-quality biomedical graphics","volume":"53","author":"Jiang","year":"2025","journal-title":"Nucleic Acids Res."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/0014-5793(94)80518-0","article-title":"Serotonin release and cell proliferation are under the control of alpha-bungarotoxin-sensitive nicotinic receptors in small-cell lung carcinoma cell lines","volume":"342","author":"Codignola","year":"1994","journal-title":"FEBS Lett."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0304-3940(96)12423-X","article-title":"alpha-Conotoxin imperialis I inhibits nicotine-evoked hormone release and cell proliferation in human neuroendocrine carcinoma cells","volume":"206","author":"Codignola","year":"1996","journal-title":"Neurosci. Lett."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"12742","DOI":"10.1038\/s41598-017-11586-2","article-title":"Effects of \u03b1-conotoxin ImI on TNF-\u03b1, IL-8 and TGF-\u03b2 expression by human macrophage-like cells derived from THP-1 pre-monocytic leukemic cells","volume":"7","author":"Padilla","year":"2017","journal-title":"Sci. Rep."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1111\/bph.13954","article-title":"\u03b19- and \u03b17-containing receptors mediate the pro-proliferative effects of nicotine in the A549 adenocarcinoma cell line","volume":"175","author":"Mucchietto","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Improgo, M.R., Soll, L.G., Tapper, A.R., and Gardner, P.D. (2013). Nicotinic acetylcholine receptors mediate lung cancer growth. Front. Physiol., 4.","DOI":"10.3389\/fphys.2013.00251"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"172674","DOI":"10.1016\/j.ejphar.2019.172674","article-title":"Identification of nicotinic acetylcholine receptor subunits in different lung cancer cell lines and the inhibitory effect of alpha-conotoxin TxID on lung cancer cell growth","volume":"865","author":"Qian","year":"2019","journal-title":"Eur. J. Pharmacol."},{"key":"ref_54","doi-asserted-by":"crossref","unstructured":"Liu, Y., Qian, J., Sun, Z., Zhangsun, D., and Luo, S. (2019). Cervical Cancer Correlates with the Differential Expression of Nicotinic Acetylcholine Receptors and Reveals Therapeutic Targets. Mar. Drugs, 17.","DOI":"10.3390\/md17050256"},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Sun, Z., Zhangsun, M., Dong, S., Liu, Y., Qian, J., Zhangsun, D., and Luo, S. (2020). Differential Expression of Nicotine Acetylcholine Receptors Associates with Human Breast Cancer and Mediates Antitumor Activity of \u03b1O-Conotoxin GeXIVA. Mar. Drugs, 18.","DOI":"10.3390\/md18010061"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Sun, Z., Bao, J., Zhangsun, M., Dong, S., Zhangsun, D., and Luo, S. (2020). \u03b1O-Conotoxin GeXIVA Inhibits the Growth of Breast Cancer Cells via Interaction with \u03b19 Nicotine Acetylcholine Receptors. Mar. Drugs, 18.","DOI":"10.3390\/md18040195"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Guo, X., He, L., Xu, W., Wang, W., Feng, X., Fu, Y., Zhang, X., Ding, R.B., Qi, X., and Bao, J. (2024). \u03b1O-Conotoxin GeXIVA[1,2] Suppresses In Vivo Tumor Growth of Triple-Negative Breast Cancer by Inhibiting AKT-mTOR, STAT3 and NF-\u03baB Signaling Mediated Proliferation and Inducing Apoptosis. Mar. Drugs, 22.","DOI":"10.3390\/md22060252"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Oroz-Parra, I., Navarro, M., Cervantes-Luevano, K.E., \u00c1lvarez-Delgado, C., Salvesen, G., Sanchez-Campos, L.N., and Licea-Navarro, A.F. (2016). Apoptosis Activation in Human Lung Cancer Cell Lines by a Novel Synthetic Peptide Derived from Conus californicus Venom. Toxins, 8.","DOI":"10.3390\/toxins8020038"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Oroz-Parra, I., \u00c1lvarez-Delgado, C., Cervantes-Luevano, K., Due\u00f1as-Espinoza, S., and Licea-Navarro, A.F. (2019). Proapoptotic Index Evaluation of Two Synthetic Peptides Derived from the Coneshell Californiconus californicus in Lung Cancer Cell Line H1299. Mar. Drugs, 18.","DOI":"10.3390\/md18010010"},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1074\/jbc.M114.605592","article-title":"Alanine scan of \u03b1-conotoxin RegIIA reveals a selective \u03b13\u03b24 nicotinic acetylcholine receptor antagonist","volume":"290","author":"Kompella","year":"2015","journal-title":"J. Biol. Chem."