{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:30:48Z","timestamp":1762867848918,"version":"build-2065373602"},"reference-count":20,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T00:00:00Z","timestamp":1562112000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>A 56-year-old man with severe asthma underwent bronchial thermoplasty (BT). However, his asthma exacerbated and hypereosinophilia developed 2 months later, thus necessitating oral corticosteroid (OCS) therapy. Six months after BT, a diagnosis of severe asthma with eosinophilic chronic rhinosinusitis (ECRS) was made and benralizumab treatment was initiated; the blood eosinophil count subsequently decreased and lung function improved, thereby permitting OCS dose tapering. Surprisingly, benralizumab both reduced nasal polyps and ameliorated ECRS. Thus, benralizumab may be a useful drug for the rapid treatment of severe asthma with ECRS, especially in patients with hypereosinophilia.<\/jats:p>","DOI":"10.3390\/medicina55070336","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T11:14:49Z","timestamp":1562152489000},"page":"336","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Rapid Effect of Benralizumab for Hypereosinophilia in a Case of Severe Asthma with Eosinophilic Chronic Rhinosinusitis"],"prefix":"10.3390","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0837-9329","authenticated-orcid":false,"given":"Hiroaki","family":"Tsurumaki","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine, Gunma University Graduate School of Medicine, Maebashi 371-8511, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Matsuyama","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Gunma University Graduate School of Medicine, Maebashi 371-8511, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuma","family":"Ezawa","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Gunma University Graduate School of Medicine, Maebashi 371-8511, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4974-9026","authenticated-orcid":false,"given":"Yasuhiko","family":"Koga","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Gunma University Graduate School of Medicine, Maebashi 371-8511, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakiyo","family":"Yatomi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Gunma University Graduate School of Medicine, Maebashi 371-8511, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruka","family":"Aoki-Saito","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Gunma University Graduate School of Medicine, Maebashi 371-8511, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuaki","family":"Chikamatsu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Gunma University Graduate School of Medicine, Maebashi 371-8511, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Hisada","sequence":"additional","affiliation":[{"name":"Gunma University Graduate School of Health Sciences, Maebashi 371-8514, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,7,3]]},"reference":[{"key":"ref_1","unstructured":"Global Initiative for Asthma (2019, April 06). 2018 GINA Report, Global Strategy for Asthma Management and Prevention. 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