{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T11:26:32Z","timestamp":1792495592265,"version":"4.5.0"},"reference-count":188,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2011,2,8]],"date-time":"2011-02-08T00:00:00Z","timestamp":1297123200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Sulfated polysaccharides and their lower molecular weight oligosaccharide derivatives from marine macroalgae have been shown to possess a variety of biological activities. The present paper will review the recent progress in research on the structural chemistry and the bioactivities of these marine algal biomaterials. In particular, it will provide an update on the structural chemistry of the major sulfated polysaccharides synthesized by seaweeds including the galactans (e.g., agarans and carrageenans), ulvans, and fucans. It will then review the recent findings on the anticoagulant\/antithrombotic, antiviral, immuno-inflammatory, antilipidemic and antioxidant activities of sulfated polysaccharides and their potential for therapeutic application.<\/jats:p>","DOI":"10.3390\/md9020196","type":"journal-article","created":{"date-parts":[[2011,2,8]],"date-time":"2011-02-08T11:09:56Z","timestamp":1297163396000},"page":"196-223","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":995,"title":["Chemical Structures and Bioactivities of Sulfated Polysaccharides from Marine Algae"],"prefix":"10.3390","volume":"9","author":[{"given":"Guangling","family":"Jiao","sequence":"first","affiliation":[{"name":"National Research Council Canada, Institute for Marine Biosciences, Halifax, NS, B3H 3Z1, Canada"},{"name":"Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong 266003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6372-9750","authenticated-orcid":false,"given":"Guangli","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Drugs, Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, Shandong 266003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junzeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"National Research Council Canada, Institute for Nutrisciences and Health, Charlottetown, PEI, C1A 4P3, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. Stephen","family":"Ewart","sequence":"additional","affiliation":[{"name":"National Research Council Canada, Institute for Marine Biosciences, Halifax, NS, B3H 3Z1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2011,2,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1002\/biot.200700054","article-title":"Structure, biological activity, and enzymatic transformation of fucoidans from the brown seaweeds","volume":"3","author":"Kusaykin","year":"2008","journal-title":"Biotechnol J"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1023\/A:1011142124213","article-title":"Developments on gelling algal galactans, their structure and physico-chemistry","volume":"13","author":"Lahaye","year":"2001","journal-title":"J Appl Phycol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1021\/bm061185q","article-title":"Structure and functional properties of ulvan, a polysaccharide from green seaweeds","volume":"8","author":"Lahaye","year":"2007","journal-title":"Biomacromolecules"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.3390\/molecules13081671","article-title":"Fucoidan: structure and bioactivity","volume":"13","author":"Li","year":"2008","journal-title":"Molecules"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10719-009-9251-z","article-title":"Structural and functional insights into sulfated galactans: A systematic review","volume":"27","author":"Pomin","year":"2010","journal-title":"Glycoconj J"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1093\/glycob\/cwn085","article-title":"Structure, biology, evolution, and medical importance of sulfated fucans and galactans","volume":"18","author":"Pomin","year":"2008","journal-title":"Glycobiology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1070\/RC2009v078n08ABEH004063","article-title":"Fucoidans-Sulfated polysaccharides of brown algae","volume":"78","author":"Usov","year":"2009","journal-title":"Russ Chem Rev"},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Wijesekara, I, Pangestuti, R, and Kim, S-K (2010). 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