{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T17:08:15Z","timestamp":1787504895798,"version":"build-2736575974"},"reference-count":128,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2018,10,11]],"date-time":"2018-10-11T00:00:00Z","timestamp":1539216000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Cardiac insulin signaling can be impaired due to the altered fatty acid metabolism to induce insulin resistance. In diabetes and insulin resistance, the metabolic, structural and ultimately functional alterations in the heart and vasculature culminate in diabetic cardiomyopathy, coronary artery disease, ischemia and eventually heart failure. Glucolipotoxicity describes the combined, often synergistic, adverse effects of elevated glucose and free fatty acid concentrations on heart structure, function, and survival. The quality of fatty acid shapes the cardiac structure and function, often influencing survival. A healthy fatty acid balance is therefore critical for maintaining cardiac integrity and function.<\/jats:p>","DOI":"10.3390\/medicina54050070","type":"journal-article","created":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T02:58:04Z","timestamp":1539313084000},"page":"70","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Cardiac Glucolipotoxicity and Cardiovascular Outcomes"],"prefix":"10.3390","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6090-3736","authenticated-orcid":false,"given":"Marlon E.","family":"Cerf","sequence":"first","affiliation":[{"name":"Biomedical Research and Innovation Platform, South African Medical Research Council, Tygerberg 7505, South Africa"},{"name":"Division of Medical Physiology, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, University of Stellenbosch, Tygerberg 7505, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,10,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"581","DOI":"10.2337\/diabetes.52.3.581","article-title":"Glucose toxicity in \u03b2-cells: Type 2 diabetes, good radicals gone bad, and the glutathione connection","volume":"52","author":"Robertson","year":"2003","journal-title":"Diabetes"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.jprot.2008.10.002","article-title":"Glucotoxicity and pancreatic proteomics","volume":"71","author":"Brunner","year":"2009","journal-title":"J. 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