{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:26:28Z","timestamp":1772252788072,"version":"3.50.1"},"reference-count":30,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T00:00:00Z","timestamp":1532908800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and objectives: The aim of present study was to compare the treatment results of daily cisplatin (CDDP), weekly docetaxel (DOC) intra-arterial infusion chemotherapy combined with radiotherapy (DIACRT) regimen and weekly CDDP intra-arterial infusion chemotherapy combined with radiotherapy (WIACRT) for patients with tongue cancer. Materials and Methods: Between January 2007 and December 2016, a total of 11 patients treated with WIACRT and 45 patients treated with DIACRT were enrolled in the present study. In the DIACRT group, 25 patients had late T2, and 20 patients had T3. A total of nine patients had late T2 and two had T3 in WIACRT (p = NS). In DIACRT, the treatment schedule consisted of intra-arterial chemotherapy (DOC, total 60 mg\/m2; CDDP, total 150 mg\/m2) and daily concurrent radiotherapy (RT) (total, 60 Gy). In WIACRT, the treatment schedule consisted of intra-arterial chemotherapy (CDDP, total 360 mg\/m2) and daily concurrent RT (total, 60 Gy). Results: The median follow-up periods for DIACRT and WIACRT were 61 and 66 months, respectively. The five-year local control (LC) and overall survival (OS) rate were 94.5% and 89.6% for the DIACRT group, and 60.6% and 63.6% for the WIACRT group, respectively. The LC rate and OS of the DIACRT group were significantly higher than those of the WIACRT group. As regards toxicities, no treatment-related deaths were observed during the follow-up periods in both groups. Conclusions: DIACRT was found to be feasible and effective for patients with tongue cancer and could become a new treatment modality.<\/jats:p>","DOI":"10.3390\/medicina54040052","type":"journal-article","created":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T11:55:08Z","timestamp":1532951708000},"page":"52","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Daily Cisplatin and Weekly Docetaxel versus Weekly Cisplatin Intra-Arterial Chemoradiotherapy for Late T2-3 Tongue Cancer: A Pilot and Feasibility Trial"],"prefix":"10.3390","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5241-8669","authenticated-orcid":false,"given":"Yuichiro","family":"Hayashi","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Yokohama City University 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhei","family":"Minamiyama","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Yokohama City University 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Ohya","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Yokohama City University 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Iida","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Yokohama City University 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshinori","family":"Iwai","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Yokohama City University 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Koizumi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Yokohama City University 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Senri","family":"Oguri","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Yokohama City University 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Hirota","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Yokohama City University 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitomu","family":"Kioi","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Yokohama City University 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaharu","family":"Hata","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Graduate School of Medicine, Yokohama City University 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masataka","family":"Taguri","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Graduate School of Medicine, Yokohama City University 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Mitsudo","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Graduate School of Medicine, Yokohama City University 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,7,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1002\/hed.2880140505","article-title":"Rapid superselective high-dose cisplatin infusion for advanced head and neck malignancies","volume":"14","author":"Robbins","year":"1992","journal-title":"Head Neck"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1200\/JCO.2005.03.168","article-title":"Supradose intra-arterial cisplatin and concurrent radiation therapy for the treatment of stage IV head and neck squamous cell carcinoma is feasible and efficacious in a multi-institutional setting: Results of Radiation Therapy Oncology Group Trial 9615","volume":"23","author":"Robbins","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/00005537-200403000-00004","article-title":"Factors predictive of local disease control after intra-arterial concomitant chemoradiation (RADPLAT)","volume":"114","author":"Robbins","year":"2004","journal-title":"Laryngoscope"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1200\/JCO.1994.12.10.2113","article-title":"Phase I study of highly selective supradose cisplatin infusions for advanced head and neck cancer","volume":"12","author":"Robbins","year":"1994","journal-title":"J. Clin. Oncol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/S1368-8375(98)00018-9","article-title":"New superselective intra-arterial infusion via superficial temporal artery for cancer of the tongue and tumour tissue platinum concentration after carboplatin (CBDCA) infusion","volume":"34","author":"Tohnai","year":"1998","journal-title":"Oral Oncol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.radonc.2014.03.005","article-title":"Retrograde superselective intra-arterial chemotherapy and daily concurrent radiotherapy for stage III and IV oral cancer: Analysis of therapeutic results in 112 cases","volume":"111","author":"Mitsudo","year":"2014","journal-title":"Radiother. Oncol."},{"key":"ref_7","unstructured":"Breslow, N.E., Day, N.E., and International Agency for Research on Cancer (1980). Statistical Methods in Cancer Research. Vol. 1. The Analysis of Case-Control Studies, IARC Scientific Publication."},{"key":"ref_8","first-page":"205","article-title":"Secure Surgical Method for Catheter Placement via the Occipital Artery to Achieve Retrograde Superselective Intra-Arterial Chemotherapy for Advanced Oral Cancer: Alternative to Approach via the Superficial Temporal Artery. Indian","volume":"66","author":"Iwai","year":"2014","journal-title":"J. Otolaryngol. Head Neck Surg."