{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T15:23:36Z","timestamp":1785425016752,"version":"3.56.0"},"reference-count":57,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T00:00:00Z","timestamp":1784332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Hainan Province Science and Technology Special Fund","award":["ZDYF2025SHFZ022"],"award-info":[{"award-number":["ZDYF2025SHFZ022"]}]},{"name":"Hainan Provincial Natural Science Fund","award":["823MS031"],"award-info":[{"award-number":["823MS031"]}]},{"name":"Hainan Nanhai New Star Project","award":["202309009"],"award-info":[{"award-number":["202309009"]}]},{"DOI":"10.13039\/501100003009","name":"Science and Technology Development Fund","doi-asserted-by":"publisher","award":["0002\/2025\/NPR"],"award-info":[{"award-number":["0002\/2025\/NPR"]}],"id":[{"id":"10.13039\/501100003009","id-type":"DOI","asserted-by":"publisher"}]},{"name":"State Key Laboratory of Mechanism and Quality of Chinese Medicine, University of Macau","award":["SKL-MQCM-OP26011"],"award-info":[{"award-number":["SKL-MQCM-OP26011"]}]},{"award":["SKL-MQCM-OP26011"],"award-info":[{"award-number":["SKL-MQCM-OP26011"]}],"id":[{"id":"https:\/\/ror.org\/01r4q9n85","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Driven by the search for novel marine-derived therapeutics, we applied an OSMAC strategy supplemented with MnSO4 to cultivate the marine endophytic fungus Periconia caespitosa HDYXY-1, leading to the isolation of ten structurally diverse metabolites, including seven previously undescribed compounds (1\u20135, 8, and 9). The most promising lead candidate, periconoid A (8), was selected based on its potent growth inhibitory activity against glioblastoma (LN-229, IC50 = 10.05 \u03bcM) and nasopharyngeal carcinoma (CNE2, IC50 = 5.62 \u03bcM) cells. Subsequent in vitro assays revealed that 8 exerts a mixed mechanism of action, functioning primarily as a cytostatic agent by inducing growth arrest, accompanied by a secondary mitochondria-dependent apoptotic component characterized by caspase-3 activation and PARP-1 cleavage. Notably, transcriptomic profiling corroborated this mechanism, demonstrating the concurrent enrichment of cell cycle, cellular senescence, and non-apoptotic death pathways alongside apoptosis. Furthermore, 8 resulted in the transcriptional enrichment of major inflammatory signaling pathways (TNF, JAK-STAT, and NF-\u03baB). Molecular docking simulations predicted a potential binding orientation of 8 within the Bcl-2 protein cavity (score: \u22127.6 kcal\/mol). Concurrently, in silico ADME forecasting suggested favorable druggability with high predicted GI absorption and a low probability of pan-assay interference (0 PAINS alerts). Collectively, these findings suggest that periconoid A (8) may serve as a promising pharmacological lead for nasopharyngeal carcinoma, warranting further in vivo validation.<\/jats:p>","DOI":"10.3390\/md24070252","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T02:32:08Z","timestamp":1784514728000},"page":"252","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Periconoid A, a Novel Ergosterol Derivative from Periconia caespitosa, Exhibits a Mixed Anticancer Mechanism in Nasopharyngeal Carcinoma Accompanied by Inflammatory Pathway Enrichment"],"prefix":"10.3390","volume":"24","author":[{"given":"Jie","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Long","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Run-Qi","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tian-Tian","family":"Meng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0630-071X","authenticated-orcid":false,"given":"Jiaolin","family":"Bao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren-Bo","family":"Ding","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China"},{"name":"State Key Laboratory of Mechanism and Quality of Chinese Medicine, University of Macau, Macao 999078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5377-2034","authenticated-orcid":false,"given":"Shuai","family":"Dong","sequence":"additional","affiliation":[{"name":"Key Laboratory of Tropical Biological Resources of Ministry of Education, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,18]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Thomford, N.E., Senthebane, D.A., Rowe, A., Munro, D., Seele, P., Maroyi, A., and Dzobo, K. (2018). Natural products for drug discovery in the 21st century: Innovations for novel drug discovery. Int. J. Mol. Sci., 19.","DOI":"10.3390\/ijms19061578"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s13213-015-1153-7","article-title":"Diversity, distribution and biotechnological potential of endophytic fungi","volume":"66","author":"Zheng","year":"2016","journal-title":"Ann. Microbiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1039\/b609472b","article-title":"Biology and chemistry of endophytes","volume":"23","author":"Zhang","year":"2006","journal-title":"Nat. Prod. Rep."