{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:40:21Z","timestamp":1789393221856,"version":"build-2803163510"},"reference-count":10,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2011,3,17]],"date-time":"2011-03-17T00:00:00Z","timestamp":1300320000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Marine sponge Hymeniacidon sp. was collected from coastal waters of the East China Sea to isolate symbiotic microorganisms. The resulting sponge-associated actinomycete, Streptomyces carnosus strain AZS17, was cultivated in a 20 L volume of medium for production of bioactive secondary metabolites. Bioassay-guided isolation and purification by varied chromatographic methods yielded two new compounds of kijanimicin derivatives, AS7-2 and AS9-12. Their structures were elucidated by spectroscopy and comparison with literatures. Results showed these two compounds were structurally similar to the previously reported compounds lobophorin A and B, yet differed in specific bond forms, stereochemistry and optical activities. The two novel compounds were named lobophorin C and D. In vitro cytotoxicity investigation by MTT assay indicated their selective activities. Lobophorin C displayed potent cytotoxic activity against the human liver cancer cell line 7402, while lobophorin D showed significant inhibitory effect on human breast cancer cells MDA-MB 435.<\/jats:p>","DOI":"10.3390\/md9030359","type":"journal-article","created":{"date-parts":[[2011,3,17]],"date-time":"2011-03-17T12:53:34Z","timestamp":1300366414000},"page":"359-368","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":72,"title":["Lobophorin C and D, New Kijanimicin Derivatives from a Marine Sponge-Associated Actinomycetal Strain AZS17"],"prefix":"10.3390","volume":"9","author":[{"given":"Rong-Bian","family":"Wei","sequence":"first","affiliation":[{"name":"College of Marine Science, Zhejiang Ocean University, Zhoushan 316004, China"},{"name":"Marine Drugs Research Centre, China Pharmaceutical University, Nanjing 210018, China"},{"name":"Open Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Xi","sequence":"additional","affiliation":[{"name":"Marine Drugs Research Centre, China Pharmaceutical University, Nanjing 210018, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Marine Science, Zhejiang Ocean University, Zhoushan 316004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu-Chao","family":"Li","sequence":"additional","affiliation":[{"name":"Open Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Cheng","family":"Lin","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Qin","sequence":"additional","affiliation":[{"name":"Open Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2011,3,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"4431","DOI":"10.1128\/AEM.68.9.4431-4440.2002","article-title":"Molecular evidence for a uniform microbial community in sponges from different oceans","volume":"68","author":"Hentschel","year":"2002","journal-title":"Appl Environ 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