{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:44:39Z","timestamp":1783471479334,"version":"3.55.0"},"reference-count":38,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T00:00:00Z","timestamp":1558483200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Istanbul University Scientific Research Project Unit","award":["25214"],"award-info":[{"award-number":["25214"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and objectives: Ischemia\u2013reperfusion (IR) caused by infrarenal abdominal aorta cross-clamping is an important factor in the development of ischemia\u2013reperfusion injury in various distant organs. Materials and Methods: We investigated potential antioxidant\/anti-inflammatory effects of thymosin beta 4 (T\u03b24) in a rat model of abdominal aortic surgery-induced IR. T\u03b24 (10 mg\/kg, intravenous (i.v.)) was administered to rats with IR (90-min ischemia, 180-min reperfusion) at two different periods. One group received T\u03b24 1 h before ischemia, and the other received 15 min before the reperfusion period. Results: Results were compared to control and non-T\u03b24-treated rats with IR. Serum, bronchoalveolar lavage fluid and lung tissue levels of oxidant parameters were higher, while antioxidant levels were lower in the IR group compared to control. IR also increased inflammatory cytokine levels. T\u03b24 reverted these parameters in both T\u03b24-treated groups compared to the untreated IR group. Conclusions: Since there is no statistical difference between the prescribed results of both T\u03b24-treated groups, our study demonstrates that T\u03b24 reduced lung oxidative stress and inflammation following IR and prevented lung tissue injury regardless of timing of administration.<\/jats:p>","DOI":"10.3390\/medicina55050187","type":"journal-article","created":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T03:22:03Z","timestamp":1558581723000},"page":"187","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Protective Effect of Thymosin \u03b24 against Abdominal Aortic Ischemia\u2013Reperfusion-Induced Acute Lung Injury in Rats"],"prefix":"10.3390","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3561-3977","authenticated-orcid":false,"given":"Onur M.","family":"Yaman","sequence":"first","affiliation":[{"name":"Department of Physiology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, 34098 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1926-6947","authenticated-orcid":false,"given":"Ibrahim","family":"Guner","sequence":"additional","affiliation":[{"name":"Department of Physiology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, 34098 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulcan","family":"Guntas","sequence":"additional","affiliation":[{"name":"Department of Nursery, School of Health, University of K\u0131rklareli, 39060 K\u0131rklareli, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3796-2011","authenticated-orcid":false,"given":"Osman Fuat","family":"Sonmez","sequence":"additional","affiliation":[{"name":"Department of Physiology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, 34098 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gamze","family":"Tanriverdi","sequence":"additional","affiliation":[{"name":"Department of Histology and Embriology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, 34098 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aris","family":"Cakiris","sequence":"additional","affiliation":[{"name":"Institute of Health Sciences, Istanbul University, Genetics, 34098 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4134-3136","authenticated-orcid":false,"given":"Ugur","family":"Aksu","sequence":"additional","affiliation":[{"name":"Department of Biology, Science Faculty, Istanbul University, 34098 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibel","family":"Akyol","sequence":"additional","affiliation":[{"name":"Department of Physiology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, 34098 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif","family":"Guzel","sequence":"additional","affiliation":[{"name":"Department of Histology and Embriology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, 34098 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1347-8498","authenticated-orcid":false,"given":"Hafize","family":"Uzun","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, 34098 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nermin","family":"Yelmen","sequence":"additional","affiliation":[{"name":"Department of Physiology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, 34098 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulderen","family":"Sahin","sequence":"additional","affiliation":[{"name":"Department of Physiology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, 34098 Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,5,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.3349\/ymj.2011.52.2.339","article-title":"Risk Factors for Postoperative Complications after Open Infrarenal Abdominal Aortic Aneurysm Repair in Koreans","volume":"52","author":"Kim","year":"2011","journal-title":"Yonsei Med. 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