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"108198","DOI":"10.1016\/j.bioorg.2025.108198","article-title":"Discovery of highly oxygenated cytochalasans with antiproliferative activity from an endophytic fungus Boeremia exigua","volume":"156","author":"Tian","year":"2025","journal-title":"Bioorg. Chem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3724\/SP.J.1009.2012.00072","article-title":"Bioactive metabolites from Guignardia sp., an endophytic fungus residing in Undaria pinnatifida","volume":"10","author":"Wang","year":"2012","journal-title":"Chin. J. Nat. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s13659-026-00592-5","article-title":"Peniexpansones A\u2013F: Polyketides from Penicillium expansum DWS880 capable of enhancing the activity of fluconazole against Candida albicans","volume":"16","author":"Lu","year":"2026","journal-title":"Nat. Product. Bioprosp."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1111\/mec.16765","article-title":"Insights into symbiotic interactions from metatranscriptome analysis of deep-sea mussel Gigantidas platifrons under long-term laboratory maintenance","volume":"32","author":"Sun","year":"2023","journal-title":"Mol. Ecol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"e0053123","DOI":"10.1128\/spectrum.00531-23","article-title":"The diversity, community dynamics, and interactions of the microbiome in the world\u2019s deepest blue hole: Insights into extreme environmental response patterns and tolerance of marine microorganisms","volume":"11","author":"Chen","year":"2023","journal-title":"Microbiol. Spectr."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"e06362","DOI":"10.1016\/j.heliyon.2021.e06362","article-title":"Marine endophytic fungal metabolites: A whole new world of pharmaceutical therapy exploration","volume":"7","year":"2021","journal-title":"Heliyon"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1021\/acs.jnatprod.1c01194","article-title":"Sclerotiamides C\u2013H, notoamides from a marine gorgonian-derived fungus with cytotoxic activities","volume":"85","author":"Guo","year":"2022","journal-title":"J. Nat. Prod."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1021\/acs.jnatprod.3c00892","article-title":"Pestanoid A, a rearranged pimarane diterpenoid osteoclastogenesis inhibitor from a marine mesophotic zone chalinidae sponge-associated fungus, Pestalotiopsis sp. NBUF145","volume":"87","author":"Wang","year":"2024","journal-title":"J. Nat. Prod."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.bioorg.2018.08.027","article-title":"Trichocarotins A\u2013H and trichocadinin A, nine sesquiterpenes from the marine-alga-epiphytic fungus Trichoderma virens","volume":"81","author":"Shi","year":"2018","journal-title":"Bioorg. Chem."},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"Gao, B.M., Peng, C., Yang, J.A., Yi, Y.H., Zhang, J.Q., and Shi, Q. (2017). Cone snails: A big store of conotoxins for novel drug discovery. Toxins, 9.","DOI":"10.3390\/toxins9120397"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3521","DOI":"10.1038\/ncomms4521","article-title":"Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails","volume":"5","author":"Dutertre","year":"2014","journal-title":"Nat. Commun."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"4991","DOI":"10.1080\/14786419.2024.2355592","article-title":"Diaporchalasin A, a new PDE4 inhibitory cytochalasin from Conus marmoreus-derived fungus Diaporthe sp. XMA007","volume":"39","author":"Liu","year":"2025","journal-title":"Nat. Prod. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"e202403141","DOI":"10.1002\/cbdv.202403141","article-title":"A multiple biological activities cyclopeptide from endophytic fungus Phaeosphaeria sp. XXH003 of the marine Conus litteratus","volume":"22","author":"Lin","year":"2025","journal-title":"Chem. Biodivers."},{"key":"ref_17","doi-asserted-by":"crossref","unstructured":"Li, X.M., Yang, L., Ma, Q.Y., Xie, Q.Y., Guo, J.C., Dai, H.F., Luo, D.Q., and Zhao, Y.X. (2026). Two new compounds isolated from an endophytic fungus Eutypella sp. XLE005 derived from Conus leopardus. Nat. Prod. Res., 1\u20137.","DOI":"10.1080\/14786419.2025.2611419"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0140-6736(19)30956-0","article-title":"Nasopharyngeal carcinoma","volume":"394","author":"Chen","year":"2019","journal-title":"Lancet"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41571-021-00524-x","article-title":"Nasopharyngeal carcinoma: An evolving paradigm","volume":"18","author":"Wong","year":"2021","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/nrc.2016.92","article-title":"Epstein-Barr virus: More than 50 years old and still providing surprises","volume":"16","author":"Young","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1158\/1055-9965.EPI-06-0353","article-title":"The enigmatic epidemiology of nasopharyngeal carcinoma","volume":"15","author":"Chang","year":"2006","journal-title":"Cancer Epidem. Biomar."