{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:34:16Z","timestamp":1790814856062,"version":"4.1.0"},"reference-count":69,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T00:00:00Z","timestamp":1563148800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Celiac disease (CD) is a systemic autoimmune disease driven by gluten-ingestion in genetically predisposed individuals. Although it primarily affects the small bowel, CD can also involve other organs and manifest as an extraintestinal disease. Among the extraintestinal features of CD, hematologic ones are rather frequent and consist of anemia, thrombocytosis (thrombocytopenia also, but rare), thrombotic or hemorrhagic events, IgA deficiency, hyposplenism, and lymphoma. These hematologic alterations can be the sole manifestation of the disease and should prompt for CD testing in a suggestive clinical scenario. Recognition of these atypical, extraintestinal presentations, including hematologic ones, could represent a great opportunity to increase the diagnostic rate of CD, which is currently one of the most underdiagnosed chronic digestive disorders worldwide. In this review, we summarize recent evidence regarding the hematological manifestations of CD, with focus on practical recommendations for clinicians.<\/jats:p>","DOI":"10.3390\/medicina55070373","type":"journal-article","created":{"date-parts":[[2019,7,16]],"date-time":"2019-07-16T02:23:16Z","timestamp":1563243796000},"page":"373","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Hematologic Manifestations in Celiac Disease\u2014A Practical Review"],"prefix":"10.3390","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3436-8041","authenticated-orcid":false,"given":"Daniel Vasile","family":"Balaban","sequence":"first","affiliation":[{"name":"\u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Gastroenterology Department, \u201cDr. Carol Davila\u201d Central Military Emergency University Hospital, 010825 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Popp","sequence":"additional","affiliation":[{"name":"\u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Pediatrics Department, \u201cAlessandrescu-Rusescu\u201d National Institute for Mother and Child Health, 020395 Bucharest, Romania"},{"name":"Faculty of Medicine and Health Technology, Tampere University and Tampere University Hospital, 33100 Tampere, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florentina","family":"Ionita Radu","sequence":"additional","affiliation":[{"name":"Gastroenterology Department, \u201cDr. Carol Davila\u201d Central Military Emergency University Hospital, 010825 Bucharest, Romania"},{"name":"Faculty of Medicine, Titu Maiorescu University, 004051 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana","family":"Jinga","sequence":"additional","affiliation":[{"name":"\u201cCarol Davila\u201d University of Medicine and Pharmacy, 020021 Bucharest, Romania"},{"name":"Gastroenterology Department, \u201cDr. Carol Davila\u201d Central Military Emergency University Hospital, 010825 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,7,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"6036","DOI":"10.3748\/wjg.v18.i42.6036","article-title":"Celiac disease: Prevalence, diagnosis, pathogenesis and treatment","volume":"18","author":"Gujral","year":"2012","journal-title":"World J. Gastroenterol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.cgh.2017.06.037","article-title":"Global prevalence of celiac disease: Systematic review and meta-analysis","volume":"16","author":"Singh","year":"2018","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nrgastro.2015.131","article-title":"Extraintestinal manifestations of coeliac disease","volume":"12","author":"Leffler","year":"2015","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Reunala, T., Salmi, T.T., Hervonen, K., Kaukinen, K., and Collin, P. (2018). Dermatitis Herpetiformis: A Common Extraintestinal Manifestation of Coeliac Disease. Nutrients, 10.","DOI":"10.3390\/nu10050602"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1159\/000369541","article-title":"Extraintestinal manifestations of celiac disease","volume":"33","author":"Bercik","year":"2015","journal-title":"Dig. Dis."