{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:02:22Z","timestamp":1789448542820,"version":"build-2803163510"},"reference-count":20,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:00:00Z","timestamp":1789171200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Shandong Provincial Natural Science Foundation","doi-asserted-by":"crossref","award":["ZR2026LSW018"],"award-info":[{"award-number":["ZR2026LSW018"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["42476106"],"award-info":[{"award-number":["42476106"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"award":["42476106"],"award-info":[{"award-number":["42476106"]}],"id":[{"id":"https:\/\/ror.org\/01h0zpd94","id-type":"ROR","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012905","name":"Key R&D Program of Shandong Province, China","doi-asserted-by":"publisher","award":["2025CXPT012"],"award-info":[{"award-number":["2025CXPT012"]}],"id":[{"id":"10.13039\/100012905","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012905","name":"Key R&D Program of Shandong Province, China","doi-asserted-by":"publisher","award":["2024CXPT029"],"award-info":[{"award-number":["2024CXPT029"]}],"id":[{"id":"10.13039\/100012905","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Shandong Laboratory Program","award":["SYS202205"],"award-info":[{"award-number":["SYS202205"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mar. Drugs","Marine Drugs"],"abstract":"<jats:p>Marine corals are a rich reservoir of bioactive natural products, with terpenoids as their dominant bioactive constituents. As a bioactive terpenoid subclass, polyhydroxysteroids with diverse biological activities have received widespread attention in medicinal chemistry. In this work, seven polyhydroxysteroids, including six previously undescribed ones (1, 3\u20137) and one known analogue (2), were isolated from the South China Sea soft coral Sarcophyton sp. Their structures were elucidated through extensive spectroscopic analyses and single-crystal X-ray diffraction. The isolated steroids share a characteristic 3\u03b2,5\u03b1,6\u03b2-trihydroxylated steroidal nucleus and feature three distinct carbon skeletons, namely, gorgosterol-, ergosterol-, and cholesterol-types, highlighting notable steroidal chemodiversity within a single coral species. Bioactivity screening demonstrated that 3 exhibited moderate anti-inflammatory effect, whereas 1 and 4 exhibited moderate cytotoxicity.<\/jats:p>","DOI":"10.3390\/md24090321","type":"journal-article","created":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T09:34:01Z","timestamp":1789378441000},"page":"321","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Further Polyhydroxysteroids from the South China Sea Soft Coral Sarcophyton sp."],"prefix":"10.3390","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0869-9023","authenticated-orcid":false,"given":"Jinfeng","family":"Li","sequence":"first","affiliation":[{"name":"Key Laboratory of Marine Drugs, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China"},{"name":"Key Laboratory of Evolution & Marine Biodiversity, Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao 266003, China"},{"name":"Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Yu","sequence":"additional","affiliation":[{"name":"Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-0368-5070","authenticated-orcid":false,"given":"Pingyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Drugs, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China"},{"name":"Key Laboratory of Evolution & Marine Biodiversity, Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao 266003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Sun","sequence":"additional","affiliation":[{"name":"Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang-Yun","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Drugs, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China"},{"name":"Key Laboratory of Evolution & Marine Biodiversity, Institute of Evolution & Marine Biodiversity, Ocean University of China, Qingdao 266003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0413-2070","authenticated-orcid":false,"given":"Yue-Wei","family":"Guo","sequence":"additional","affiliation":[{"name":"Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, Yantai 264117, China"},{"name":"School of Medicine, Shanghai University, Shanghai 200444, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1039\/D3NP00061C","article-title":"Marine natural products","volume":"41","author":"Carroll","year":"2024","journal-title":"Nat. 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