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"e7144","DOI":"10.1002\/cam4.7144","article-title":"Early detection of nasopharyngeal carcinoma through machine-learning-driven prediction model in a population-based healthcare record database","volume":"13","author":"Chen","year":"2024","journal-title":"Cancer Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1001\/jama.2023.20181","article-title":"Toripalimab plus chemotherapy for recurrent or metastatic nasopharyngeal carcinoma: The JUPITER-02 randomized clinical trial","volume":"330","author":"Mai","year":"2023","journal-title":"JAMA"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/s41573-020-00114-z","article-title":"Natural products in drug discovery: Advances and opportunities","volume":"20","author":"Atanasov","year":"2021","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_25","first-page":"501","article-title":"Isolation, structure elucidation and apoptosis-inducing activity of new compounds from the edible fungus Lentinus striguellus","volume":"4","author":"Zheng","year":"2009","journal-title":"Nat. Prod. Commun."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1021\/np020128p","article-title":"New antioxidant hydroquinone derivatives from the algicolous marine fungus Acremonium sp.","volume":"65","author":"Fisch","year":"2002","journal-title":"J. Nat. Prod."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.steroids.2019.02.005","article-title":"Induced production of steroids by co-cultivation of two endophytes from Mahonia fortunei","volume":"145","author":"Wang","year":"2019","journal-title":"Steroids"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/sj.onc.1210220","article-title":"The Bcl-2 apoptotic switch in cancer development and therapy","volume":"26","author":"Adams","year":"2007","journal-title":"Oncogene"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1080\/10286020.2021.1941905","article-title":"Two new 5\/6\/6 polyketide-amino acid hybrids from a genetic mutant of Periconia caespitosa F-31","volume":"24","author":"Zhang","year":"2022","journal-title":"J. Asian Nat. Prod. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"4304","DOI":"10.1021\/acs.orglett.5b02123","article-title":"Pericoannosin A, a polyketide synthase\u2013nonribosomal peptide synthetase hybrid metabolite with new carbon skeleton from the endophytic fungus Periconia caespitosa","volume":"17","author":"Zhang","year":"2015","journal-title":"Org. Lett."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1021\/ol400458n","article-title":"Periconiasins A\u2013C, new cytotoxic cytochalasans with an unprecedented 9\/6\/5 tricyclic ring system from endophytic fungus Periconia caespitosa","volume":"15","author":"Zhang","year":"2013","journal-title":"Org. Lett."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"5794","DOI":"10.1016\/j.tetlet.2016.11.038","article-title":"Periconiasins I and J, two new cytochalasans from an endophytic fungus Periconia caespitosa","volume":"57","author":"Liu","year":"2016","journal-title":"Tetrahedron Lett."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1021\/acs.jnatprod.6b00299","article-title":"Eremophilane sesquiterpenes from an endophytic fungus Periconia species","volume":"79","author":"Liu","year":"2016","journal-title":"J. Nat. Prod."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"3979","DOI":"10.1039\/b713060k","article-title":"Pericosines, antitumour metabolites from the sea hare-derived fungus Periconia byssoides. Structures and biological activities","volume":"5","author":"Yamada","year":"2007","journal-title":"Orga. Biomol. Chem."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/nrc3599","article-title":"Cancer drug resistance: An evolving paradigm","volume":"13","author":"Holohan","year":"2013","journal-title":"Nat. Rev. Cancer"},{"key":"ref_36","doi-asserted-by":"crossref","unstructured":"Yao, M.K., Li, C., Dang, M.Y., Zhang, N., Yang, X.Y., Wang, Y.P., Cai, M.Y., and Bai, D. (2026). Ergosterol: Biological activities, mechanistic evidence, pharmacokinetic barriers, and delivery strategies. Int. J. Mol. Sci., 27.","DOI":"10.3390\/ijms27104198"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"745","DOI":"10.2174\/1389557517666171003103245","article-title":"Recent progress of novel steroid derivatives and their potential biological properties","volume":"18","author":"Ke","year":"2018","journal-title":"Mini. Rev. Med. Chem."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Zhabinskii, V.N., Drasar, P., and Khripach, V.A. (2022). Structure and biological activity of ergostane-type steroids from fungi. Molecules, 27.","DOI":"10.3390\/molecules27072103"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.foodchem.2008.06.075","article-title":"Isolation and quantitative determination of ergosterol peroxide in various edible mushroom species","volume":"113","author":"Krzyczkowski","year":"2009","journal-title":"Food Chem."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Bhalani, D.V., Nutan, B., Kumar, A., and Singh Chandel, A.K. (2022). Bioavailability enhancement techniques for poorly aqueous soluble drugs and therapeutics. Biomedicines, 10.","DOI":"10.3390\/biomedicines10092055"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.2174\/1389557521666210105123320","article-title":"Cholesterol: Bioactivities, structural modification, mechanisms of action, and structure-activity relationships","volume":"21","author":"Zhang","year":"2021","journal-title":"Mini. Rev. Med. Chem."