},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Kasheverov, I.E., Logashina, Y.A., Kornilov, F.D., Lushpa, V.A., Maleeva, E.E., Korolkova, Y.V., Yu, J., Zhu, X., Zhangsun, D., and Luo, S. (2022). Peptides from the Sea Anemone Metridium senile with Modified Inhibitor Cystine Knot (ICK) Fold Inhibit Nicotinic Acetylcholine Receptors. Toxins, 15.","DOI":"10.3390\/toxins15010028"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"10499","DOI":"10.1021\/ja201254c","article-title":"Total synthesis of pinnatoxins A and G and revision of the mode of action of pinnatoxin A","volume":"133","author":"Araoz","year":"2011","journal-title":"J. Am. Chem. Soc."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/jnc.13245","article-title":"Pinnatoxins E, F and G target multiple nicotinic receptor subtypes","volume":"135","author":"Hellyer","year":"2015","journal-title":"J. Neurochem."},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1021\/acs.jnatprod.1c00418","article-title":"Cyclic Imine Pinnatoxin G is Cytotoxic to Cancer Cell Lines via Nicotinic Acetylcholine Receptor-Driven Classical Apoptosis","volume":"84","author":"Clarke","year":"2021","journal-title":"J. Nat. Prod."},{"key":"ref_65","first-page":"1381","article-title":"Marine sponge-derived polymeric alkylpyridinium salts as a novel tumor chemotherapeutic targeting the cholinergic system in lung tumors","volume":"29","author":"Paleari","year":"2006","journal-title":"Int. J. Oncol."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"2574","DOI":"10.3390\/md11072574","article-title":"APS8, a polymeric alkylpyridinium salt blocks \u03b17 nAChR and induces apoptosis in non-small cell lung carcinoma","volume":"11","author":"Zovko","year":"2013","journal-title":"Mar. Drugs"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Berne, S., \u010cema\u017ear, M., Frange\u017e, R., Juntes, P., Kranjc, S., Grandi\u010d, M., Savarin, M., and Turk, T. (2018). APS8 Delays Tumor Growth in Mice by Inducing Apoptosis of Lung Adenocarcinoma Cells Expressing High Number of \u03b17 Nicotinic Receptors. Mar. Drugs, 16.","DOI":"10.3390\/md16100367"},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"117007","DOI":"10.1016\/j.biopha.2024.117007","article-title":"Gelatin nanoparticles loaded with 3-alkylpyridinium salt APS7, an analog of marine toxin, are a promising support in human lung cancer therapy","volume":"177","author":"Kononenko","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.3390\/md12041859","article-title":"Marine natural products acting on the acetylcholine-binding protein and nicotinic receptors: From computer modeling to binding studies and electrophysiology","volume":"12","author":"Kudryavtsev","year":"2014","journal-title":"Mar. Drugs"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"69703","DOI":"10.18632\/oncotarget.11941","article-title":"Marine compound rhizochalinin shows high in vitro and in vivo efficacy in castration resistant prostate cancer","volume":"7","author":"Dyshlovoy","year":"2016","journal-title":"Oncotarget"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s42269-022-00704-4","article-title":"In silico prediction and structure-based multitargeted molecular docking analysis of selected bioactive compounds against mucormycosis","volume":"46","author":"Madanagopal","year":"2022","journal-title":"Bull. Natl. Res. Cent."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.5530\/pj.2021.13.221","article-title":"In silico Study on the Promising Active Components of Terpenoid and Fucoidon from Sargassum sp. in Inhibiting CGRP and TNF-\u03b1","volume":"13","author":"Adam","year":"2021","journal-title":"Pharmacogn. J."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"23914","DOI":"10.1074\/jbc.M800776200","article-title":"Analgesic compound from sea anemone Heteractis crispa is the first polypeptide inhibitor of vanilloid receptor 1 (TRPV1)","volume":"283","author":"Andreev","year":"2008","journal-title":"J. Biol. Chem."