{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T03:40:02Z","timestamp":1760240402114,"version":"build-2065373602"},"reference-count":24,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T00:00:00Z","timestamp":1559692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Studies suggest that FAS\/FASL polymorphisms are associated with male infertility; however, their results are still inconclusive. Therefore, this systematic review and meta-analysis aimed to summarize and clarify the overall association of FAS\/FASL polymorphisms and risk of male infertility. Materials and Methods: Our search was conducted on the databases of Science Direct, PubMed and Google Scholar. For performing the meta-analysis, pooled odds ratio (OR) values with 95% confidence interval (CI) was applied in order to analyze the strength of association between the FAS\/FASL polymorphisms and risk of male infertility. A total of seven relevant studies published up to September 2018 were considered. Results: FASL-844C\/T genotype results of 559 patients and 623 healthy individuals were included in our study. For FAS-670A\/G genotype effect, 751 patients and 821 healthy individuals were explored. Results showed that all analysis models including dominant, recessive and allelic models of FASL-844C\/T and FAS-670A\/G polymorphism had no significant effect on infertility in men (p &gt; 0.05 and p &gt; 0.05, respectively). According to sensitivity analysis, our results were stable. Conclusion: We demonstrated that FAS\/FASL polymorphisms might not be an effective factor on male reproductive health. For precise determination of FAS\/FASL polymorphisms effects on male infertility, large-scale case-control studies should be performed.<\/jats:p>","DOI":"10.3390\/medicina55060247","type":"journal-article","created":{"date-parts":[[2019,6,6]],"date-time":"2019-06-06T03:38:01Z","timestamp":1559792281000},"page":"247","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association between the FAS\/FASL Variants and Risk of Male Infertility in Asian Populations; A Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"55","author":[{"given":"Rezvan","family":"Asgari","sequence":"first","affiliation":[{"name":"Medical Biology Research Center (MBRC), Kermanshah University of Medical Sciences, Kermanshah 6714415185, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamran","family":"Mansouri","sequence":"additional","affiliation":[{"name":"Medical Biology Research Center (MBRC), Kermanshah University of Medical Sciences, Kermanshah 6714415185, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitra","family":"Bakhtiari","sequence":"additional","affiliation":[{"name":"Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah 6714869914, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadi","family":"Mozafari","sequence":"additional","affiliation":[{"name":"Medical Biology Research Center (MBRC), Kermanshah University of Medical Sciences, Kermanshah 6714415185, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiva","family":"Roshankhah","sequence":"additional","affiliation":[{"name":"Fertility and Infertility Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah 6714869914, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,6,5]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.fertnstert.2012.11.037","article-title":"Prevalence of infertility in the United States as estimated by the current duration approach and a traditional constructed approach","volume":"99","author":"Thoma","year":"2013","journal-title":"Fertil. 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