{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T04:30:29Z","timestamp":1786681829014,"version":"build-2736575974"},"reference-count":32,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Guangxi Natural Science Foundation","award":["2026GXNSFD202160002"],"award-info":[{"award-number":["2026GXNSFD202160002"]}]},{"name":"Guangxi Science and Technology Program","award":["LT2600640033"],"award-info":[{"award-number":["LT2600640033"]}]},{"name":"Bagui Youth Talent Development Program, Guangxi Special Support Program for Maritime Economic Talent Cultivation","award":["2025XHRC27"],"award-info":[{"award-number":["2025XHRC27"]}]},{"name":"High-Level Talent Training Project Foundation of Guangxi University of Chinese Medicine","award":["202407"],"award-info":[{"award-number":["202407"]}]},{"name":"Innovation Project of Guangxi Graduate Education","award":["YCSW2025457"],"award-info":[{"award-number":["YCSW2025457"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mar. Drugs","Marine Drugs"],"abstract":"<jats:p>Two new indole derivatives (1 and 2), along with fourteen known indole and polyketide compounds, were characterized from the Beibu Gulf coral-derived fungus Pestalotiopsis microspora GXIMD 02530. Their structures and absolute configurations were determined by comprehensive spectroscopic analysis, electronic circular dichroism (ECD) calculations, and single-crystal X-ray diffraction. Structurally, furoindolin A (1) was obtained as a rare racemic 6\/5\/5 tricyclic indole derivative incorporating a dihydrofuranone ring, which was further separated into a pair of enantiomers by chiral chromatographic resolution. Compounds (\u00b1)-1, 3, 4, and 6\u201312 exhibited inhibition of LPS-induced NF-\u03baB luciferase activities. Phomopsilactone (10) displayed antibacterial activities against Staphylococcus epidermidis, Bacillus subtilis, and Staphylococcus aureus, with MIC values of 15.6, 31.25, and 62.5 \u03bcg\/mL, respectively. Our findings would expand the chemical variety of indole derivatives and highlight furoindolin A (+)-1 as a promising chemical template for further biosynthetic and anti-inflammatory pharmacological investigation.<\/jats:p>","DOI":"10.3390\/md24080279","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T07:57:26Z","timestamp":1786521446000},"page":"279","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Two New Indole Derivatives from the Beibu Gulf Coral-Derived Fungus Pestalotiopsis microspora GXIMD 02530"],"prefix":"10.3390","volume":"24","author":[{"given":"Hui","family":"Shi","sequence":"first","affiliation":[{"name":"Guangxi Key Laboratory of Marine Drugs, University Engineering Research Center of High-Efficient Utilization of Marine Traditional Chinese Medicine Resources, Guangxi, Technology Innovation Center for the Development and Utilization of Marine Drugs and Bioproducts for Beibu Gulf, Ministry of Natural Resources, Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guihua","family":"Yang","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Marine Drugs, University Engineering Research Center of High-Efficient Utilization of Marine Traditional Chinese Medicine Resources, Guangxi, Technology Innovation Center for the Development and Utilization of Marine Drugs and Bioproducts for Beibu Gulf, Ministry of Natural Resources, Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolin","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Marine Drugs, University Engineering Research Center of High-Efficient Utilization of Marine Traditional Chinese Medicine Resources, Guangxi, Technology Innovation Center for the Development and Utilization of Marine Drugs and Bioproducts for Beibu Gulf, Ministry of Natural Resources, Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaoping","family":"Lin","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Marine Drugs, University Engineering Research Center of High-Efficient Utilization of Marine Traditional Chinese Medicine Resources, Guangxi, Technology Innovation Center for the Development and Utilization of Marine Drugs and Bioproducts for Beibu Gulf, Ministry of Natural Resources, Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Humu","family":"Lu","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Marine Drugs, University Engineering Research Center of High-Efficient Utilization of Marine Traditional Chinese Medicine Resources, Guangxi, Technology Innovation Center for the Development and Utilization of Marine Drugs and Bioproducts for Beibu Gulf, Ministry of Natural Resources, Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7524-8049","authenticated-orcid":false,"given":"Chenghai","family":"Gao","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Marine Drugs, University Engineering Research Center of High-Efficient Utilization of Marine Traditional Chinese Medicine Resources, Guangxi, Technology Innovation Center for the Development and Utilization of Marine Drugs and Bioproducts for Beibu Gulf, Ministry of Natural Resources, Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8327-3108","authenticated-orcid":false,"given":"Yonghong","family":"Liu","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Marine Drugs, University Engineering Research Center of High-Efficient Utilization of Marine Traditional Chinese Medicine Resources, Guangxi, Technology Innovation Center for the Development and Utilization of Marine Drugs and Bioproducts for Beibu Gulf, Ministry of Natural Resources, Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2114-1609","authenticated-orcid":false,"given":"Xiaowei","family":"Luo","sequence":"additional","affiliation":[{"name":"Guangxi Key Laboratory of Marine Drugs, University Engineering Research Center of High-Efficient Utilization of Marine Traditional Chinese Medicine Resources, Guangxi, Technology Innovation Center for the Development and Utilization of Marine Drugs and Bioproducts for Beibu Gulf, Ministry of Natural Resources, Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"100050","DOI":"10.1016\/j.pscia.2024.100050","article-title":"Natural product databases for drug discovery: Features and applications","volume":"2","author":"Zeng","year":"2024","journal-title":"Pharm. 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