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"5100","DOI":"10.3390\/md11125100","article-title":"Polypeptide modulators of TRPV1 produce analgesia without hyperthermia","volume":"11","author":"Andreev","year":"2013","journal-title":"Mar. Drugs"},{"key":"ref_75","doi-asserted-by":"crossref","unstructured":"Monastyrnaya, M., Peigneur, S., Zelepuga, E., Sintsova, O., Gladkikh, I., Leychenko, E., Isaeva, M., Tytgat, J., and Kozlovskaya, E. (2016). Kunitz-Type Peptide HCRG21 from the Sea Anemone Heteractis crispa Is a Full Antagonist of the TRPV1 Receptor. Mar. Drugs, 14.","DOI":"10.3390\/md14120229"},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"3746","DOI":"10.1021\/jm101621u","article-title":"Nobilamides A-H, long-acting transient receptor potential vanilloid-1 (TRPV1) antagonists from mollusk-associated bacteria","volume":"54","author":"Lin","year":"2011","journal-title":"J. Med. Chem."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Korolkova, Y., Makarieva, T., Tabakmakher, K., Shubina, L., Kudryashova, E., Andreev, Y., Mosharova, I., Lee, H.S., Lee, Y.J., and Kozlov, S. (2017). Marine Cyclic Guanidine Alkaloids Monanchomycalin B and Urupocidin A Act as Inhibitors of TRPV1, TRPV2 and TRPV3, but not TRPA1 Receptors. Mar. Drugs, 15.","DOI":"10.3390\/md15040087"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"127136","DOI":"10.1016\/j.ijbiomac.2023.127136","article-title":"Novel marine natural products as effective TRPV1 channel blockers","volume":"253","author":"Ye","year":"2023","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_79","doi-asserted-by":"crossref","unstructured":"Dutot, M., Olivier, E., Fouyet, S., Magny, R., Hammad, K., Roulland, E., Rat, P., and Fagon, R. (2021). In Vitro Chemopreventive Potential of Phlorotannins-Rich Extract from Brown Algae by Inhibition of Benzo[a]pyrene-Induced P2X7 Activation and Toxic Effects. Mar. Drugs, 19.","DOI":"10.3390\/md19010034"},{"key":"ref_80","doi-asserted-by":"crossref","unstructured":"Pislyagin, E.A., Menchinskaya, E.S., Gladkikh, I.N., Kvetkina, A.N., Sintsova, O.V., Popkova, D.V., Kozlovskiy, S.A., Gorpenchenko, T.Y., Likhatskaya, G.N., and Kaluzhskiy, L.A. (2023). Recombinant Analogs of Sea Anemone Kunitz-Type Peptides Influence P2X7 Receptor Activity in Neuro-2a Cells. Mar. Drugs, 21.","DOI":"10.3390\/md21030192"},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1021\/acs.jnatprod.5c00978","article-title":"Discovery of Na(v)1.7 Inhibitors through the Screening of Marine Natural Product Extracts","volume":"88","author":"Adewole","year":"2025","journal-title":"J. Nat. Prod."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"4213","DOI":"10.3390\/md11114213","article-title":"Evidence of accelerated evolution and ectodermal-specific expression of presumptive BDS toxin cDNAs from Anemonia viridis","volume":"11","author":"Nicosia","year":"2013","journal-title":"Mar. Drugs"},{"key":"ref_83","doi-asserted-by":"crossref","unstructured":"Mattei, C. (2018). Tetrodotoxin, a Candidate Drug for Nav1.1-Induced Mechanical Pain?. Mar. Drugs, 16.","DOI":"10.3390\/md16020072"},{"key":"ref_84","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez-Cano, R., Tejada, M., Artacho-Cord\u00f3n, A., Nieto, F.R., Entrena, J.M., Wood, J.N., and Cend\u00e1n, C.M. (2017). Effects of Tetrodotoxin in Mouse Models of Visceral Pain. Mar. Drugs, 15.","DOI":"10.3390\/md15060188"},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"100009","DOI":"10.1016\/j.pharmr.2024.100009","article-title":"Drugs from the ocean floor","volume":"77","author":"Khachab","year":"2025","journal-title":"Pharmacol. Rev."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1016\/j.clinthera.2009.11.017","article-title":"Current and emerging therapies for acute myeloid leukemia","volume":"31","author":"Robak","year":"2009","journal-title":"Clin. Ther."},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"4188","DOI":"10.1200\/JCO.2008.21.0088","article-title":"Efficacy and safety of trabectedin in patients with advanced or metastatic liposarcoma or leiomyosarcoma after failure of prior anthracyclines and ifosfamide: Results of a randomized phase II study of two different schedules","volume":"27","author":"Demetri","year":"2009","journal-title":"J. Clin. Oncol."},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S1470-2045(20)30068-1","article-title":"Lurbinectedin as second-line treatment for patients with small-cell lung cancer: A single-arm, open-label, phase 2 basket trial","volume":"21","author":"Trigo","year":"2020","journal-title":"Lancet Oncol."