{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:30:28Z","timestamp":1791653428511,"version":"4.3.4"},"reference-count":479,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mar. Drugs","Marine Drugs"],"abstract":"<jats:p>Autism spectrum disorder (ASD) and epilepsy are complex, frequently co-occurring neurodevelopmental and neurological disorders that share key mechanisms, such as altered neurotransmission, oxidative stress, neuroinflammation, and gut\u2013brain axis disruption. Despite pharmacological advances, current treatments often provide only partial relief and are associated with significant side effects. The comorbidity of ASD and epilepsy, affecting millions worldwide, remains under-recognised and poorly addressed, imposing a profound burden on patients, families, and healthcare systems through reduced quality of life, increased caregiving demands, and substantial social and economic costs. This review highlights the convergent pathways shared between ASD and epilepsy, including immune dysregulation, synaptic dysfunction, and metabolic imbalance, which create opportunities for unified therapeutic strategies. Marine algae have emerged as a sustainable source of bioactive compounds offering a unique potential to address these overlapping pathologies. Algal polyunsaturated fatty acids, carotenoids, polyphenols, polysaccharides, and vitamins have antioxidant, anti-inflammatory, neuroprotective, and microbiota-modulating activities. By addressing both the biological underpinnings and clinical burden of ASD\u2013epilepsy comorbidity, algae-based strategies represent a novel and ecologically sustainable direction for mitigating ASD\u2013epilepsy comorbidity and advancing marine-inspired neurotherapeutics.<\/jats:p>","DOI":"10.3390\/md24080277","type":"journal-article","created":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T16:35:16Z","timestamp":1786379716000},"page":"277","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Healing from the Ocean: Targeting Shared Mechanisms in Autism and Epilepsy Using Algae-Derived Compounds"],"prefix":"10.3390","volume":"24","author":[{"given":"Dorit","family":"Avni","sequence":"first","affiliation":[{"name":"Translational Biocompounds Research Group, MIGAL-Galilee Research Institute, Kiryat Shmona 1101600, Israel"},{"name":"The Department of Biotechnology, Tel Hai University, Kiryat Shmona 1220800, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orly","family":"Weissberg","sequence":"additional","affiliation":[{"name":"Translational Biocompounds Research Group, MIGAL-Galilee Research Institute, Kiryat Shmona 1101600, Israel"},{"name":"The Department of Biotechnology, Tel Hai University, Kiryat Shmona 1220800, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noam","family":"Pintel","sequence":"additional","affiliation":[{"name":"Translational Biocompounds Research Group, MIGAL-Galilee Research Institute, Kiryat Shmona 1101600, Israel"},{"name":"The Department of Biotechnology, Tel Hai University, Kiryat Shmona 1220800, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liat","family":"Izraelov","sequence":"additional","affiliation":[{"name":"Translational Biocompounds Research Group, MIGAL-Galilee Research Institute, Kiryat Shmona 1101600, Israel"},{"name":"The Department of Biotechnology, Tel Hai University, Kiryat Shmona 1220800, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Weissberg, O., and Elliott, E. 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