{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:25:05Z","timestamp":1793413505550,"version":"4.5.0"},"reference-count":17,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2019,7,8]],"date-time":"2019-07-08T00:00:00Z","timestamp":1562544000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Trisomy 18 is a genetic disease resulting from an extra chromosome 18, characterized by a broad clinical spectrum, poor prognosis and low rates of survival. This is the case of a 12 year-old girl diagnosed with full trisomy 18, and multiple malformations, including Dandy-Walker Syndrome and congenital heart defects on long term survival. At nine months, a new echocardiogram showed a double outlet right ventricle, significant pulmonary stenosis, patent ductus arteriosus and ventricular septal defect. Cardiac surgery was performed at one year and seven months. Early surgical intervention and multidisciplinary follow-up may change the clinical outcome of the disease. Further studies are required to evaluate the benefit of invasive procedures such as cardiac surgery on survival of patients with trisomy 18.<\/jats:p>","DOI":"10.3390\/medicina55070352","type":"journal-article","created":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T03:05:26Z","timestamp":1562727926000},"page":"352","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Long Survival of a Patient with Trisomy 18 and Dandy-Walker Syndrome"],"prefix":"10.3390","volume":"55","author":[{"given":"Leonardo","family":"Moura Ferreira de Souza","sequence":"first","affiliation":[{"name":"Department of Pediatric of Federal, University of Rio Grande do Norte, Natal 58051-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9443-7067","authenticated-orcid":false,"given":"Augusto","family":"Galv\u00e3o e Brito Medeiros","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande do Norte, Natal 58051-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7394-7586","authenticated-orcid":false,"given":"Jos\u00e9 Paulo","family":"Ribeiro J\u00fanior","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande do Norte, Natal 58051-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurea","family":"Nogueira de Melo","sequence":"additional","affiliation":[{"name":"Department of Pediatric of Federal, University of Rio Grande do Norte, Natal 58051-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8533-5023","authenticated-orcid":false,"given":"Sylvyo Andr\u00e9 Morais Medeiros","family":"Dias","sequence":"additional","affiliation":[{"name":"Federal University of Rio Grande do Norte, Natal 58051-900, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,7,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1590\/S0103-05822013000100018","article-title":"Trissomia 18: Revis\u00e3o dos aspectos cl\u00ednicos, etiol\u00f3gicos, progn\u00f3sticos e \u00e9ticos","volume":"31","author":"Rosa","year":"2013","journal-title":"Rev. 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