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/S0140-6736(11)60070-6","article-title":"Eribulin monotherapy versus treatment of physician\u2019s choice in patients with metastatic breast cancer (EMBRACE): A phase 3 open-label randomised study","volume":"377","author":"Cortes","year":"2011","journal-title":"Lancet"},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1200\/JCO.2010.29.9024","article-title":"Pralatrexate in patients with relapsed or refractory peripheral T-cell lymphoma: Results from the pivotal PROPEL study","volume":"29","author":"Pro","year":"2011","journal-title":"J. Clin. Oncol."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1056\/NEJM200012143432402","article-title":"Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia","volume":"343","author":"Rai","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1056\/NEJM199403103301007","article-title":"Newer purine analogues for the treatment of hairy-cell leukemia","volume":"330","author":"Saven","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1056\/NEJM197708112970601","article-title":"Adenine arabinoside therapy of biopsy-proved herpes simplex encephalitis. National Institute of Allergy and Infectious Diseases collaborative antiviral study","volume":"297","author":"Whitley","year":"1977","journal-title":"N. Engl. J. Med."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1001\/jama.291.1.63","article-title":"Intrathecal ziconotide in the treatment of refractory pain in patients with cancer or AIDS: A randomized controlled trial","volume":"291","author":"Staats","year":"2004","journal-title":"Jama"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1056\/NEJMoa1812792","article-title":"Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia","volume":"380","author":"Bhatt","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"ref_96","doi-asserted-by":"crossref","first-page":"5216","DOI":"10.1158\/0008-5472.CAN-07-5725","article-title":"Aplidin, a marine organism-derived compound with potent antimyeloma activity in vitro and in vivo","volume":"68","author":"Mitsiades","year":"2008","journal-title":"Cancer Res."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1093\/neuonc\/noae053","article-title":"Marizomib for patients with newly diagnosed glioblastoma: A randomized phase 3 trial","volume":"26","author":"Roth","year":"2024","journal-title":"Neuro Oncol."},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S2213-2600(24)00178-4","article-title":"Plinabulin plus docetaxel versus docetaxel in patients with non-small-cell lung cancer after disease progression on platinum-based regimen (DUBLIN-3): A phase 3, international, multicentre, single-blind, parallel group, randomised controlled trial","volume":"12","author":"Han","year":"2024","journal-title":"Lancet Respir. Med."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.1038\/sj.onc.1205410","article-title":"Squalamine and cisplatin block angiogenesis and growth of human ovarian cancer cells with or without HER-2 gene overexpression","volume":"21","author":"Li","year":"2002","journal-title":"Oncogene"},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1016\/S0959-8049(01)00275-1","article-title":"E7070, a novel sulphonamide agent with potent antitumour activity in vitro and in vivo","volume":"37","author":"Ozawa","year":"2001","journal-title":"Eur. J. Cancer"},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1038\/sj.bjc.6601321","article-title":"A multicentre phase II trial of bryostatin-1 in patients with advanced renal cancer","volume":"89","author":"Madhusudan","year":"2003","journal-title":"Br. J. Cancer"},{"key":"ref_102","doi-asserted-by":"crossref","first-page":"1430","DOI":"10.1158\/1535-7163.MCT-08-1167","article-title":"Phase I safety, pharmacokinetic, and pharmacogenomic trial of ES-285, a novel marine cytotoxic agent, administered to adult patients with advanced solid tumors","volume":"8","author":"Baird","year":"2009","journal-title":"Mol. Cancer Ther."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.jpainsymman.2011.05.003","article-title":"A spicamycin derivative (KRN5500) provides neuropathic pain relief in patients with advanced cancer: A placebo-controlled, proof-of-concept trial","volume":"43","author":"Weinstein","year":"2012","journal-title":"J. Pain Symptom Manag."