{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:58:58Z","timestamp":1785430738333,"version":"3.56.0"},"reference-count":26,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T00:00:00Z","timestamp":1785024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Natural Science Research Project of Anhui Provincial Department of Education","award":["2025AHGXZK30205"],"award-info":[{"award-number":["2025AHGXZK30205"]}]},{"award":["2025AHGXZK30205"],"award-info":[{"award-number":["2025AHGXZK30205"]}],"id":[{"id":"https:\/\/ror.org\/012m7k033","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Open Research Fund of the Anhui Engineering Technology Research Center of Biochemical Pharmaceutical","award":["2025SYKFD12"],"award-info":[{"award-number":["2025SYKFD12"]}]},{"name":"Anhui Provincial College Student Innovation and Entrepreneurship Training Program","award":["S202510367168"],"award-info":[{"award-number":["S202510367168"]}]},{"name":"Youth Incubation Project of the National Natural Science Foundation of China","award":["2024byfy006"],"award-info":[{"award-number":["2024byfy006"]}]},{"award":["2024byfy006"],"award-info":[{"award-number":["2024byfy006"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mar. Drugs","Marine Drugs"],"abstract":"<jats:p>To fully explore the metabolites of the mangrove endophytic fungus Penicillium janthinellum HDN13-309, which can produce Epipolythiodioxopiperazine (ETP) compounds with noteworthy anti-tumor activities, HPLC-MS analysis was applied, and five new gliovirin-like alkaloids, penicisulfuranols G\u2013K (1\u20135), were target-directed acquired. Furthermore, penicisulfuranols G (1) and H (2) were distinguished by a double bond between C-5\/C-6 and ortho-hydroxylation of C-7\/C-8 on the 1,2-oxazadecaline moiety. Their structures, including absolute configurations, were elucidated based on NMR spectroscopy, ECD measurements, and high-resolution mass spectrometry, as well as by comparison with the literature. Penicisulfuranols I\u2013K (3\u20135) showed promising cytotoxicity against four tumor cell lines (HCT116, HeLa, HL-60, and K562) with IC50 values ranging from 0.1 to 9.9 \u03bcM.<\/jats:p>","DOI":"10.3390\/md24080258","type":"journal-article","created":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T05:49:27Z","timestamp":1785131367000},"page":"258","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Gliovirin-like Alkaloids with Spirocyclic Skeletons from the Mangrove Endophytic Fungus Penicillium\u00a0janthinellum HDN13-309"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8490-087X","authenticated-orcid":false,"given":"Haotian","family":"Wang","sequence":"first","affiliation":[{"name":"School of Pharmacy, Bengbu Medical University, Bengbu 233030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runyu","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Bengbu Medical University, Bengbu 233030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanying","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Bengbu Medical University, Bengbu 233030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Feng","sequence":"additional","affiliation":[{"name":"School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Bengbu Medical University, Bengbu 233030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajuan","family":"Cong","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Bengbu Medical University, Bengbu 233030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7191-2002","authenticated-orcid":false,"given":"Dehai","family":"Li","sequence":"additional","affiliation":[{"name":"School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Bengbu Medical University, Bengbu 233030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meilin","family":"Zhu","sequence":"additional","affiliation":[{"name":"School of Pharmacy, Bengbu Medical University, Bengbu 233030, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1039\/C3NP70097F","article-title":"Epidithiodioxopiperazines. occurrence, synthesis and biogenesis","volume":"31","author":"Welch","year":"2014","journal-title":"Nat. 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