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Rodrigo, L., Beteta-Gorriti, V., Alvarez, N., G\u00f3mez de Castro, C., de Dios, A., Palacios, L., and Santos-Juanes, J. (2018). Cutaneous and mucosal manifestations associated with celiac disease. Nutrients, 10.","DOI":"10.20944\/preprints201805.0158.v1"},{"key":"ref_7","first-page":"3","article-title":"Rheumatologic manifestations in celiac disease","volume":"57","author":"Dima","year":"2019","journal-title":"Rom. J. Intern. Med."},{"key":"ref_8","first-page":"197","article-title":"Neurological disorders and celiac disease","volume":"62","author":"Casella","year":"2016","journal-title":"Minerva Gastroenterol. Dietol."},{"key":"ref_9","first-page":"89","article-title":"Liver steatosis in celiac disease: The open door","volume":"59","author":"Abenavoli","year":"2013","journal-title":"Minerva Gastroenterol. Dietol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"663","DOI":"10.3906\/sag-1402-169","article-title":"The hematologic manifestations of pediatric celiac disease at the time of diagnosis and efficiency of gluten free diet","volume":"45","author":"Catal","year":"2015","journal-title":"Turk. J. Med. Sci."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"419","DOI":"10.5152\/tjg.2018.17236","article-title":"Physicians\u2019 attitude and perception regarding celiac disease: A questionnaire-based study","volume":"29","author":"Jinga","year":"2018","journal-title":"Turk. J. Gastroenterol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.3109\/00365521.2012.706828","article-title":"Hematological manifestations of celiac disease","volume":"47","author":"Baydoun","year":"2012","journal-title":"Scand. J. Gastroenterol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1182\/blood-2006-07-031104","article-title":"Hematologic manifestations of celiac disease","volume":"109","author":"Halfdanarson","year":"2007","journal-title":"Blood"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"335","DOI":"10.5694\/j.1326-5377.1979.tb104135.x","article-title":"Coeliac disease. Haematological features, and delay in diagnosis","volume":"2","author":"Croese","year":"1979","journal-title":"Med. J. Aust."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1111\/j.1572-0241.2007.01167.x","article-title":"Where are all those patients with Celiac disease?","volume":"102","author":"Green","year":"2007","journal-title":"Am. J. Gastroenterol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/ajg.2013.79","article-title":"American College of Gastroenterology. ACG clinical guidelines: Diagnosis and management of celiac disease","volume":"108","author":"Hill","year":"2013","journal-title":"Am. J. Gastroenterol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1136\/gutjnl-2013-306578","article-title":"BSG Coeliac Disease Guidelines Development Group; British Society of Gastroenterology. Diagnosis and management of adult coeliac disease: Guidelines from the British Society of Gastroenterology","volume":"63","author":"Ludvigsson","year":"2014","journal-title":"Gut"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1097\/MPG.0b013e31821a23d0","article-title":"ESPGHAN Working Group on Coeliac Disease Diagnosis; ESPGHAN Gastroenterology Committee; European Society for Pediatric Gastroenterology, Hepatology, and Nutrition guidelines for the diagnosis of coeliac disease","volume":"54","author":"Husby","year":"2012","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1177\/2050640619844125","article-title":"European Society for the Study of Coeliac Disease (ESsCD) guideline for coeliac disease and other gluten-related disorders","volume":"7","author":"Volta","year":"2019","journal-title":"UEG J."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/jgh3.12073","article-title":"Anemia in celiac disease is multifactorial in etiology: A prospective study from India","volume":"2","author":"Berry","year":"2018","journal-title":"JGH Open"},{"key":"ref_21","first-page":"45","article-title":"Diagnostic accuracy of red blood cell distribution width-to-lymphocyte ratio for celiac disease","volume":"26","author":"Balaban","year":"2018","journal-title":"Rev. Romana Med. Lab."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1053\/j.gastro.2016.01.029","article-title":"Clinical and immunologic features of ultra-short celiac disease","volume":"150","author":"Mooney","year":"2016","journal-title":"Gastroenterology"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s10620-018-5323-x","article-title":"Ultra-short celiac disease is a distinct and milder phenotype of the disease in children","volume":"64","author":"Doyev","year":"2019","journal-title":"Dig. Dis. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1097\/MPG.0000000000001234","article-title":"Anemia and Iron Deficiency in Children with Potential Celiac Disease","volume":"64","author":"Repo","year":"2017","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_25","doi-asserted-by":"crossref","unstructured":"Popp, A., and Maki, M. (2019). Gluten-induced extra-intestinal manifestations in potential celiac disease-celiac trait. Nutrients, 11.","DOI":"10.3390\/nu11020320"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1053\/j.gastro.2018.04.016","article-title":"Prevalence of celiac disease in patients with iron deficiency anemia\u2014A systematic review and meta-analysis","volume":"155","author":"Mahadev","year":"2018","journal-title":"Gastroenterology"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"3975","DOI":"10.3390\/nu5103975","article-title":"Vitamin and mineral deficiencies are highly prevalent in newly diagnosed celiac disease patients","volume":"5","author":"Wierdsma","year":"2013","journal-title":"Nutrients"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1097\/MPG.0000000000001475","article-title":"Serum vitamins and minerals at diagnosis and follow-up in children with celiac disease","volume":"65","author":"Deora","year":"2017","journal-title":"J. Ped. Gastroenterol. Nutr."},{"key":"ref_29","doi-asserted-by":"crossref","unstructured":"Laurikka, P., Nurminen, S., Kivel\u00e4, L., and Kurppa, K. (2018). Extraintestinal manifestations of celiac disease: Early detection for better long-term outcomes. Nutrients, 10.","DOI":"10.3390\/nu10081015"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s10151-018-1756-7","article-title":"Random duodenal biopsy to exclude coeliac disease as a cause of anaemia is not cost-effective and should be replaced with universally performed pre-endoscopy serology in patients on a suspected cancer pathway","volume":"22","author":"Herrod","year":"2018","journal-title":"Tech. Coloproctol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1097\/01.mcg.0000139034.38568.51","article-title":"The usefulness of routine small bowel biopsies in evaluation of iron deficiency anemia","volume":"38","author":"Grisolano","year":"2004","journal-title":"J. Clin. Gastroenterol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1136\/pgmj.2003.014670","article-title":"Value of routine duodenal biopsy in diagnosing coeliac disease in patients with iron deficiency anaemia","volume":"80","author":"Mandal","year":"2004","journal-title":"Postgrad. Med. J."},{"key":"ref_33","doi-asserted-by":"crossref","unstructured":"Lau, M.S., Mooney, P., White, W., Appleby, V., Moreea, S., Haythem, I., Elias, J.E., Bundhoo, K., Corbett, G.D., and Wong, L. (2016). Pre-endoscopy point of care test (Simtomax- IgA\/IgG-Deamidated Gliadin Peptide) for coeliac disease in iron deficiency anaemia: Diagnostic accuracy and a cost saving economic model. BMC Gastroenterol., 16.","DOI":"10.1186\/s12876-016-0536-y"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1136\/gut.2010.228874","article-title":"British Society of Gastroenterology. Guidelines for the management of iron deficiency anaemia","volume":"60","author":"Goddard","year":"2011","journal-title":"Gut"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.3324\/haematol.2008.000828","article-title":"Ironing out the mechanism of anemia in celiac disease","volume":"93","author":"Hershko","year":"2008","journal-title":"Hematologica"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/MPG.0000000000001420","article-title":"Extraintestinal Manifestations of Celiac Disease: Effectiveness of the Gluten-Free Diet","volume":"65","author":"Jericho","year":"2017","journal-title":"J. Pediatr. Gastroenterol. Nutr."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1097\/00042737-200506000-00005","article-title":"Are lower gastrointestinal investigations necessary in patients with coeliac disease?","volume":"17","author":"Hopper","year":"2005","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1177\/1756283X11398736","article-title":"Diagnosis and management of iron deficiency anemia in the 21st century","volume":"4","author":"Graham","year":"2011","journal-title":"Adv. Gastroenterol."