{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T13:22:38Z","timestamp":1787664158905,"version":"build-2736575974"},"reference-count":22,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Key-Area Research and Development Program of Guangdong Province","award":["2023B1111050008"],"award-info":[{"award-number":["2023B1111050008"]}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2024A1515011051"],"award-info":[{"award-number":["2024A1515011051"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mar. Drugs","Marine Drugs"],"abstract":"<jats:p>New prenylated isoindolinone alkaloids, aspernidines C-E (1\u20133), a new diketopiperazine alkaloid, protubonine C (4), and new polyketides, (\u00b1)-asperisocoumarin J and asperisocoumarin K (5 and 6), were isolated from the mangrove-derived fungus Aspergillus sp. SCSIO 41440, together with six known compounds (7\u201312). Comprehensive NMR and mass spectrometric analysis, single-crystal X-ray diffraction, and calculated electronic circular dichroism (ECD) were employed for the structural elucidation and stereochemical assignment of these compounds. All compounds were evaluated for their acetylcholinesterase (AChE) inhibitory activity. Compound 10 exhibited potent AChE inhibition with an IC50 value of 3.16 \u00b1 1.16 \u03bcM. Molecular docking analysis further revealed that 10 binds strongly to the AChE active site (PDB: 4EY7). These findings suggest that compound 10 represents a candidate scaffold for further investigation as an AChE inhibitor.<\/jats:p>","DOI":"10.3390\/md24090297","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T12:57:17Z","timestamp":1787662637000},"page":"297","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["New Prenylated Isoindolinone Alkaloids and Polyketides from the Mangrove-Derived Fungus Aspergillus sp. SCSIO 41440"],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-6712-1881","authenticated-orcid":false,"given":"Chun","family":"Yang","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Chen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Tropical Oceanography\/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifei","family":"Xiong","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Cai","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Tropical Oceanography\/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmei","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Chemistry, South China Normal University, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingling","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8327-3108","authenticated-orcid":false,"given":"Yonghong","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Tropical Oceanography\/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9601-4869","authenticated-orcid":false,"given":"Xuefeng","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Tropical Oceanography\/Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China"},{"name":"University of Chinese Academy of Sciences, Beijing 100049, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4799-1345","authenticated-orcid":false,"given":"Huaming","family":"Tao","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"ref_1","first-page":"1025","article-title":"\u201cMarine Rule\u201d: Discovery of marine natural small molecule drug leads in China in the past decade","volume":"24","author":"Chen","year":"2026","journal-title":"Chin. 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