{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T23:43:57Z","timestamp":1781221437950,"version":"3.54.1"},"reference-count":28,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T00:00:00Z","timestamp":1547424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and objectives: The quality of life and disease outcomes in bipolar patients, including increased risk of psychiatric hospitalizations and suicide, are adversely affected by the presence of borderline personality disorder (BPD). Our study aims to determine the impact of BPD on the inpatient outcomes of bipolar disorder patients. Methods: We used Nationwide Inpatient Sample from the US hospitals and identified cases with bipolar disorder and comorbid BPD (N = 268,232) and controls with bipolar disorder only (N = 242,379), using the International Classification of Diseases, 9th Revision, and Clinical Modification codes. We used multinomial logistic regression to generate odds ratios (OR) and evaluate inpatient outcomes. Results: The majority of the bipolar patients with BPD were female (84.2%), Caucasian (83.1%) and 18\u201335 years age (53.9%). Significantly longer inpatient stays, higher inpatient charges, and higher prevalence of drug abuse were noted in bipolar patients with BPD. The suicide risk was higher in bipolar patients with BPD (OR = 1.418; 95% CI 1.384\u20131.454; p &lt; 0.001). In addition, utilization of electroconvulsive treatment (ECT) was higher in bipolar patients with comorbid BPD (OR = 1.442; 95% CI 1.373\u20131.515; p &lt; 0.001). Conclusions: The presence of comorbid BPD in bipolar disorder is associated with higher acute inpatient care due to a longer inpatient stay and higher cost during hospitalization, and higher suicide risk, and utilization of ECT. Further studies in the inpatient setting are warranted to develop effective clinical strategies for optimal outcomes and reduction of suicide risk in bipolar patients with BPD.<\/jats:p>","DOI":"10.3390\/medicina55010013","type":"journal-article","created":{"date-parts":[[2019,1,14]],"date-time":"2019-01-14T12:20:07Z","timestamp":1547468407000},"page":"13","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Bipolar Disorder and Comorbid Borderline Personality Disorder: Patient Characteristics and Outcomes in US Hospitals"],"prefix":"10.3390","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2895-9155","authenticated-orcid":false,"given":"Rikinkumar S.","family":"Patel","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Griffin Memorial Hospital, 900 E Main St, Norman, OK 73071, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geetha","family":"Manikkara","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Texas Tech University Health Science Center, Midland, TX 79701, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Chopra","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Allegheny Health Network, 4 Allegheny Center 8th Floor, Pittsburgh, PA 15212, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,1,14]]},"reference":[{"key":"ref_1","unstructured":"(2018, March 05). National Institute of Mental Health-Bipolar Disorder, Available online: https:\/\/www.nimh.nih.gov\/health\/topics\/bipolar-disorder\/index.shtml."},{"key":"ref_2","first-page":"196","article-title":"The International College of Neuropsychopharmacology (CINP) Treatment Guidelines for Bipolar Disorder in Adults (CINP-BD-2017), Part 4: Unmet Needs in the Treatment of Bipolar Disorder and Recommendations for Future Research","volume":"20","author":"Fountoulakis","year":"2017","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1001\/archpsyc.64.5.543","article-title":"Lifetime and 12-month prevalence of bipolar spectrum disorder in the National Comorbidity Survey replication","volume":"64","author":"Merikangas","year":"2007","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref_4","unstructured":"(2018, March 05). National Institute of Mental Health-Borderline Personality Disorder, Available online: https:\/\/www.nimh.nih.gov\/health\/topics\/borderline-personality-disorder\/index.shtml."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s40345-017-0100-x","article-title":"The relationship between self-reported borderline personality features and prospective illness course in bipolar disorder","volume":"5","author":"Riemann","year":"2017","journal-title":"Int. J. Bipolar Disord."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"155","DOI":"10.31887\/DCNS.2013.15.2\/mzimmerman","article-title":"The relationship between borderline personality disorder and bipolar disorder","volume":"15","author":"Zimmerman","year":"2013","journal-title":"Dialogues Clin. Neurosci."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jad.2016.01.040","article-title":"The prevalence and predictors of bipolar and borderline personality disorders comorbidity: Systematic review and meta-analysis","volume":"195","author":"Fornaro","year":"2016","journal-title":"J. Affect. Disord."},{"key":"ref_8","doi-asserted-by":"crossref","unstructured":"Riemann, G., Weisscher, N., Goossens, P.J., Draijer, N., Apenhorst-Hol, M., and Kupka, R.W. (2014). The addition of STEPPS in the treatment of patients with bipolar disorder and comorbid borderline personality features: A protocol for a randomized controlled trial. BMC Psychiatry, 14.","DOI":"10.1186\/1471-244X-14-172"},{"key":"ref_9","first-page":"386","article-title":"Borderline personality disorder and bipolar disorder comorbidity in suicidal patients: Diagnostic and therapeutic challenges","volume":"21","year":"2009","journal-title":"Psychiatr. Danub."