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1002\/ajh.20996","article-title":"Anemia in celiac disease is multifactorial in etiology","volume":"82","author":"Harper","year":"2007","journal-title":"Am. J. Hematol."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.3324\/haematol.13255","article-title":"Anemia of chronic disease and defective erythropoetin production in patients with celiac disease","volume":"93","author":"Bergamaschi","year":"2008","journal-title":"Hematologica"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"470","DOI":"10.2350\/14-05-1489-CR.1","article-title":"A rare association of celiac disease and aplastic anemia: Case report of a child a review of the literature","volume":"17","author":"Badyal","year":"2014","journal-title":"Pediatr. Dev. Pathol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1007\/s12288-014-0331-2","article-title":"Rare association of coeliac disease with aplastic anemia. report of a case from India","volume":"30","author":"Basu","year":"2014","journal-title":"Indian J. Hematol. Blood Transfus."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s12288-014-0425-x","article-title":"Celiac disease with pure red cell aplasia: An unusual hematologic association in pediatric age group","volume":"30","author":"Chatterjee","year":"2014","journal-title":"Indian J. Hematol. Blood Transfus."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"311","DOI":"10.12998\/wjcc.v7.i3.311","article-title":"Celiac crisis, a rare occurrence in adult celiac disease: A systematic review","volume":"7","author":"Balaban","year":"2019","journal-title":"World J. Clin. Cases"},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"93","DOI":"10.15403\/jgld.2014.1121.271.cld","article-title":"Hemorrhagic Events in Adult Celiac Disease Patients. Case Report and Review of the Literature","volume":"27","author":"Dima","year":"2018","journal-title":"J. Gastrointestin. Liver Dis."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1080\/73-0891693021000005402","article-title":"Factor XIII and tissue transglutaminase antibodies in coeliac and inflammatory bowel disease","volume":"35","author":"Eriksson","year":"2002","journal-title":"Autoimmunity"},{"key":"ref_47","first-page":"5236918","article-title":"Deep Venous Thrombosis and Bilateral Pulmonary Embolism Revealing Silent Celiac Disease: Case Report and Review of the Literature","volume":"2017","author":"Dumic","year":"2017","journal-title":"Case Rep. Gastrointest. Med."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"652","DOI":"10.4330\/wjc.v9.i8.652","article-title":"Cardiovascular involvement in celiac disease","volume":"9","author":"Ciaccio","year":"2017","journal-title":"World J. Cardiol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s13760-016-0698-y","article-title":"Recurrent cerebral venous thrombosis revealing celiac disease: An exceptional case report","volume":"117","author":"Beyrouti","year":"2017","journal-title":"Acta Neurol. Belg."},{"key":"ref_50","first-page":"1","article-title":"Celiac disease with Budd-Chiari syndrome: A rare association","volume":"7","author":"Meena","year":"2019","journal-title":"SAGE Open Med. Case Rep."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1365-2141.2007.06766.x","article-title":"Risk of thromboembolism in 14,000 individuals with coeliac disease","volume":"139","author":"Ludvigsson","year":"2007","journal-title":"Br. J. Haematol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/j.autrev.2014.07.004","article-title":"Hypercoagulability in celiac disease\u2014An update","volume":"13","author":"Lerner","year":"2014","journal-title":"Autoimmun. Rev."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.dld.2017.11.018","article-title":"Elevated serum antiphospholipid antibodies in adults with celiac disease","volume":"50","author":"Laine","year":"2018","journal-title":"Dig. Liver Dis."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"e1612","DOI":"10.1097\/MD.0000000000001612","article-title":"Association between coeliac disease and risk of any malignancy and gastrointestinal malignancy: A meta-analysis","volume":"94","author":"Han","year":"2015","journal-title":"Medicine (Baltimore)"},{"key":"ref_55","first-page":"A50","article-title":"Risk of lymphomas and gastrointestinal carcinomas after a diagnosis of celiac disease based on a nationwide population-based case-control. study","volume":"5","author":"Nijeboer","year":"2017","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"169","DOI":"10.7326\/0003-4819-159-3-201308060-00006","article-title":"Mucosal healing and risk for lymphoproliferative malignancy in celiac disease: A population-based cohort study","volume":"159","author":"Lebwohl","year":"2013","journal-title":"Ann. Intern. Med."