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1111\/j.1349-7006.1997.tb00383.x","article-title":"Antitumor activity of TZT-1027, a novel dolastatin 10 derivative","volume":"88","author":"Kobayashi","year":"1997","journal-title":"Jpn. J. Cancer Res."},{"key":"ref_105","doi-asserted-by":"crossref","first-page":"114993","DOI":"10.1016\/j.carbpol.2019.114993","article-title":"A \u03b2-1,3\/1,6-glucan from Durvillaea Antarctica inhibits tumor progression in vivo as an immune stimulator","volume":"222","author":"Su","year":"2019","journal-title":"Carbohydr. Polym."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"17964","DOI":"10.1021\/acs.jmedchem.4c01566","article-title":"3-Deazaneplanocin A (DZNep): A Drug That Deserves a Second Look","volume":"67","author":"Marquez","year":"2024","journal-title":"J. Med. Chem."},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/CJI.0000000000000029","article-title":"A Phase I\/Ib study of folate immune (EC90 vaccine administered with GPI-0100 adjuvant followed by EC17) with interferon-\u03b1 and interleukin-2 in patients with renal cell carcinoma","volume":"37","author":"Amato","year":"2014","journal-title":"J. Immunother."},{"key":"ref_108","doi-asserted-by":"crossref","unstructured":"Davran Bulut, S., Yaktubay D\u00f6nda\u015f, N., Ko\u00e7han, S., Arslan, B.N., Tamer, M.A., Osmani, M., Baraketi, S., Khwaldia, K., Zhang, Z., and D\u00f6nda\u015f, H.A. (2026). Marine Bioactive Compounds from Functional Seafoods: Pharmacological Mechanisms and Health Applications. Mar. Drugs, 24.","DOI":"10.3390\/md24030116"},{"key":"ref_109","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2174\/1570159X14666160210142056","article-title":"Ziconotide Monotherapy: A Systematic Review of Randomised Controlled Trials","volume":"15","author":"Brookes","year":"2017","journal-title":"Curr. Neuropharmacol."},{"key":"ref_110","first-page":"825","article-title":"The Diagnosis and Treatment of Neuropathic Pain","volume":"121","author":"Ahmadi","year":"2024","journal-title":"Dtsch. Arztebl. Int."},{"key":"ref_111","first-page":"e1363","article-title":"Efficacy and safety of the Ca(v)2.2 blocker Ziconotide in pain: A meta-analysis and systematic review","volume":"10","author":"Castellanos","year":"2025","journal-title":"Pain Rep."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1525-1403.2006.00055.x","article-title":"Intrathecal ziconotide in the treatment of chronic nonmalignant pain: A randomized, double-blind, placebo-controlled clinical trial","volume":"9","author":"Wallace","year":"2006","journal-title":"Neuromodulation"},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1038\/sj.emboj.7600177","article-title":"A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid-sensitive channel in sensory neurons","volume":"23","author":"Diochot","year":"2004","journal-title":"Embo J."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"6059","DOI":"10.1523\/JNEUROSCI.5266-10.2011","article-title":"Acid-sensing ion channels in postoperative pain","volume":"31","author":"Deval","year":"2011","journal-title":"J. Neurosci."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"13124","DOI":"10.1073\/pnas.1120350109","article-title":"Human ASIC3 channel dynamically adapts its activity to sense the extracellular pH in both acidic and alkaline directions","volume":"109","author":"Delaunay","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1111\/j.1476-5381.2011.01674.x","article-title":"Inhibition of voltage-gated Na(+) currents in sensory neurones by the sea anemone toxin APETx2","volume":"165","author":"Blanchard","year":"2012","journal-title":"Br. J. Pharmacol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"9195","DOI":"10.1021\/jm501400p","article-title":"Understanding the molecular basis of toxin promiscuity: The analgesic sea anemone peptide APETx2 interacts with acid-sensing ion channel 3 and hERG channels via overlapping pharmacophores","volume":"57","author":"Jensen","year":"2014","journal-title":"J. Med. Chem."