{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T22:25:05Z","timestamp":1785018305546,"version":"3.55.0"},"reference-count":61,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2009,11,26]],"date-time":"2009-11-26T00:00:00Z","timestamp":1259193600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>The antinociceptive and anti-inflammatory activity of caulerpin was investigated. This bisindole alkaloid was isolated from the lipoid extract of Caulerpa racemosa and its structure was identified by spectroscopic methods, including IR and NMR techniques. The pharmacological assays used were the writhing and the hot plate tests, the formalin-induced pain, the capsaicin-induced ear edema and the carrageenaninduced peritonitis. Caulerpin was given orally at a concentration of 100 \u03bcmol\/kg. In the abdominal constriction test caulerpin showed reduction in the acetic acid-induced nociception at 0.0945 \u03bcmol (0.0103\u20131.0984) and for dypirone it was 0.0426 \u03bcmol (0.0092\u20130.1972). In the hot plate test in vivo the inhibition of nociception by caulerpin (100 \u03bcmol\/kg, p.o.) was also favorable. This result suggests that this compound exhibits a central activity, without changing the motor activity (seen in the rotarod test). Caulerpin (100 \u03bcmol\/kg, p.o.) reduced the formalin effects in both phases by 35.4% and 45.6%, respectively. The possible anti-inflammatory activity observed in the second phase in the formalin test of caulerpin (100 \u03bcmol\/kg, p.o.) was confirmed on the capsaicin-induced ear edema model, where an inhibition of 55.8% was presented. Indeed, it was also observed in the carrageenan-induced peritonitis that caulerpin (100 \u03bcmol\/kg, p.o.) exhibited anti-inflammatory activity, reducing significantly the number of recruit cells by 48.3%. Pharmacological studies are continuing in order to characterize the mechanism(s) responsible for the antinociceptive and anti-inflammatory actions and also to identify other active principles present in Caulerpa racemosa.<\/jats:p>","DOI":"10.3390\/md7040689","type":"journal-article","created":{"date-parts":[[2009,11,28]],"date-time":"2009-11-28T06:03:28Z","timestamp":1259388208000},"page":"689-704","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":140,"title":["The Antinociceptive and Anti-Inflammatory Activities of Caulerpin, a Bisindole Alkaloid Isolated from Seaweeds of the Genus Caulerpa"],"prefix":"10.3390","volume":"7","author":[{"given":"\u00c9verton Ten\u00f3rio","family":"De Souza","sequence":"first","affiliation":[{"name":"LaFI-Laborat\u00f3rio de Farmacologia e Imunidade, Instituto de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade, Universidade Federal de Alagoas, Macei\u00f3, AL, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daysianne","family":"Pereira de Lira","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Tecnologia Farmac\u00eautica, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Cavalcanti de Queiroz","sequence":"additional","affiliation":[{"name":"LaFI-Laborat\u00f3rio de Farmacologia e Imunidade, Instituto de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade, Universidade Federal de Alagoas, Macei\u00f3, AL, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogo Jos\u00e9","family":"Costa da Silva","sequence":"additional","affiliation":[{"name":"LaFI-Laborat\u00f3rio de Farmacologia e Imunidade, Instituto de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade, Universidade Federal de Alagoas, Macei\u00f3, AL, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anansa","family":"Bezerra de Aquino","sequence":"additional","affiliation":[{"name":"LaFI-Laborat\u00f3rio de Farmacologia e Imunidade, Instituto de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade, Universidade Federal de Alagoas, Macei\u00f3, AL, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliane A.","family":"Campessato Mella","sequence":"additional","affiliation":[{"name":"LaFI-Laborat\u00f3rio de Farmacologia e Imunidade, Instituto de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade, Universidade Federal de Alagoas, Macei\u00f3, AL, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vitor","family":"Prates Lorenzo","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Tecnologia Farmac\u00eautica, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George Emmanuel C.","family":"De Miranda","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Algas Marinhas-LAM, Departamento de Sistem\u00e1tica e Ecologia, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Xavier","family":"De Ara\u00fajo-J\u00fanior","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Pesquisa em Recursos Naturais, Instituto de Qu\u00edmica e Biotecnologia, Universidade Federal de Alagoas, Macei\u00f3, AL, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C\u00e9lia","family":"De Oliveira Chaves","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Tecnologia Farmac\u00eautica, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Maria","family":"Barbosa-Filho","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Tecnologia Farmac\u00eautica, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petr\u00f4nio","family":"Filgueiras de Athayde-Filho","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Tecnologia Farmac\u00eautica, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1rbara Viviana","family":"De Oliveira Santos","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Tecnologia Farmac\u00eautica, Universidade Federal da Para\u00edba, Jo\u00e3o Pessoa, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magna Suzana","family":"Alexandre-Moreira","sequence":"additional","affiliation":[{"name":"LaFI-Laborat\u00f3rio de Farmacologia e Imunidade, Instituto de Ci\u00eancias Biol\u00f3gicas e da Sa\u00fade, Universidade Federal de Alagoas, Macei\u00f3, AL, 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