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1136\/gut.2003.024836","article-title":"In vivo targeting of intestinal and extraintestinal transglutaminase 2 by coeliac autoantibodies","volume":"53","author":"Halttunen","year":"2004","journal-title":"Gut"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1177\/2050640616663571","article-title":"Splenic volume differentiates complicated and non-complicated celiac disease","volume":"5","author":"Nijeboer","year":"2017","journal-title":"UEG J."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.3748\/wjg.v19.i15.2313","article-title":"Is it worth investigating splenic function in patients with celiac disease","volume":"19","author":"Brunetti","year":"2013","journal-title":"World J. Gastroenterol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"e726","DOI":"10.1097\/MD.0000000000000726","article-title":"Ratio of spleen diameter to red blood cell distribution width: A novel indicator for celiac disease. Medicine (Baltimore)","volume":"94","author":"Balaban","year":"2015","journal-title":"Medicine"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Canova, C., Ludvigsson, J., Baldo, V., Amidei, C.B., Zanier, A., and Zingone, F. (2019). Risk of bacterial pneumonia and pneymococcal infection in youths with celiac disease-A population-based study. Dig. Liver Dis.","DOI":"10.1016\/j.dld.2019.02.010"},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.amjmed.2017.07.021","article-title":"Celiac disease and increased risk of pneumococcal infection: A systematic review and meta-analysis","volume":"131","author":"Simons","year":"2018","journal-title":"Am. J. Med."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1177\/1403494817714713","article-title":"Increased risk of herpes zoster in patients with coeliac disease-nationwide cohort study","volume":"46","author":"Ludvigsson","year":"2018","journal-title":"Scand. J. Public Health"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1038\/ajg.2017.400","article-title":"Risk of Clostridium difficile Infection in Patients with Celiac Disease: A Population-Based Study","volume":"112","author":"Lebwohl","year":"2017","journal-title":"Am. J. Gastroenterol."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1136\/gut.2008.151571","article-title":"Coeliac disease and the risk of infections","volume":"57","author":"Walters","year":"2008","journal-title":"Gut"},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1111\/j.1365-2036.2010.04572.x","article-title":"Risk of tuberculosis in a large sample of patients with celiac disease-a nationwide cohort study","volume":"33","author":"Ludvigsson","year":"2011","journal-title":"Aliment. Pharm."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1177\/2050640617707868","article-title":"Mucosal healing and the risk of serious infections in patients with celiac disease","volume":"6","author":"Emilsson","year":"2018","journal-title":"United Eur. Gastroenterol. J."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Wang, N., Truedsson, L., Elvin, K., Andersson, B.A., R\u00f6nnelid, J., Mincheva-Nilsson, L., Lindkvist, A., Ludvigsson, J.F., Hammarstr\u00f6m, L., and Dahle, C. (2014). Serological assessment for celiac disease in IgA deficient adults. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0093180"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"226","DOI":"10.21307\/immunohematology-2019-454","article-title":"Review: IgA anaphylactic transfusion reactions, part I: Laboratory diagnosis, incidence, and supply of IgA-deficient products","volume":"20","author":"Vassallo","year":"2004","journal-title":"Immunohematology"}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/55\/7\/373\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:05:42Z","timestamp":1760187942000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/55\/7\/373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,15]]},"references-count":69,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2019,7]]}},"alternative-id":["medicina55070373"],"URL":"https:\/\/doi.org\/10.3390\/medicina55070373","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,15]]}}}