},{"key":"ref_118","doi-asserted-by":"crossref","unstructured":"Verkest, C., Salinas, M., Diochot, S., Deval, E., Lingueglia, E., and Baron, A. (2022). Mechanisms of Action of the Peptide Toxins Targeting Human and Rodent Acid-Sensing Ion Channels and Relevance to Their In Vivo Analgesic Effects. Toxins, 14.","DOI":"10.3390\/toxins14100709"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1111\/j.1476-5381.2010.00918.x","article-title":"Reversal of acid-induced and inflammatory pain by the selective ASIC3 inhibitor, APETx2","volume":"161","author":"Karczewski","year":"2010","journal-title":"Br. J. Pharmacol."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1111\/head.12152","article-title":"pH-evoked dural afferent signaling is mediated by ASIC3 and is sensitized by mast cell mediators","volume":"53","author":"Yan","year":"2013","journal-title":"Headache"},{"key":"ref_121","doi-asserted-by":"crossref","unstructured":"Gonz\u00e1lez-Cano, R., Ruiz-Cantero, M.C., Santos-Caballero, M., G\u00f3mez-Navas, C., Tejada, M., and Nieto, F.R. (2021). Tetrodotoxin, a Potential Drug for Neuropathic and Cancer Pain Relief?. Toxins, 13.","DOI":"10.3390\/toxins13070483"},{"key":"ref_122","doi-asserted-by":"crossref","unstructured":"Bucciarelli, G.M., Lechner, M., Fontes, A., Kats, L.B., Eisthen, H.L., and Shaffer, H.B. (2021). From Poison to Promise: The Evolution of Tetrodotoxin and Its Potential as a Therapeutic. Toxins, 13.","DOI":"10.3390\/toxins13080517"},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1124\/pr.57.4.4","article-title":"International Union of Pharmacology. XLVII. Nomenclature and structure-function relationships of voltage-gated sodium channels","volume":"57","author":"Catterall","year":"2005","journal-title":"Pharmacol. Rev."},{"key":"ref_124","doi-asserted-by":"crossref","unstructured":"Huerta, M., de la Nava, J., Artacho-Cord\u00f3n, A., and Nieto, F.R. (2023). Efficacy and Security of Tetrodotoxin in the Treatment of Cancer-Related Pain: Systematic Review and Meta-Analysis. Mar. Drugs, 21.","DOI":"10.3390\/md21050316"},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.pain.2007.10.012","article-title":"Tetrodotoxin inhibits the development and expression of neuropathic pain induced by paclitaxel in mice","volume":"137","author":"Nieto","year":"2008","journal-title":"Pain"},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/j.neuroscience.2015.10.059","article-title":"Antihyperalgesic effect of tetrodotoxin in rat models of persistent muscle pain","volume":"311","author":"Alvarez","year":"2015","journal-title":"Neuroscience"},{"key":"ref_127","doi-asserted-by":"crossref","unstructured":"Kavoosi, M., O\u2019Reilly, T.E., Kavoosi, M., Chai, P., Engel, C., Korz, W., Gallen, C.C., and Lester, R.M. (2020). Safety, Tolerability, Pharmacokinetics, and Concentration-QTc Analysis of Tetrodotoxin: A Randomized, Dose Escalation Study in Healthy Adults. Toxins, 12.","DOI":"10.3390\/toxins12080511"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"iv166","DOI":"10.1093\/annonc\/mdy152","article-title":"Management of cancer pain in adult patients: ESMO Clinical Practice Guidelines","volume":"29","author":"Fallon","year":"2018","journal-title":"Ann. Oncol."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1093\/annonc\/mdm056","article-title":"Prevalence of pain in patients with cancer: A systematic review of the past 40 years","volume":"18","author":"Kessels","year":"2007","journal-title":"Ann. Oncol."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1007\/s11864-024-01248-7","article-title":"Neuropathic Pain in Cancer: What Are the Current Guidelines?","volume":"25","author":"Mulvey","year":"2024","journal-title":"Curr. Treat. Options Oncol."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"8826","DOI":"10.3390\/curroncol30100637","article-title":"Predictors and Consequences of Cancer and Non-Cancer-Related Pain in Those Diagnosed with Primary and Metastatic Cancers","volume":"30","author":"Shah","year":"2023","journal-title":"Curr. Oncol."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1111\/j.1476-5381.2011.01335.x","article-title":"Analysis of opioid efficacy, tolerance, addiction and dependence from cell culture to human","volume":"164","author":"Morgan","year":"2011","journal-title":"Br. J. Pharmacol."