{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T19:02:11Z","timestamp":1785438131712,"version":"3.56.0"},"reference-count":85,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T00:00:00Z","timestamp":1785283200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360696"],"award-info":[{"award-number":["82360696"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"award":["82360696"],"award-info":[{"award-number":["82360696"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012547","name":"Guangxi Natural Science Foundation","doi-asserted-by":"publisher","award":["2023GXNSFBA026240"],"award-info":[{"award-number":["2023GXNSFBA026240"]}],"id":[{"id":"10.13039\/100012547","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangxi Key Laboratory of Tumor Immunology and Microenvironmental Regulation","award":["2023KF001"],"award-info":[{"award-number":["2023KF001"]}]},{"DOI":"10.13039\/501100011827","name":"Guangxi Medical University","doi-asserted-by":"publisher","award":["2024-ZC-15"],"award-info":[{"award-number":["2024-ZC-15"]}],"id":[{"id":"10.13039\/501100011827","id-type":"DOI","asserted-by":"publisher"}]},{"award":["2024-ZC-15"],"award-info":[{"award-number":["2024-ZC-15"]}],"id":[{"id":"https:\/\/ror.org\/03dveyr97","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mar. Drugs","Marine Drugs"],"abstract":"<jats:p>Rare actinomycetes have emerged as important yet underexplored reservoirs for the discovery of novel bioactive compounds. Microbispora, a genus of rare actinomycetes, is widely distributed across diverse ecological niches, including terrestrial soils, marine-associated environments, plant-associated ecosystems, and insect-derived environments. To date, 81 secondary metabolites have been reported from this genus, encompassing quinones, chromones and chromanones, macrolides, other polyketides, alkaloids, peptides and diketopiperazines, and miscellaneous structural classes. These metabolites display antimicrobial, anticancer, neuroprotective, antiviral, plant growth-promoting, and enzyme inhibitory activities. Beyond systematically cataloging these compounds, this review provides an integrated analysis of their structure\u2013activity relationships (SAR), biosynthetic origins, and biological significance. In addition, the biosynthetic potential of Microbispora is discussed based on reported genomic studies, highlighting the presence of numerous predicted and poorly characterized biosynthetic gene clusters. This review provides an integrative perspective on Microbispora as an underexplored but promising source of structurally diverse and bioactive natural products for drug discovery.<\/jats:p>","DOI":"10.3390\/md24080263","type":"journal-article","created":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T17:01:46Z","timestamp":1785344506000},"page":"263","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Underexplored Genus Microbispora: A Treasure Trove of Secondary Metabolites with Diverse Chemistry, Potent Bioactivities, and Biosynthetic Insights"],"prefix":"10.3390","volume":"24","author":[{"given":"Mingqi","family":"Chen","sequence":"first","affiliation":[{"name":"Guangxi Key Laboratory for Bioactive Molecules Research and Evaluation, Guangxi Key Laboratory of Composition-Activity Relationship of Traditional Chinese Medicine, School of Pharmacy, Guangxi Medical University, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingyun","family":"Song","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory for Bioactive Molecules Research and Evaluation, Guangxi Key Laboratory of Composition-Activity Relationship of Traditional Chinese Medicine, School of Pharmacy, Guangxi Medical University, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory for Bioactive Molecules Research and Evaluation, Guangxi Key Laboratory of Composition-Activity Relationship of Traditional Chinese Medicine, School of Pharmacy, Guangxi Medical University, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4614-4857","authenticated-orcid":false,"given":"Shaowei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Microbial Chemistry, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wongsakorn","family":"Phongsopitanun","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Microbiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6813-8274","authenticated-orcid":false,"given":"Chenghang","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Microbial Chemistry, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4046-2643","authenticated-orcid":false,"given":"Hongwei","family":"Guo","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory for Bioactive Molecules Research and Evaluation, Guangxi Key Laboratory of Composition-Activity Relationship of Traditional Chinese Medicine, School of Pharmacy, Guangxi Medical University, Nanning 530021, China"},{"name":"Key Laboratory of Longevity and Aging-Related Diseases of Chinese Ministry of Education & Center for Translational Medicine, Guangxi Medical University, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinpei","family":"Lu","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory for Bioactive Molecules Research and Evaluation, Guangxi Key Laboratory of Composition-Activity Relationship of Traditional Chinese Medicine, School of Pharmacy, Guangxi Medical University, Nanning 530021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,7,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1021\/acs.jnatprod.9b01285","article-title":"Natural products as sources of new drugs over the nearly four decades from 01\/1981 to 09\/2019","volume":"83","author":"Newman","year":"2020","journal-title":"J. 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