{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T09:07:21Z","timestamp":1789117641405,"version":"build-2803163510"},"reference-count":38,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Academia Collaboration Project of Tajen University","award":["114013"],"award-info":[{"award-number":["114013"]}]},{"award":["114013"],"award-info":[{"award-number":["114013"]}],"id":[{"id":"https:\/\/ror.org\/01fvf0d84","id-type":"ROR","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mar. Drugs","Marine Drugs"],"abstract":"<jats:p>Amyloid-\u03b2 oligomers (A\u03b2Os) induce oxidative and genomic stress that may promote neuronal senescence-like alterations in Alzheimer\u2019s disease. Dieckol, a brown algal phlorotannin, has antioxidant and neuroprotective properties, but its effects on A\u03b2O-induced senescence-like stress remain unclear. Differentiated SH-SY5Y cells were pretreated with dieckol (10\u201350 \u03bcmol\/L) or the receptor for advanced glycation end products (RAGE) antagonist azeliragon (100 \u03bcmol\/L) for 24 h, followed by A\u03b2O (20 \u03bcmol\/L) exposure for 24 h. Dieckol concentration-dependently preserved cell viability, as indirectly assessed by the MTT assay and reduced mitochondrial superoxide accumulation. Dieckol also decreased senescence-associated \u03b2-galactosidase positivity, H3K9me2\/3-associated chromatin remodeling, and interleukin-1\u03b2, interleukin-6, and tumor necrosis factor-\u03b1 secretion while partially restoring telomerase activity. This restoration was consistent with improved cellular stress resilience in the differentiated neuron-like model. Furthermore, dieckol reduced 8-hydroxy-2\u2032-deoxyguanosine and \u03b3-H2AX accumulation and attenuated ATM\u2013Chk2\u2013p53 DNA damage response signaling. Azeliragon elicited broadly similar responses; however, these similarities do not establish RAGE dependence or a shared mechanism of action. Collectively, dieckol concurrently attenuated mitochondrial oxidative stress, DNA damage response signaling, and senescence-associated alterations. Although these parallel effects support a possible relationship among these processes, their causal and temporal relationships remain to be established.<\/jats:p>","DOI":"10.3390\/md24090320","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T08:17:42Z","timestamp":1789114662000},"page":"320","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Brown Algal Phlorotannin Dieckol Attenuates Amyloid-\u03b2 Oligomer-Induced Oxidative DNA Damage and Senescence-like Stress in Human Neuron-like Cells"],"prefix":"10.3390","volume":"24","author":[{"given":"Yu-Ru","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Pet Care and Grooming, College of Pharmacy and Health Care, Tajen University, Pingtung County 90741, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"}]},{"given":"Mei Chou","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Master Program, College of Pharmacy and Health Care, Tajen University, Pingtung County 90741, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"}]},{"given":"Yu-Shun","family":"Tzeng","sequence":"additional","affiliation":[{"name":"Department of Medicine, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"methodology","vocabulary":"credit"},{"role":"investigation","vocabulary":"credit"}]},{"given":"I-Min","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy and Master Program, College of Pharmacy and Health Care, Tajen University, Pingtung County 90741, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"conceptualization","vocabulary":"credit"},{"role":"writing-original-draft","vocabulary":"credit"},{"role":"project-administration","vocabulary":"credit"},{"role":"funding-acquisition","vocabulary":"credit"},{"role":"resources","vocabulary":"credit"},{"role":"supervision","vocabulary":"credit"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1124\/pharmrev.122.000622","article-title":"Cellular senescence: From mechanisms to current biomarkers and senotherapies","volume":"75","author":"Lucas","year":"2023","journal-title":"Pharmacol. 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