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/BF00873957","article-title":"Differential cytotoxic effects of docetaxel in a range of mammalian tumor cell lines and certain drug resistant sublines in vitro","volume":"12","author":"Hill","year":"1994","journal-title":"Investig. New Drugs"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0167-8140(97)00048-0","article-title":"Radiation therapy alone or with concurrent low-dose daily either cisplatin or carboplatin in locally advanced unresectable squamous cell carcinoma of the head and neck: A prospective randomized trial","volume":"43","author":"Jeremic","year":"1997","journal-title":"Radiother. Oncol."},{"key":"ref_11","first-page":"4135","article-title":"Concurrent chemoradiotherapy with cisplatin and docetaxel for advanced head and neck cancer. A phase I. study","volume":"24","author":"Inohara","year":"2004","journal-title":"Anticancer Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.tripleo.2007.07.031","article-title":"A new method of selective intra-arterial infusion therapy via the superficial temporal artery for head and neck cancer","volume":"105","author":"Fuwa","year":"2008","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1200\/JCO.2003.01.008","article-title":"An intergroup phase III comparison of standard radiation therapy and two schedules of concurrent chemoradiotherapy in patients with unresectable squamous cell head and neck cancer","volume":"21","author":"Adelstein","year":"2003","journal-title":"J. Clin. Oncol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"3582","DOI":"10.1200\/JCO.2007.14.8841","article-title":"Factors associated with severe late toxicity after concurrent chemoradiation for locally advanced head and neck cancer: An RTOG analysis","volume":"26","author":"Machtay","year":"2008","journal-title":"J. Clin. Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1093\/jjco\/hyr086","article-title":"Concomitant weekly cisplatin and radiotherapy for head and neck cancer","volume":"41","author":"Homma","year":"2011","journal-title":"Jpn. J. Clin. Oncol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1093\/annonc\/mdq219","article-title":"Concomitant chemoradiation versus radical radiotherapy in advanced squamous cell carcinoma of oropharynx and nasopharynx using weekly cisplatin: A phase II randomized trial","volume":"21","author":"Sharma","year":"2010","journal-title":"Ann. Oncol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"4533","DOI":"10.1002\/cncr.25189","article-title":"Concomitant weekly cisplatin and altered fractionation radiotherapy in locally advanced head and neck cancer","volume":"116","author":"Newlin","year":"2010","journal-title":"Cancer"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1002\/hed.21224","article-title":"Comprehensive IMRT plus weekly cisplatin for advanced head and neck cancer: The University of Wisconsin experience","volume":"32","author":"Traynor","year":"2010","journal-title":"Head Neck"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4103\/2278-330X.181647","article-title":"Long term results of comparison of concurrent low-dose daily cisplatin versus the standard weekly cisplatin with six fractions per week radiotherapy in locally advanced head neck cancer","volume":"5","author":"Gupta","year":"2016","journal-title":"South Asian J. Cancer"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1007\/s00405-016-4326-5","article-title":"Comparing two lower-dose cisplatin programs for radio-chemotherapy of locally advanced head-and-neck cancers","volume":"274","author":"Rades","year":"2017","journal-title":"Eur. Arch. Oto-Rhino-Laryngol."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1111\/j.1349-7006.2004.tb03329.x","article-title":"Docetaxel enhances the cytotoxicity of cisplatin to gastric cells by modification of intracellular platinum metabolism","volume":"95","author":"Maeda","year":"2004","journal-title":"Cancer Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.clon.2003.07.003","article-title":"Efficacy of intra-arterial infusion therapy using a combination of cisplatin and docetaxel for recurrent head and neck cancers compared with cisplatin alone","volume":"15","author":"Yabuuchi","year":"2003","journal-title":"Clin. Oncol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.oraloncology.2008.05.017","article-title":"Current concepts in management of oral cancer-surgery","volume":"45","author":"Shah","year":"2009","journal-title":"Oral Oncol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1055\/s-0036-1594020","article-title":"Primary Concurrent Chemoradiation in Head and Neck Cancers with Weekly Cisplatin Chemotherapy: Analysis of Compliance, Toxicity and Survival","volume":"21","author":"Iqbal","year":"2017","journal-title":"Int. Arch. Otorhinolaryngol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1038\/sj.bjc.6604272","article-title":"Intra-arterial chemoradiotherapy for locally advanced oral cavity cancer: Analysis of therapeutic results in 134 cases","volume":"98","author":"Fuwa","year":"2008","journal-title":"Br. J. Cancer"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.ijom.2015.03.009","article-title":"Intra-arterial chemoradiation therapy with weekly low-dose cisplatin for squamous cell carcinoma of the maxillary sinus","volume":"44","author":"Kaneko","year":"2015","journal-title":"Int. J. Oral Maxillofac. Surg."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.ijrobp.2008.02.021","article-title":"Arterial Chemoradiotherapy for Locally Advanced Tongue Cancer: Analysis of Retrospective Study of Therapeutic Results in 88 Patients","volume":"72","author":"Fuwa","year":"2008","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s00432-015-2069-0","article-title":"Treatment results of alternating chemoradiotherapy followed by proton beam therapy boost combined with intra-arterial infusion chemotherapy for stage III-IVB tongue cancer","volume":"142","author":"Takayama","year":"2016","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.oraloncology.2003.09.019","article-title":"Recurrent carcinoma of the head and neck: Treatment strategies and survival analysis in a 20-year period","volume":"40","author":"Eckardt","year":"2004","journal-title":"Oral Oncol."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.oraloncology.2018.02.002","article-title":"Chemoradiotherapy using retrograde superselective intra-arterial infusion for tongue cancer: Analysis of therapeutic results in 118 cases","volume":"79","author":"Mitsudo","year":"2018","journal-title":"Oral Oncol."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/54\/4\/52\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T15:15:13Z","timestamp":1760195713000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/54\/4\/52"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,30]]},"references-count":30,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,9]]}},"alternative-id":["medicina54040052"],"URL":"https:\/\/doi.org\/10.3390\/medicina54040052","relation":{"has-preprint":[{"id-type":"doi","id":"10.20944\/preprints201805.0110.v1","asserted-by":"object"}]},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,30]]}}}