{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T21:19:35Z","timestamp":1790716775861,"version":"4.1.0"},"reference-count":138,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2011,11,10]],"date-time":"2011-11-10T00:00:00Z","timestamp":1320883200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Marine Drugs"],"abstract":"<jats:p>Aplysina is the best representative genus of the family Aplysinidae. Halogenated substances are its main class of metabolites. These substances contribute greatly to the chemotaxonomy and characterization of the sponges belonging to this genus. Due to their pharmacological activities, these alkaloids are of special interest. The chemistry of halogenated substances and of the alkaloids has long been extensively studied in terrestrial organisms, while the number of marine organisms studied has just started to increase in the last decades. This review describes 101 halogenated substances from 14 species of Aplysina from different parts of the world. These substances can be divided into the following classes: bromotyramines (A), cavernicolins (B), hydroverongiaquinols (C), bromotyrosineketals (D), bromotyrosine lactone derivatives (E), oxazolidones (F), spiroisoxazolines (G), verongiabenzenoids (H), verongiaquinols (I), and dibromocyclohexadienes (J). A compilation of their 13C NMR data is also part of the review. For this purpose 138 references were consulted.<\/jats:p>","DOI":"10.3390\/md9112316","type":"journal-article","created":{"date-parts":[[2011,11,10]],"date-time":"2011-11-10T11:10:58Z","timestamp":1320923458000},"page":"2316-2368","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Brominated Compounds from Marine Sponges of the Genus Aplysina and a Compilation of Their 13C NMR Spectral Data"],"prefix":"10.3390","volume":"9","author":[{"given":"Narlize Silva","family":"Lira","sequence":"first","affiliation":[{"name":"Laboratory of Pharmaceutical Technology, Federal University of Paraiba, Joao Pessoa 58051-900, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Carneiro","family":"Montes","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Technology, Federal University of Paraiba, Joao Pessoa 58051-900, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josean Fechine","family":"Tavares","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Technology, Federal University of Paraiba, Joao Pessoa 58051-900, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Sobral da","family":"Silva","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Technology, Federal University of Paraiba, Joao Pessoa 58051-900, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emidio V. L. da","family":"Cunha","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, State University of Paraiba, Campina Grande 58100-000, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petronio Filgueiras de","family":"Athayde-Filho","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Technology, Federal University of Paraiba, Joao Pessoa 58051-900, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Cezar","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Technology, Federal University of Paraiba, Joao Pessoa 58051-900, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celidarque da Silva","family":"Dias","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Technology, Federal University of Paraiba, Joao Pessoa 58051-900, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Maria","family":"Barbosa-Filho","sequence":"additional","affiliation":[{"name":"Laboratory of Pharmaceutical Technology, Federal University of Paraiba, Joao Pessoa 58051-900, PB, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2011,11,10]]},"reference":[{"key":"ref_1","unstructured":"Available online: http:\/\/www.britannica.com."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"4431","DOI":"10.1128\/AEM.68.9.4431-4440.2002","article-title":"Molecular evidence for a uniform microbial community in sponges from different oceans","volume":"68","author":"Hentschel","year":"2002","journal-title":"Appl. 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