{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:15:41Z","timestamp":1760188541459,"version":"build-2065373602"},"reference-count":21,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T00:00:00Z","timestamp":1557964800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005324","name":"Universidad Aut\u00f3noma de San Luis Potos\u00ed","doi-asserted-by":"publisher","award":["C15-FAI-04-37.37"],"award-info":[{"award-number":["C15-FAI-04-37.37"]}],"id":[{"id":"10.13039\/501100005324","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and objectives: Dipeptidyl-Peptidase 4 (DPP-4) is a protein expressed in numerous cells and tissues. Recently it has shown its involvement as a catalyst in the inflammatory response in various pulmonary, autoimmune, intestinal and other pathologies. The objective of this study was to compare the preoperative serum levels of DPP-4 in patients with and without surgical finding of perivesicular inflammation. Materials and methods: a cross-sectional analytical study nested in a prospective cohort, including patients scheduled for elective cholecystectomy, without surgical complications, that were 18\u201370 years of age, with low cardiovascular risk, without a history of peritonitis, pancreatitis, or jaundice and underwent ERCP protocol, type 2 diabetes mellitus, acute inflammatory (Protein C Reactive &lt; 3 mg\/L, leucocytes &lt; 10 1000\/mm3), neoplastic, nephrologic or liver disease, the use of anti-inflammatory drugs, steroids and\/or antibiotics, the use of pacemakers or metallic implants and without major amputations and whom agreed to participate by providing their informed consent. Ethical and Research register: 45\u201316. Prior to surgery we compiled anthropometric data and a blood sample to determine the serum levels of DPP-4. The presence of perivesicular inflammation was determined in the surgery. The data was analyzed using the statistical program Rstudio. Results: High BMI values were observed (27.8 \u00b1 6.4); waist circumference (94.7 \u00b1 15.1) and percentage of fat mass (34.7 \u00b1 11.7), showing a cumulative frequency of 65.9% for overweight\/obesity. In 27.3% of the interventions, intraoperative perivesicular inflammation findings were reported. The serum levels of DPP-4 were lower in the group of patients with perivesicular inflammation (3947.6 \u00b1 1659.5 vs. 3053.2 \u00b1 1469.6, LC95% of the difference: 160.4\u20131628.3), being statistically significant (p = 0.018). Conclusions: In the subacute or chronic phases of cholecystitis, there appears to be a constant consumption of DPP-4, which would modulate a better immune response that could be related to the reduction of postoperative complications, so the use of Serum levels of DPP-4 as an early biomarker could improve the diagnostic accuracy of this pathology and the surgical approach.<\/jats:p>","DOI":"10.3390\/medicina55050148","type":"journal-article","created":{"date-parts":[[2019,5,16]],"date-time":"2019-05-16T11:21:22Z","timestamp":1558005682000},"page":"148","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["DPP-4 as a Possible Biomarker of Inflammation Before Abdominal Surgery for Chronic Pathology: Our Experience with Elective Cholecystectomy"],"prefix":"10.3390","volume":"55","author":[{"given":"Liliana","family":"Valencia-S\u00e1nchez","sequence":"first","affiliation":[{"name":"General Surgery Department, \u201cDr. Ignacio Morones Prieto\u201d Central Hospital, San Luis Potos\u00ed 78290, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4411-4515","authenticated-orcid":false,"given":"Rafael","family":"Almendra-Pegueros","sequence":"additional","affiliation":[{"name":"Translational Research Laboratory in Pharmacology, Clinical Epidemiology Department, Faculty of Medicine, UASLP, San Luis Potos\u00ed 78210, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Jose","family":"Diaz R-Valdez","sequence":"additional","affiliation":[{"name":"General Surgery Department, \u201cDr. Ignacio Morones Prieto\u201d Central Hospital, San Luis Potos\u00ed 78290, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Esmer-S\u00e1nchez","sequence":"additional","affiliation":[{"name":"General Surgery Department, \u201cDr. Ignacio Morones Prieto\u201d Central Hospital, San Luis Potos\u00ed 78290, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4906-223X","authenticated-orcid":false,"given":"\u00darsula","family":"Medina","sequence":"additional","affiliation":[{"name":"Translational Research Laboratory in Pharmacology, Clinical Epidemiology Department, Faculty of Medicine, UASLP, San Luis Potos\u00ed 78210, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7351-4614","authenticated-orcid":false,"given":"Antonio","family":"Gordillo-Moscoso","sequence":"additional","affiliation":[{"name":"Translational Research Laboratory in Pharmacology, Clinical Epidemiology Department, Faculty of Medicine, UASLP, San Luis Potos\u00ed 78210, Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,5,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1155\/2009\/986295","article-title":"Soluble CD26 Levels and Its Association to Epidemiologic Parameters in a Sample Population","volume":"27","author":"Cordero","year":"2009","journal-title":"Dis. Markers"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.2741\/4671","article-title":"A novel role for CD26\/dipeptidyl peptidase IV as a therapeutic target","volume":"23","author":"Ohnuma","year":"2018","journal-title":"Front. Biosci."