},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"iv45","DOI":"10.1093\/neuonc\/nos203","article-title":"Peripheral neuropathies from chemotherapeutics and targeted agents: Diagnosis, treatment, and prevention","volume":"14","author":"Grisold","year":"2012","journal-title":"Neuro Oncol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"S54","DOI":"10.1016\/j.pain.2013.07.044","article-title":"Bone cancer pain: Causes, consequences, and therapeutic opportunities","volume":"154","author":"Mantyh","year":"2013","journal-title":"Pain"},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1146\/annurev-neuro-060909-153234","article-title":"Sodium channels in normal and pathological pain","volume":"33","author":"Cummins","year":"2010","journal-title":"Annu. Rev. Neurosci."},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"7212713","DOI":"10.1155\/2017\/7212713","article-title":"Tetrodotoxin for Moderate to Severe Cancer-Related Pain: A Multicentre, Randomized, Double-Blind, Placebo-Controlled, Parallel-Design Trial","volume":"2017","author":"Hagen","year":"2017","journal-title":"Pain Res. Manag."},{"key":"ref_137","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nrc.2017.77","article-title":"Tumour acidosis: From the passenger to the driver\u2019s seat","volume":"17","author":"Corbet","year":"2017","journal-title":"Nat. Rev. Cancer"},{"key":"ref_138","first-page":"693","article-title":"Acid-sensing ion channels: A new target for pain and CNS diseases","volume":"12","author":"Sluka","year":"2009","journal-title":"Curr. Opin. Drug Discov. Dev."},{"key":"ref_139","doi-asserted-by":"crossref","unstructured":"Wang, H., Li, X., Qiao, Y., Wang, M., Wang, W., McIntosh, J.M., Zhangsun, D., and Luo, S. (2024). \u03b1O-Conotoxin GeXIVA[1,2] Reduced Neuropathic Pain and Changed Gene Expression in Chronic Oxaliplatin-Induced Neuropathy Mice Model. Mar. Drugs, 22.","DOI":"10.3390\/md22010049"},{"key":"ref_140","doi-asserted-by":"crossref","unstructured":"Yu, R., Craik, D.J., and Kaas, Q. (2011). Blockade of neuronal \u03b17-nAChR by \u03b1-conotoxin ImI explained by computational scanning and energy calculations. PLoS Comput. Biol., 7.","DOI":"10.1371\/journal.pcbi.1002011"},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.biomaterials.2014.11.044","article-title":"The use of \u03b1-conotoxin ImI to actualize the targeted delivery of paclitaxel micelles to \u03b17 nAChR-overexpressing breast cancer","volume":"42","author":"Mei","year":"2015","journal-title":"Biomaterials"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1080\/10717544.2018.1436097","article-title":"\u03b1-Conotoxin ImI-modified polymeric micelles as potential nanocarriers for targeted docetaxel delivery to \u03b17-nAChR overexpressed non-small cell lung cancer","volume":"25","author":"Mei","year":"2018","journal-title":"Drug Deliv."},{"key":"ref_143","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s41392-024-01761-z","article-title":"Alpha5 nicotine acetylcholine receptor subunit promotes intrahepatic cholangiocarcinoma metastasis","volume":"9","author":"Fu","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1158\/1078-0432.CCR-10-2434","article-title":"Nicotinic acetylcholine receptor-based blockade: Applications of molecular targets for cancer therapy","volume":"17","author":"Wu","year":"2011","journal-title":"Clin. Cancer Res."},{"key":"ref_145","doi-asserted-by":"crossref","unstructured":"Cangini, M., Dall\u2019Ara, S., Rubini, S., Bertasi, B., Rizzi, P., Dell\u2019Orfano, G., Milandri, S., Manfredini, S., Baldini, E., and Vertuani, S. (2024). First Report of Pinnatoxin-G (PnTX-G) in a Marine-Coastal Area of the Adriatic Sea Associated with the Presence of the Dinoflagellate Vulcanodinium rugosum. Mar. Drugs, 22.","DOI":"10.3390\/md22030122"},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"31930","DOI":"10.1021\/acs.jafc.5c09429","article-title":"Fucoidan Alleviates Chemotherapy-Induced Peripheral Neuropathy via Activating the Gas6\/MerTK Signaling Pathway to Reduce Neuroinflammation","volume":"73","author":"Yang","year":"2025","journal-title":"J. Agric. Food Chem."