{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T04:22:24Z","timestamp":1787458944454,"version":"build-2736575974"},"reference-count":74,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T00:00:00Z","timestamp":1787270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004827","name":"University of Mauritius","doi-asserted-by":"crossref","award":["Q0200"],"award-info":[{"award-number":["Q0200"]}],"id":[{"id":"10.13039\/501100004827","id-type":"DOI","asserted-by":"crossref"}]},{"award":["Q0200"],"award-info":[{"award-number":["Q0200"]}],"id":[{"id":"https:\/\/ror.org\/05cyprz33","id-type":"ROR","asserted-by":"publisher"}]},{"name":"Higher Education Commission, Mauritius","award":["INT-2018-06"],"award-info":[{"award-number":["INT-2018-06"]}]},{"name":"Anne Forrest Fund for Esophageal Cancer Research"},{"name":"CAS President\u2019s International Fellowship Initiative","award":["2026PVB0047"],"award-info":[{"award-number":["2026PVB0047"]}]},{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","award":["ORF-2026-218"],"award-info":[{"award-number":["ORF-2026-218"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]},{"award":["ORF-2026-218"],"award-info":[{"award-number":["ORF-2026-218"]}],"id":[{"id":"https:\/\/ror.org\/02f81g417","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mar. Drugs","Marine Drugs"],"abstract":"<jats:p>Marine fungi associated with sponges and brown algae are promising sources of pharmacologically active compounds. This study investigated the cytotoxic potential and metabolomic profiles of fungal strains isolated from the marine environment of Mauritius. Among the twenty extracts screened, the mycelium extracts were more cytotoxic than the broth extracts. Four extracts demonstrated the most potent activity: Aspergillus chevalieri (F2M), Aspergillus ochraceus (F25M) and Biatriospora sp. (F34M, F34B). The algal endophyte Aspergillus chevalieri (F2M) mycelium extract displayed an IC50 of 14.27 \u00b1 1.22 \u00b5g\/mL after 24 h against HepG2 cells. The sponge-associated fungi Aspergillus ochraceus (F25M) showed promising cytotoxic activities against HepG2 cells (IC50 of 8.775 \u00b1 0.78 \u00b5g\/mL) after 24 h of treatment, with a selectivity index of 2.27, and had the lowest IC50 (2.49 \u00b1 0.60 \u00b5g\/mL after 24 h; 7.14 \u00b1 3.14 \u00b5g\/mL after 48 h) against FLO-1 cells, also reducing tumor spheroid growth and integrity during the first four hours. All four extracts increased the intracellular ROS production, but only the mycelium extract of A. chevalieri (F2M) significantly increased superoxide dismutase (SOD) and catalase (CAT) activity. Metabolomic profiling identified diverse compound classes, including alkaloids, terpenoids, amino acids, anthraquinones and coumarins. The findings revealed that the marine fungi from Mauritius are promising sources of cytotoxic metabolites that require purification and subsequent confirmation and mechanistic studies.<\/jats:p>","DOI":"10.3390\/md24080289","type":"journal-article","created":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T08:14:01Z","timestamp":1787300041000},"page":"289","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cytotoxic Potential of Marine-Derived Fungi Isolated from Sponges and Brown Algae of Mauritius"],"prefix":"10.3390","volume":"24","author":[{"given":"Jessica M\u00e9lanie","family":"Wong Chin","sequence":"first","affiliation":[{"name":"Biopharmaceutical Unit, Center for Biomedical and Biomaterials Research (CBBR), University of Mauritius, Reduit 80837, Mauritius"},{"name":"Department of Agricultural and Food Science, Faculty of Agriculture, University of Mauritius, Reduit 80837, Mauritius"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annaelle","family":"Hip Kam","sequence":"additional","affiliation":[{"name":"Biopharmaceutical Unit, Center for Biomedical and Biomaterials Research (CBBR), University of Mauritius, Reduit 80837, Mauritius"},{"name":"Department of Health Sciences, Faculty of Medicine and Health Sciences, University of Mauritius, Reduit 80837, Mauritius"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8563-957X","authenticated-orcid":false,"given":"Rajesh","family":"Jeewon","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, Faculty of Medicine and Health Sciences, University of Mauritius, Reduit 80837, Mauritius"},{"name":"Honghe Center for Mountain Futures, Kunming Institute of Botany, Chinese Academy of Sciences, Honghe 654400, China"},{"name":"School of Pharmacy, Zunyi Medical University, Zunyi 563000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3761-6656","authenticated-orcid":false,"given":"Abdulwahed Fahad","family":"Alrefaei","sequence":"additional","affiliation":[{"name":"Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1211-7110","authenticated-orcid":false,"given":"Teeshan","family":"Bahorun","sequence":"additional","affiliation":[{"name":"Mauritius Research and Innovation Council, Ebene 72201, Mauritius"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daneshwar","family":"Puchooa","sequence":"additional","affiliation":[{"name":"Department of Agricultural and Food Science, Faculty of Agriculture, University of Mauritius, Reduit 80837, Mauritius"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5541-9747","authenticated-orcid":false,"given":"Neil O.","family":"Carragher","sequence":"additional","affiliation":[{"name":"Cancer Research UK Scotland Centre, Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh EH4 2XU, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidushi S.","family":"Neergheen","sequence":"additional","affiliation":[{"name":"Biopharmaceutical Unit, Center for Biomedical and Biomaterials Research (CBBR), University of Mauritius, Reduit 80837, Mauritius"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,21]]},"reference":[{"key":"ref_1","unstructured":"(2026, January 26). 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