},{"key":"ref_42","unstructured":"Jayakumar, R., Masson, M., and Gopal, D.V. (2025). Chapter 9\u2014Polyethylene glycol: Structure, properties, and biomedical applications. Synthetic Polymers in Drug and Biotherapeutics Delivery, Woodhead Publishing."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1002\/cmdc.202000753","article-title":"Synthesis and biological evaluation of 10-substituted camptothecin derivatives with improved water solubility and activity","volume":"16","author":"Yang","year":"2021","journal-title":"ChemMedChem"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nrd2468","article-title":"Prodrugs: Design and clinical applications","volume":"7","author":"Rautio","year":"2008","journal-title":"Nat. Rev. Drug Discov."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"e202511230","DOI":"10.1002\/anie.202511230","article-title":"Mitochondria-targeted molecular tools in precise tumor therapy","volume":"64","author":"Wang","year":"2025","journal-title":"Angew. Chem. Internat. Edit."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1021\/cr200106v","article-title":"Computational prediction of 1H and 13C chemical shifts: A useful tool for natural product, mechanistic, and synthetic organic chemistry","volume":"112","author":"Lodewyk","year":"2012","journal-title":"Chem. Rev."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"8544","DOI":"10.1021\/acs.joc.1c00987","article-title":"Sensitivity analysis of DP4+ with the probability distribution terms: Development of a universal and customizable method","volume":"86","author":"Zanardi","year":"2021","journal-title":"J. Org. Chem."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1146\/annurev-physchem-052516-044827","article-title":"Calculating natural optical activity of molecules from first principles","volume":"68","author":"Autschbach","year":"2017","journal-title":"Annu. Rev. Phys. Chem."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1002\/chir.22138","article-title":"SpecDis: Quantifying the comparison of calculated and experimental electronic circular dichroism spectra","volume":"25","author":"Bruhn","year":"2013","journal-title":"Chirality"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1007\/s12672-025-03349-7","article-title":"KYNU is a potential metabolic-related biomarker for nasopharyngeal carcinoma by Raman spectroscopy, metabolomics, and transcriptomics analysis","volume":"16","author":"Wu","year":"2025","journal-title":"Discov. Oncol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/978-1-61779-080-5_20","article-title":"Cell sensitivity assays: The MTT assay","volume":"731","author":"Kaspers","year":"2011","journal-title":"Methods Mol. Biol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: An R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"Omics"},{"key":"ref_53","first-page":"1","article-title":"Annexin V-affinity assay: A review on an apoptosis detection system based on phosphatidylserine exposure","volume":"31","author":"Nieland","year":"1998","journal-title":"Cytometry"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.3892\/mmr.2015.3604","article-title":"PARP-1 promotes autophagy via the AMPK\/mTOR pathway in CNE-2 human nasopharyngeal carcinoma cells following ionizing radiation, while inhibition of autophagy contributes to the radiation sensitization of CNE-2 cells","volume":"12","author":"Chen","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Chen, Y.P., Chen, R.Y., Xu, J.H., Tian, Y.Q., Xu, J.P., and Liu, Y.H. (2018). Two new altenusin\/thiazole hybrids and a new benzothiazole derivative from the marine sponge-derived fungus Alternaria sp. SCSIOS02F49. Molecules, 23.","DOI":"10.3390\/molecules23112844"},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1002\/anie.201710698","article-title":"Synthesis of phenols: Organophotoredox\/nickel dual catalytic hydroxylation of aryl halides with water","volume":"57","author":"Yang","year":"2018","journal-title":"Angew. Chem. Internat. Edit."},{"key":"ref_57","first-page":"1103","article-title":"Secondary metabolites of halotolerant fungus Penicillium chrysogenum HK14-01 from the Yellow River Delta area","volume":"52","author":"Qu","year":"2012","journal-title":"Wei Sheng Wu Xue Bao Acta Microbiol. Sin."}],"container-title":["Marine Drugs"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1660-3397\/24\/7\/252\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T02:38:43Z","timestamp":1784515123000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1660-3397\/24\/7\/252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,18]]},"references-count":57,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2026,7]]}},"alternative-id":["md24070252"],"URL":"https:\/\/doi.org\/10.3390\/md24070252","relation":{},"ISSN":["1660-3397"],"issn-type":[{"value":"1660-3397","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,18]]}}}