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1080\/10673220490472346","article-title":"Is borderline personality disorder part of the bipolar spectrum?","volume":"12","author":"Smith","year":"2004","journal-title":"Harv. Rev. Psychiatry"},{"key":"ref_11","first-page":"301","article-title":"Borderline personality disorder: Bipolarity, mood stabilizers and atypical antipsychotics in treatment","volume":"4","author":"Belli","year":"2012","journal-title":"J. Clin. Med. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1007\/s11920-007-0008-8","article-title":"The role of functional neuroimaging in exploring the overlap between borderline personality disorder and bipolar disorder","volume":"9","author":"Sripada","year":"2007","journal-title":"Curr. Psychiatry Rep."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s11126-012-9214-6","article-title":"The association of bipolar spectrum disorders and borderline personality disorder","volume":"83","author":"Antoniadis","year":"2012","journal-title":"Psychiatr. Q."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1177\/0004867412445528","article-title":"Bordering on bipolar: The overlap between borderline personality and bipolarity","volume":"46","author":"Coulston","year":"2012","journal-title":"Aust. N. Z. J. Psychiatry"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1080\/10673220490472373","article-title":"Borderline or bipolar? Distinguishing borderline personality disorder from bipolar spectrum disorders","volume":"12","author":"Paris","year":"2004","journal-title":"Harv. Rev. Psychiatry"},{"key":"ref_16","unstructured":"HCUP NIS Database Documentation (2018, April 20). Healthcare Cost and Utilization Project (HCUP), Available online: https:\/\/www.hcup-us.ahrq.gov\/db\/nation\/nis\/nisdbdocumentation.jsp."},{"key":"ref_17","unstructured":"NIS Description of Data Elements (2018, April 15). Healthcare Cost and Utilization Project (HCUP), Available online: https:\/\/www.hcup-us.ahrq.gov\/db\/nation\/nis\/nisdde.jsp."},{"key":"ref_18","unstructured":"HCUP CCS (2018, April 15). Healthcare Cost and Utilization Project (HCUP), Available online: https:\/\/www.hcup-us.ahrq.gov\/toolssoftware\/ccs\/ccs.jsp."},{"key":"ref_19","unstructured":"(2018, March 05). Overview of the National (Nationwide) Inpatient Sample (NIS), Available online: https:\/\/www.hcup-us.ahrq.gov\/nisoverview.jsp."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Patel, R.S., Virani, S., Saeed, H., Nimmagadda, S., Talukdar, J., and Youssef, N.A. (2018). Gender Differences and Comorbidities in U.S. Adults with Bipolar Disorder. Brain Sci., 8.","DOI":"10.3390\/brainsci8090168"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1176\/appi.psychotherapy.1984.38.3.384","article-title":"The use of electroconvulsive therapy in suicidal patients","volume":"38","author":"Frankel","year":"1984","journal-title":"Am. J. Psychother."},{"key":"ref_22","first-page":"35","article-title":"The utility of pharmacogenetic testing to support the treatment of bipolar disorder","volume":"11","author":"Ielmini","year":"2018","journal-title":"Pharmgenomics Pers. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1007\/s11920-013-0422-z","article-title":"Problematic boundaries in the diagnosis of bipolar disorder: The interface with borderline personality disorder","volume":"15","author":"Zimmerman","year":"2013","journal-title":"Curr. Psychiatry Rep."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1177\/070674370404900806","article-title":"The boundary between borderline personality disorder and bipolar disorder: Current concepts and challenges","volume":"49","author":"Magill","year":"2004","journal-title":"Can. J. Psychiatry"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1176\/ajp.2006.163.7.1173","article-title":"Descriptive and longitudinal observations on the relationship of borderline personality disorder and bipolar disorder","volume":"163","author":"Gunderson","year":"2006","journal-title":"Am. J. Psychiatry"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1521\/pedi.15.3.195.19203","article-title":"The suicidal risk in severe personality disorders: Differential diagnosis and treatment","volume":"15","author":"Kernberg","year":"2001","journal-title":"J. Pers. Disord."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"359","DOI":"10.2174\/1570159X14666161017233642","article-title":"The Role of Electroconvulsive Therapy (ECT) in Bipolar Disorder: Effectiveness in 522 Patients with Bipolar Depression, Mixed-state, Mania and Catatonic Features","volume":"15","author":"Perugi","year":"2017","journal-title":"Curr. Neuropharmacol."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.jad.2005.02.019","article-title":"Borderline personality disorder characteristics in young adults with recurrent mood disorders: A comparison of bipolar and unipolar depression","volume":"87","author":"Smith","year":"2005","journal-title":"J. Affect. Disord."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/55\/1\/13\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:25:55Z","timestamp":1760185555000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/55\/1\/13"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1,14]]},"references-count":28,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,1]]}},"alternative-id":["medicina55010013"],"URL":"https:\/\/doi.org\/10.3390\/medicina55010013","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,14]]}}}