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"E1825","DOI":"10.1073\/pnas.1621433114","article-title":"Inhibition of \u03b19\u03b110 nicotinic acetylcholine receptors prevents chemotherapy-induced neuropathic pain","volume":"114","author":"Romero","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref_148","doi-asserted-by":"crossref","unstructured":"Huynh, P.N., Giuvelis, D., Christensen, S., Tucker, K.L., and McIntosh, J.M. (2019). RgIA4 Accelerates Recovery from Paclitaxel-Induced Neuropathic Pain in Rats. Mar. Drugs, 18.","DOI":"10.3390\/md18010012"},{"key":"ref_149","doi-asserted-by":"crossref","unstructured":"Wang, A., Bai, F., and Hua, J. (2025). Microalgal bioactives as emerging nutritional regulators of apoptosis and neuroplasticity: Targeting metabolic dysfunction in aging, neurodegenerative diseases, and cancer. Front. Pharmacol., 16.","DOI":"10.3389\/fphar.2025.1643426"},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/s41577-019-0147-2","article-title":"Pain and immunity: Implications for host defence","volume":"19","author":"Baral","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"ref_151","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.it.2016.10.001","article-title":"Nociceptor Sensory Neuron-Immune Interactions in Pain and Inflammation","volume":"38","author":"Verri","year":"2017","journal-title":"Trends Immunol."},{"key":"ref_152","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0306-4522(02)00274-9","article-title":"Coexpression of alpha 9 and alpha 10 nicotinic acetylcholine receptors in rat dorsal root ganglion neurons","volume":"115","author":"Lips","year":"2002","journal-title":"Neuroscience"},{"key":"ref_153","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.lfs.2004.05.031","article-title":"Characterization of the human nicotinic acetylcholine receptor subunit alpha (alpha) 9 (CHRNA9) and alpha (alpha) 10 (CHRNA10) in lymphocytes","volume":"76","author":"Peng","year":"2004","journal-title":"Life Sci."},{"key":"ref_154","doi-asserted-by":"crossref","first-page":"173320","DOI":"10.1016\/j.ejphar.2020.173320","article-title":"The \u03b19\u03b110 nicotinic acetylcholine receptors antagonist \u03b1-conotoxin RgIA reverses colitis signs in murine dextran sodium sulfate model","volume":"883","author":"AlSharari","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"ref_155","doi-asserted-by":"crossref","unstructured":"Huynh, P.N., Christensen, S.B., and McIntosh, J.M. (2022). RgIA4 Prevention of Acute Oxaliplatin-Induced Cold Allodynia Requires \u03b19-Containing Nicotinic Acetylcholine Receptors and CD3(+) T-Cells. Cells, 11.","DOI":"10.3390\/cells11223561"},{"key":"ref_156","doi-asserted-by":"crossref","unstructured":"Gaud\u00eancio, S.P., Bayram, E., Luki\u0107 Bilela, L., Cueto, M., D\u00edaz-Marrero, A.R., Haznedaroglu, B.Z., Jimenez, C., Mandalakis, M., Pereira, F., and Reyes, F. (2023). Advanced Methods for Natural Products Discovery: Bioactivity Screening, Dereplication, Metabolomics Profiling, Genomic Sequencing, Databases and Informatic Tools, and Structure Elucidation. Mar. Drugs, 21.","DOI":"10.3390\/md21050308"},{"key":"ref_157","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.jconrel.2015.09.032","article-title":"Stabilization of cysteine-linked antibody drug conjugates with N-aryl maleimides","volume":"220","author":"Christie","year":"2015","journal-title":"J. Control Release"},{"key":"ref_158","doi-asserted-by":"crossref","unstructured":"Pavlicevic, M., Maestri, E., and Marmiroli, M. (2020). Marine Bioactive Peptides-An Overview of Generation, Structure and Application with a Focus on Food Sources. Mar. Drugs, 18.","DOI":"10.3390\/md18080424"},{"key":"ref_159","doi-asserted-by":"crossref","first-page":"487","DOI":"10.4155\/fmc-2020-0123","article-title":"Marine sponge-derived\/inspired drugs and their applications in drug delivery systems","volume":"13","author":"Ramanjooloo","year":"2021","journal-title":"Future Med. Chem."},{"key":"ref_160","doi-asserted-by":"crossref","unstructured":"Diao, X., Han, H., Li, B., Guo, Z., Fu, J., and Wu, W. (2023). The Rare Marine Bioactive Compounds in Neurological Disorders and Diseases: Is the Blood-Brain Barrier an Obstacle or a Target?. Mar. Drugs, 21.","DOI":"10.3390\/md21070406"},{"key":"ref_161","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.jconrel.2020.01.006","article-title":"Novel and revisited approaches in nanoparticle systems for buccal drug delivery","volume":"320","author":"Macedo","year":"2020","journal-title":"J. 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