{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:58:46Z","timestamp":1792601926348,"version":"4.5.0"},"reference-count":40,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2019,1,12]],"date-time":"2019-01-12T00:00:00Z","timestamp":1547251200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>The current prevalence of pediatric Celiac Disease (CD) is estimated to be around 1% in the general population, worldwide. However, according to the geographic area, a great variability of CD prevalence has been described. Whereas a number of studies are available from Europe, North and South America, Australia, South-West Asia, and North Africa, the knowledge and awareness of CD in large parts of the remaining world areas is definitively poor. In several countries of Central and East Asia, the consumption of wheat is consistent and\/or has significantly increased in recent decades, and CD is supposed to be underdiagnosed in children. In this mini-review, we aimed to summarize the current knowledge about the prevalence of pediatric CD in Central and East Asia, paying attention to the HLA-DQ immunogenetic background as well. Indeed, CD is likely not to be as uncommon as previously or currently thought in countries like Russia, Kazakhstan, and China, in addition to India, where pediatric CD has been clearly showed to be quite prevalent. Therefore, there is an urgent need for population-based studies on the prevalence of CD in those countries, especially in children, in order to increase the awareness of this disease and to improve the diagnostic strategy in these areas.<\/jats:p>","DOI":"10.3390\/medicina55010011","type":"journal-article","created":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T12:20:07Z","timestamp":1547468407000},"page":"11","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Pediatric Celiac Disease in Central and East Asia: Current Knowledge and Prevalence"],"prefix":"10.3390","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6431-9334","authenticated-orcid":false,"given":"Dimitri","family":"Poddighe","sequence":"first","affiliation":[{"name":"Department of Medicine, Nazarbayev University School of Medicine, 010000 Astana, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5127-9599","authenticated-orcid":false,"given":"Marzhan","family":"Rakhimzhanova","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, National Research Center of Mother and Child Health, University Medical Center, 010000 Astana, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yelena","family":"Marchenko","sequence":"additional","affiliation":[{"name":"Center of Laboratory Medicine, Republican Diagnostic Center, University Medical Center, 010000 Astana, Kazakhstan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Catassi","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Universita\u2019 Politecnica delle Marche, 60121 Ancona, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,1,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/S0140-6736(09)60254-3","article-title":"Coeliac disease","volume":"373","author":"Corazza","year":"2009","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1056\/NEJMoa1400697","article-title":"Introduction of gluten, HLA status, and the risk of celiac disease in children","volume":"371","author":"Lionetti","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/pr.2017.307","article-title":"HLA-DQ genetics in children with celiac disease: A meta-analysis suggesting a two-step genetic screening procedure starting with HLA-DQ \u03b2 chains","volume":"83","author":"Capittini","year":"2018","journal-title":"Pediatr Res."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1097\/MPG.0b013e31821a23d0","article-title":"European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease","volume":"54","author":"Husby","year":"2012","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"637187","DOI":"10.1155\/2012\/637187","article-title":"Atypical celiac disease: From recognizing to managing","volume":"2012","author":"Admou","year":"2012","journal-title":"Gastroenterol. Res. Pract."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1007\/s00431-018-3199-6","article-title":"Towards an individual screening strategy for first-degree relatives of celiac patients","volume":"177","author":"Wessels","year":"2018","journal-title":"Eur. J. Pediatr."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1007\/s00431-018-3251-6","article-title":"Individual screening strategy for pediatric celiac disease","volume":"177","author":"Poddighe","year":"2018","journal-title":"Eur. J. Pediatr."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.cgh.2017.06.037","article-title":"Global Prevalence of Celiac Disease: Systematic Review and Meta-analysis","volume":"16","author":"Singh","year":"2018","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1159\/000369518","article-title":"World perspective and celiac disease epidemiology","volume":"33","author":"Catassi","year":"2015","journal-title":"Dig. Dis."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1111\/jgh.13270","article-title":"Prevalence of celiac disease in Asia: A systematic review and meta-analysis","volume":"31","author":"Singh","year":"2016","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1038\/ajg.2015.398","article-title":"Prevalence of Adult Celiac Disease in India: Regional Variations and Associations","volume":"111","author":"Ramakrishna","year":"2016","journal-title":"Am. J. Gastroenterol."},{"key":"ref_12","first-page":"5","article-title":"Epidemiology of celiac disease in iran: A review","volume":"3","author":"Rostami","year":"2011","journal-title":"Middle East J. Dig. Dis."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1034\/j.1399-0039.2000.560606.x","article-title":"Allele frequencies and haplotypic associations defined by allelic DNA typing at HLA class I and class II loci in the Japanese population","volume":"56","author":"Saito","year":"2000","journal-title":"Tissue Antigens"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1111\/j.1440-1746.2009.05932.x","article-title":"Prevalence of celiac disease in the Asia-Pacific region","volume":"24","author":"Cummins","year":"2009","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/s00535-017-1339-9","article-title":"Celiac disease in non-clinical populations of Japan","volume":"53","author":"Fukunaga","year":"2018","journal-title":"J. Gastroenterol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/1751-2980.12587","article-title":"Prevalence of celiac disease in adult Chinese patients with diarrhea-predominant irritable bowel syndrome: A prospective, controlled, cohort study","volume":"19","author":"Kou","year":"2018","journal-title":"J. Dig. Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"e1779","DOI":"10.1097\/MD.0000000000001779","article-title":"Serological Screening for Celiac Disease in Adult Chinese Patients with Diarrhea Predominant Irritable Bowel Syndrome","volume":"94","author":"Wang","year":"2015","journal-title":"Medicine"},{"key":"ref_18","doi-asserted-by":"crossref","unstructured":"Yuan, J., Gao, J., Li, X., Liu, F., Wijmenga, C., Chen, H., and Gilissen, L.J. (2013). The tip of the \u201cceliac iceberg\u201d in China: A systematic review and meta-analysis. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0081151"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1016\/j.cgh.2017.04.025","article-title":"Prevalence of Celiac Disease Autoimmunity Among Adolescents and Young Adults in China","volume":"15","author":"Yuan","year":"2017","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Zhao, Z., Zou, J., Zhao, L., Cheng, Y., Cai, H., Li, M., Liu, E., Yu, L., and Liu, Y. (2016). Celiac Disease Autoimmunity in Patients with Autoimmune Diabetes and Thyroid Disease among Chinese Population. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0157510"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1097\/MPG.0b013e31822a0128","article-title":"Celiac disease in children with diarrhea in 4 cities in China","volume":"53","author":"Wang","year":"2011","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S0198-8859(02)00413-5","article-title":"Pediatric celiac disease in India is associated with multiple DR3-DQ2 haplotypes","volume":"63","author":"Kaur","year":"2002","journal-title":"Hum. Immunol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.cgh.2016.04.032","article-title":"Ethnic Variations in Duodenal Villous Atrophy Consistent with Celiac Disease in the United States","volume":"14","author":"Krigel","year":"2016","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1111\/j.1440-1746.2010.06606.x","article-title":"Prevalence of celiac disease in the northern part of India: A community based study","volume":"26","author":"Makharia","year":"2011","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1399-0039.2008.01083.x","article-title":"Genetic affinities of north and northeastern populations of India: Inference from HLA-based study","volume":"72","author":"Agrawal","year":"2008","journal-title":"Tissue Antigens"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1111\/j.1440-1746.2006.04281.x","article-title":"Prevalence of celiac disease among school children in Punjab, North India","volume":"21","author":"Sood","year":"2006","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_27","first-page":"415","article-title":"Prevalence of celiac disease in north Indian children","volume":"46","author":"Bhattacharya","year":"2009","journal-title":"Indian Pediatr."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1440-1746.2009.06044.x","article-title":"Prevalence, human leukocyte antigen typing and strategy for screening among Asian first-degree relatives of children with celiac disease","volume":"25","author":"Srivastava","year":"2010","journal-title":"J. Gastroenterol. Hepatol."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1007\/s12098-016-2146-7","article-title":"HLA Profile of Celiac Disease among First-Degree Relatives from a Tertiary Care Center in North India","volume":"83","author":"Singla","year":"2016","journal-title":"Indian J. Pediatr."},{"key":"ref_30","first-page":"233","article-title":"Prevalence of celiac disease among siblings of celiac disease patients","volume":"25","author":"Gautam","year":"2006","journal-title":"Indian J. Gastroenterol."},{"key":"ref_31","first-page":"230","article-title":"Celiac disease in India","volume":"26","author":"Yachha","year":"2007","journal-title":"Indian J. Gastroenterol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e011173","DOI":"10.1136\/bmjopen-2016-011173","article-title":"Cross-sectional study of coeliac autoimmunity in a population of Vietnamese children","volume":"6","author":"Zanella","year":"2016","journal-title":"BMJ Open"},{"key":"ref_33","first-page":"82","article-title":"Frequency of HLA-DQB1*0201\/02 and DQB1*0302 alleles and tissue transglutaminase antibody seropositivity in children with type 1 diabetes mellitus","volume":"35","author":"Thammarakcharoen","year":"2017","journal-title":"Asian Pac. J. Allergy Immunol."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Yap, T.W., Chan, W.K., Leow, A.H., Azmi, A.N., Loke, M.F., Vadivelu, J., and Goh, K.L. (2015). Prevalence of serum celiac antibodies in a multiracial Asian population-a first study in the young Asian adult population of Malaysia. PLoS ONE, 10.","DOI":"10.1371\/journal.pone.0121908"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"2314813","DOI":"10.1155\/2017\/2314813","article-title":"Overview of Celiac Disease in Russia: Regional Data and Estimated Prevalence","volume":"2017","author":"Savvateeva","year":"2017","journal-title":"J. Immunol. Res."},{"key":"ref_36","first-page":"44","article-title":"Genetic research of HLA genes I and II class\u2014DRB1, DQA1, DQB1 in patients with celiac disease","volume":"11","author":"Kurtanov","year":"2015","journal-title":"Bull. Hematol."},{"key":"ref_37","first-page":"65","article-title":"The prevalence of polymorphisms of genes HLA DQA1 and DQB1 in patients with type 1 diabetes and celiac disease in the Krasnodar Region","volume":"5","author":"Tlif","year":"2012","journal-title":"Kuban Sci. Med. Bull."},{"key":"ref_38","first-page":"106","article-title":"Clinical, epidemiological and genetic characteristics of celiac disease in children in Kazakhstan","volume":"87","author":"Sharipova","year":"2009","journal-title":"Pediatr. Named G.N. Speransky"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1016\/j.cgh.2018.03.028","article-title":"Comparison of Diagnostic Performance of the IgA Anti-tTG Test vs IgA Anti-Native Gliadin Antibodies Test in Detection of Celiac Disease in the General Population","volume":"16","author":"Verma","year":"2018","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"34","DOI":"10.20534\/ESR-16-3.4-34-36","article-title":"Immunogenetic Profile in children with celiac disease from Uzbek population","volume":"3\u20134","author":"Abduzhabarova","year":"2016","journal-title":"Eur. Sci. Rev."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/55\/1\/11\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:25:28Z","timestamp":1760185528000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/55\/1\/11"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,12]]},"references-count":40,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,1]]}},"alternative-id":["medicina55010011"],"URL":"https:\/\/doi.org\/10.3390\/medicina55010011","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,12]]}}}