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.tips.2015.04.014","article-title":"Adipokines in health and disease","volume":"36","author":"Fasshauer","year":"2015","journal-title":"Trends Pharmacol. Sci."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"5608","DOI":"10.1046\/j.1432-1327.2000.01634.x","article-title":"Molecular characterization of dipeptidyl peptidase activity in serum: Soluble CD26\/dipeptidyl peptidase IV is responsible for the release of X-Pro dipeptides","volume":"267","author":"Durinx","year":"2000","journal-title":"Eur. J. Biochem."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s00709-017-1129-5","article-title":"Potential disease biomarkers: Dipeptidyl peptidase 4 and fibroblast activation protein","volume":"255","author":"Yazbeck","year":"2018","journal-title":"Protoplasma"},{"key":"ref_6","first-page":"386","article-title":"DPP4 in diabetes","volume":"6","year":"2015","journal-title":"Front. Immunol."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"F1584","DOI":"10.1152\/ajprenal.00477.2012","article-title":"The impact of peptidase activity on clear cell renal cell carcinoma survival","volume":"303","author":"Larrinaga","year":"2012","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"512","DOI":"10.3389\/fphar.2017.00512","article-title":"Role of Proteases in Chronic Obstructive Pulmonary Disease","volume":"8","author":"Pandey","year":"2017","journal-title":"Front. Pharmacol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.clinbiochem.2012.04.023","article-title":"Decreased soluble dipeptidyl peptidase IV activity as a potential serum biomarker for COPD","volume":"45","author":"Rumora","year":"2012","journal-title":"Clin. Biochem."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.amjms.2015.12.011","article-title":"Expression and Clinical Significance of Serum Dipeptidyl Peptidase IV Chronic Obstructive Pulmonary Disease","volume":"351","author":"Chang","year":"2016","journal-title":"Am. J. Med. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/S0002-9440(10)62266-3","article-title":"Circulating CD26 Is Negatively Associated with Inflammation in Human and Experimental Arthritis","volume":"166","author":"Busso","year":"2005","journal-title":"Am. J. Pathol."},{"key":"ref_12","doi-asserted-by":"crossref","unstructured":"Sromova, L., Busek, P., Sedova, L., and Sedo, A. (2015). Intraindividual changes of dipeptidyl peptidase-IV in peripheral blood of patients with rheumatoid arthritis are associated with the disease activity. BMC Musculoskelet. Disord., 16.","DOI":"10.1186\/s12891-015-0707-y"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1080\/003655201750422675","article-title":"Dipeptidyl Peptidase IV (DP IV, CD26) in Patients with Inflammatory Bowel Disease","volume":"36","author":"Hildebrandt","year":"2001","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.regpep.2012.04.006","article-title":"Dipeptidyl peptidase-4 expression is reduced in Crohn\u2019s disease","volume":"177","author":"Moran","year":"2012","journal-title":"Regulat. Pept."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00117-005-1224-z","article-title":"Entz\u00fcndliche Erkrankungen der Gallenblase und der Gallenwege: Teil I: Bildgebende Verfahren\u2014Cholelithiasis\u2014Entz\u00fcndungen der Gallenblase","volume":"45","author":"Helmberger","year":"2005","journal-title":"Radiologe"},{"key":"ref_16","unstructured":"Mathew, G., and Bhimji, S.S. (2018). Gallbladder, Cholecystitis, Clostridial (Gangrenous, Emphysematous). StatPearls, StatPearls Publishing."},{"key":"ref_17","unstructured":"Gordon, C., and Chumlea, W. (1988). Roche A Stature, Recumbent Length, and Weight. Anthropometric Standardization Reference Manual, Human Kinetics Books."},{"key":"ref_18","unstructured":"Callaway, C.W., Chumlea, W., and Bouchard, C. (1988). Circumferences. Anthropometric Standardization Reference Manual, Human Kinetics Books."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.suc.2014.01.005","article-title":"Cholecystitis","volume":"94","author":"Knab","year":"2014","journal-title":"Surg. Clin. N. Am."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"F661","DOI":"10.1152\/ajprenal.00316.2016","article-title":"Diabetes, hypertension, and chronic kidney disease progression: Role of DPP4","volume":"312","author":"Nistala","year":"2017","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"ref_21","first-page":"125","article-title":"Chronic cholecystitis in the pediatric population: An underappreciated disease process","volume":"10","author":"Blackwood","year":"2017","journal-title":"Gastroenterol. Hepatol. Bed Bench."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/55\/5\/148\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:52:37Z","timestamp":1760187157000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/55\/5\/148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,16]]},"references-count":21,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,5]]}},"alternative-id":["medicina55050148"],"URL":"https:\/\/doi.org\/10.3390\/medicina55050148","relation":{},"ISSN":["1648-9144"],"issn-type":[{"type":"electronic","value":"1648-9144"}],"subject":[],"published":{"date-parts":[[2019,5,16]]}}}