{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:39:10Z","timestamp":1760240350579,"version":"build-2065373602"},"reference-count":16,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T00:00:00Z","timestamp":1558915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Interstitial ectopic pregnancy (EP) is a life-threatening condition due to the risk of massive hemorrhage in the event of its disturbance. We present the case of a 27-year-old patient who was admitted with massive hemoperitoneum, caused by the rupture of an interstitial pregnancy in the area of the fallopian tube stump, which had been removed after a previous ectopic pregnancy. The condition was overcome using a mini-laparoscopic approach (2.6 mm, 30\u00b0 optics), with one 3 mm port for micro-laparoscopic instruments and one 10 mm port. Such an approach has not yet been reported in the available literature, among the casuistically reported cases of pregnancy in the tubal stump. We consider that the technique is safe, completely in the interest of the patient, applicable by an experienced team, and in agreement with modern trends regarding the minimization of operative access.<\/jats:p>","DOI":"10.3390\/medicina55050215","type":"journal-article","created":{"date-parts":[[2019,5,27]],"date-time":"2019-05-27T11:19:27Z","timestamp":1558955967000},"page":"215","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Disturbed Interstitial Pregnancy: A First Case of Successful Treatment Using a Mini-Laparoscopic Approach"],"prefix":"10.3390","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8673-2082","authenticated-orcid":false,"given":"Latchesar","family":"Tantchev","sequence":"first","affiliation":[{"name":"Obstetrics and Gynecology Clinic, Acibadem City Clinic Hospital \u201cTokuda\u201d, PC 1000 Sofia City, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2178-8517","authenticated-orcid":false,"given":"Andrey","family":"Kotzev","sequence":"additional","affiliation":[{"name":"Clinic of Gastroenterology, University Hospital for Active Treatment \u201cAlexandrovska\u201d, PC 1000 Sofia City, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7719-382X","authenticated-orcid":false,"given":"Angel","family":"Yordanov","sequence":"additional","affiliation":[{"name":"Clinic of Oncological Gynecology, University General Hospital for Active Treatment \u201cDr. G. Stranski\u201d, PC 5800 Pleven City, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,5,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/j.1447-0756.2006.00385.x","article-title":"Spontaneous ectopic pregnancy occurring in the isthmic portion of the remnant tube after ipsilateral adnexectomy: Report of two cases","volume":"32","author":"Takeda","year":"2006","journal-title":"J. Obs. Gynaecol. Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1093\/oxfordjournals.aje.a009747","article-title":"Estimates of the annual number of clinically recognized pregnancies in the United States, 1981\u20131991","volume":"149","author":"Saraiya","year":"1999","journal-title":"Am. J. Epidemiol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1111\/jog.12332","article-title":"Pregnancy outcomes after emergent laparoscopic surgery for acute adnexal disorders at less than 10 weeks of gestation","volume":"40","author":"Takeda","year":"2014","journal-title":"J. Obs. Gynaecol. Res."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Ko, P.C., Liang, C.C., Lo, T.S., and Huang, H.Y. (2011). Six cases of tubal stump pregnancy: Complication of assisted reproductive technology?. Fertil. Steril., 95.","DOI":"10.1016\/j.fertnstert.2011.03.069"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.mefs.2013.01.004","article-title":"Challenges in the diagnosis and management of interstitial and cornual ectopic pregnancies","volume":"18","author":"Botros","year":"2013","journal-title":"Middle East Fertil. Soc. J."},{"key":"ref_6","unstructured":"Piccioni, M.G., Riganelli, L., Donfrancesco, C., Savone, D., Caccetta, J., Merlino, L., Mariani, M., Vena, F., and Aragona, C. (2017). Ectopic pregnancy of the tubal stump in ART patients, two case reports and a review of the literature. Medical Case Reports, MedPub LTD."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.jmig.2011.03.019","article-title":"Minilaparoscopic versus conventional laparoscopic hysterectomy: Results of a randomized trial","volume":"18","author":"Ghezzi","year":"2011","journal-title":"J. Minim. Invasive Gynecol."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0020-7292(97)00274-9","article-title":"Single dose methotrexate therapy: Application to interstitial ectopic pregnancy","volume":"60","author":"Borgatta","year":"1998","journal-title":"Int. J. Gynaecol. Obs."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/S0015-0282(16)46349-1","article-title":"Treatment of interstitial ectopic pregnancy with methotrexate: Report of a successful case","volume":"37","author":"Tanaka","year":"1982","journal-title":"Fertil. Steril."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/S0889-8545(21)00336-3","article-title":"Mini-laparoscopy and fiber-optic lasers. Obstet","volume":"18","author":"Dorsey","year":"1991","journal-title":"Gynecol. Clin. North Am."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S1074-3804(99)80049-8","article-title":"Minilaparoscopic hysterectomy","volume":"6","author":"Wattiez","year":"1999","journal-title":"J. Am. Assoc. Gynecol. Laparosc."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.ygyno.2009.01.015","article-title":"Microlaparoscopy: A further development of minimally invasive surgery for endometrial cancer staging\u2014Initial experience","volume":"113","author":"Ghezzi","year":"2009","journal-title":"Gynecol. Oncol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"111","DOI":"10.4293\/108680812X13517013318319","article-title":"Total microlaparoscopy radical hysterectomy in early cervical cancer patients: Surgical technique and preliminary results","volume":"17","author":"Fanfani","year":"2013","journal-title":"JSLS"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.ejso.2013.07.096","article-title":"Minilaparoscopic radical hysterectomy for cervical cancer: Multi-institutional","volume":"39","author":"Ghezzi","year":"2013","journal-title":"Eur. J. Surg. Oncol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1089\/lap.2015.0381","article-title":"Minilaparoscopic versus conventional laparoscopic sacrocolpopexy: A comparative study","volume":"26","author":"Ferreira","year":"2016","journal-title":"J. Laparoendosc. Adv. Surg. Tech. A"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1089\/lap.2014.0478","article-title":"Minilaparoscopic versus standard laparoscopic hysterectomy for uteri \u2265 16 weeks of gestation: Surgical outcomes, postoperative quality of life, and cosmesis","volume":"25","author":"Uccella","year":"2015","journal-title":"J. Laparoendosc. Adv. Surg. Tech. A"}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/55\/5\/215\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T12:53:54Z","timestamp":1760187234000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/55\/5\/215"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,27]]},"references-count":16,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2019,5]]}},"alternative-id":["medicina55050215"],"URL":"https:\/\/doi.org\/10.3390\/medicina55050215","relation":{},"ISSN":["1648-9144"],"issn-type":[{"type":"electronic","value":"1648-9144"}],"subject":[],"published":{"date-parts":[[2019,5,27]]}}}