{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:25:55Z","timestamp":1792009555084,"version":"4.4.0"},"reference-count":45,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T00:00:00Z","timestamp":1566864000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Sectorial Operational Programme Human Resources Development (SOPHRD), financed by the European Social Fund and the Romanian Government","award":["POSDRU 141531\/2014."],"award-info":[{"award-number":["POSDRU 141531\/2014."]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: Anabolic androgenic steroids (AAS), used as a therapy in various diseases and abused in sports, are atherogenic in supraphysiological administration, altering the plasma lipid profile. Taurine, a conditionally-essential amino acid often used in dietary supplements, was acknowledged to delay the onset and progression of atherogenesis, and to mitigate hyperlipidemia. The aim of the present study was to verify if taurine could prevent the alterations induced by concomitant chronic administration of high doses of AAS nandrolone decanoate (DECA) in rats. Materials and Methods: Thirty-two male Wistar rats, assigned to 4 equal groups, were treated for 12 weeks either with DECA (A group), taurine (T group), both DECA and taurine (AT group) or vehicle (C group). Plasma triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), hepatic triglycerides (TGh) and liver non-esterified fatty acids (NEFA) were then determined. Results: DECA elevated TG level in A group vs. control (p = 0.01), an increase prevented by taurine association in AT group (p = 0.04). DECA decreased HDL-C in A group vs. control (p = 0.02), while taurine tended to increase it in AT group. DECA decreased TGh (p = 0.02) in A group vs. control. Taurine decreased TGh in T (p = 0.004) and AT (p &lt; 0.001) groups vs. control and tended to lower NEFA (p = 0.08) in AT group vs. A group. Neither DECA, nor taurine influenced TC and LDL-C levels. Conclusions: Taurine partially prevented the occurrence of DECA negative effects on lipid profile, suggesting a therapeutic potential in several conditions associated with chronic high levels of plasma androgens, such as endocrine disorders or AAS-abuse.<\/jats:p>","DOI":"10.3390\/medicina55090540","type":"journal-article","created":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T11:23:18Z","timestamp":1566991398000},"page":"540","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Lipid Profile Changes Induced by Chronic Administration of Anabolic Androgenic Steroids and Taurine in Rats"],"prefix":"10.3390","volume":"55","author":[{"given":"A.E.","family":"Rosca","sequence":"first","affiliation":[{"name":"Department of Functional Sciences, Division of Physiology and Neuroscience, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050470 Bucharest, Romania"},{"name":"\u201cVictor Babe\u015f\u201d National Institute of Research-Development in the Pathology Domain, 050096 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camelia Sorina","family":"Stancu","sequence":"additional","affiliation":[{"name":"Department of Lipoproteins and Atherosclerosis, \u201cNicolae Simionescu\u201d Institute of Cellular Biology and Pathology of the Romanian Academy, 030167 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8087-8125","authenticated-orcid":false,"given":"Corin","family":"Badiu","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, \u201cC. I. Parhon\u201d National Institute of Endocrinology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050470 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan Ovidiu","family":"Popescu","sequence":"additional","affiliation":[{"name":"Department of Neurology, \u201cColentina\u201d Clinical Hospital, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 020350 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7794-9930","authenticated-orcid":false,"given":"Radu","family":"Mirica","sequence":"additional","affiliation":[{"name":"Department of Functional Sciences, Division of Physiology and Neuroscience, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050470 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4530-7965","authenticated-orcid":false,"given":"Constantin","family":"C\u0103runtu","sequence":"additional","affiliation":[{"name":"Department of Functional Sciences, Division of Physiology and Neuroscience, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050470 Bucharest, Romania"},{"name":"Department of Dermatology, \u201cProf. N.C. Paulescu\u201d National Institute of Diabetes, Nutrition and Metabolic Diseases, 030167 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serban","family":"Gologan","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, \u201cElias\u201d Emergency Hospital, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 011461 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzana Elena","family":"Voiculescu","sequence":"additional","affiliation":[{"name":"Department of Functional Sciences, Division of Physiology and Neuroscience, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050470 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4302-629X","authenticated-orcid":false,"given":"Ana-Maria","family":"Zagrean","sequence":"additional","affiliation":[{"name":"Department of Functional Sciences, Division of Physiology and Neuroscience, \u201cCarol Davila\u201d University of Medicine and Pharmacy, 050470 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,8,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.annepidem.2014.01.009","article-title":"The global epidemiology of anabolic-androgenic steroid use: A meta-analysis and meta-regression analysis","volume":"24","author":"Sagoe","year":"2014","journal-title":"Ann. 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