{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:35:47Z","timestamp":1772584547267,"version":"3.50.1"},"reference-count":16,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2019,8,25]],"date-time":"2019-08-25T00:00:00Z","timestamp":1566691200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Mastocytosis is a rare disease in which heightened amounts of mast cells accumulate in the skin, bone marrow, and other visceral organs. Upon activation, mast cells release a wide variety of preformed or newly synthesized mediators which can induce allergic symptoms and inflammatory reactions. Mastocytosis is diagnosed by biopsy and can be divided into cutaneous and systemic mastocytosis (SM). The first one affects the skin and is relatively benign, whilst SM, which involves bone marrow and other organs, may be aggressive and associate with both myelodisplastic and myeloproliferative diseases. Here we present a case of SM associated with essential thrombocythemia and complicated by severe osteoporosis, successfully treated with hydroxyurea, low-dose aspirin and zolendronic acid.<\/jats:p>","DOI":"10.3390\/medicina55090528","type":"journal-article","created":{"date-parts":[[2019,8,26]],"date-time":"2019-08-26T04:38:23Z","timestamp":1566794303000},"page":"528","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Systemic Mastocytosis and Essential Thrombocythemia: Case Report and Literature Overview"],"prefix":"10.3390","volume":"55","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2246-9144","authenticated-orcid":false,"given":"Mauro","family":"Cancian","sequence":"first","affiliation":[{"name":"First Medical Clinic, Department of Medicine, University of Padova, I-35128 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Cosi","sequence":"additional","affiliation":[{"name":"First Medical Clinic, Department of Medicine, University of Padova, I-35128 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Pizzi","sequence":"additional","affiliation":[{"name":"Surgical Pathology and Cytopathology Unit, Department of Medicine, University of Padova, I-35128 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandro","family":"Giannini","sequence":"additional","affiliation":[{"name":"First Medical Clinic, Department of Medicine, University of Padova, I-35128 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Bertozzi","sequence":"additional","affiliation":[{"name":"First Medical Clinic, Department of Medicine, University of Padova, I-35128 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Fabris","sequence":"additional","affiliation":[{"name":"First Medical Clinic, Department of Medicine, University of Padova, I-35128 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7945-1864","authenticated-orcid":false,"given":"Maria Luigia","family":"Randi","sequence":"additional","affiliation":[{"name":"First Medical Clinic, Department of Medicine, University of Padova, I-35128 Padova, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,8,25]]},"reference":[{"key":"ref_1","unstructured":"Swerdlow, S.H., Campo, E., Harris, N.L., Jaffe, E.S., Pileri, S.A., Stein, H., and Thiele, J. (2008). Mastocytosis. WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, World Health Organization. [4th ed.]."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1016\/j.jaci.2012.10.015","article-title":"Prevalence of indolent systemic mastocytosis in a Dutch region","volume":"131","author":"Arends","year":"2013","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.leukres.2019.04.001","article-title":"Relevant updates in systemic mastocytosis","volume":"81","author":"Coltoff","year":"2019","journal-title":"Leuk. 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Disord."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1127.e1","DOI":"10.1016\/j.amjmed.2014.06.015","article-title":"Zoledronic Acid in Osteoporosis Secondary to Mastocytosis","volume":"127","author":"Rossini","year":"2014","journal-title":"Am. J. 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