{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T17:26:14Z","timestamp":1770744374808,"version":"3.49.0"},"reference-count":31,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T00:00:00Z","timestamp":1571270400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and Objectives: The aim of the study was to determine the association between presences of fatty pancreas (FP) with the features of metabolic syndrome (MeS) in patients with non\u2013alcoholic fatty liver disease (NAFLD) and to establish a new noninvasive scoring system for the prediction of FP in patients with NAFLD. Material and Methods: 143 patients with NAFLD were classified according to FP severity grade into the two groups and evaluated for diagnostic criteria of MeS. All patients underwent sonographic examination with adiposity measurements and the liver biopsy. Liver fibrosis was evaluated semi-quantitatively according to the METAVIR scoring system and using non-invasive markers of hepatic fibrosis. Results: Waist circumference (WC) was predictive for increased risk of FP in NAFLD patients. Elevated fasting plasma glucose, total cholesterol, serum amylase and lipase levels were associated with presence of severe FP (p value = 0.052, p value = 0.007, p value = 0.014; p value = 0.024, respectively). Presence of increased amounts of mesenteric fat was associated with severe FP (p value = 0.013). The results of this study demonstrated highly significant association between NAFLD and presence of FP. The model for predicting the presence of FP was designed with probability value above 6.5. Conclusion: Pancreatic fat accumulation leads to worsening of pancreatic function which in turns exacerbates severity of metabolic syndrome associated with both, NAFLD and NAFPD.<\/jats:p>","DOI":"10.3390\/medicina55100697","type":"journal-article","created":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T11:07:59Z","timestamp":1571310479000},"page":"697","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Ultrasonographic Evaluation of Fatty Pancreas in Serbian Patients with Non Alcoholic Fatty Liver Disease\u2014A Cross Sectional Study"],"prefix":"10.3390","volume":"55","author":[{"given":"Tamara","family":"Milovanovic","sequence":"first","affiliation":[{"name":"School of Medicine, University of Belgrade, 11 000 Belgrade, Serbia"},{"name":"Clinic for Gastroenterology and Hepatology, Clinical Center of Serbia, 11 000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanja","family":"Dragasevic","sequence":"additional","affiliation":[{"name":"Clinic for Gastroenterology and Hepatology, Clinical Center of Serbia, 11 000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milica","family":"Stojkovic Lalosevic","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Belgrade, 11 000 Belgrade, Serbia"},{"name":"Clinic for Gastroenterology and Hepatology, Clinical Center of Serbia, 11 000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanja","family":"Zgradic","sequence":"additional","affiliation":[{"name":"Clinic for Gastroenterology and Hepatology, Clinical Center of Serbia, 11 000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biljana","family":"Milicic","sequence":"additional","affiliation":[{"name":"Institute for Medical Informatics and Biostatistics, School of Dentistry, University of Belgrade, 11 000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor","family":"Dumic","sequence":"additional","affiliation":[{"name":"Division of Hospital Medicine, Mayo Clinic Health System, Eau Claire, WI 54703, USA"},{"name":"Mayo Clinic College of Medicine and Sciences, Rochester, MN 55905, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Kmezic","sequence":"additional","affiliation":[{"name":"Clinic for Abdominal Surgery\u2014First Surgical Clinic, Clinical Center of Serbia, 11 000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6640-234X","authenticated-orcid":false,"given":"Dusan","family":"Saponjski","sequence":"additional","affiliation":[{"name":"Center for Radiology and MRI, Clinical Center of Serbia, 11 000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrija","family":"Antic","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Belgrade, 11 000 Belgrade, Serbia"},{"name":"Clinic for Abdominal Surgery\u2014First Surgical Clinic, Clinical Center of Serbia, 11 000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Velimir","family":"Markovic","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Belgrade, 11 000 Belgrade, Serbia"},{"name":"Clinic for Abdominal Surgery\u2014First Surgical Clinic, Clinical Center of Serbia, 11 000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragan","family":"Popovic","sequence":"additional","affiliation":[{"name":"School of Medicine, University of Belgrade, 11 000 Belgrade, Serbia"},{"name":"Clinic for Gastroenterology and Hepatology, Clinical Center of Serbia, 11 000 Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2019,10,17]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13073-016-0303-2","article-title":"Impact of the gut microbiota on inflammation, obesity, and metabolic disease","volume":"8","author":"Neves","year":"2016","journal-title":"Genome Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s12328-016-0668-1","article-title":"Influence of metabolic syndrome on upper gastrointestinal disease","volume":"9","author":"Sogabe","year":"2016","journal-title":"Clin. J. Gastroenterol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.phrs.2017.03.008","article-title":"Sex- and gender-related prevalence, cardiovascular risk and therapeutic approach in metabolic syndrome: A review of the literature","volume":"120","author":"Pucci","year":"2017","journal-title":"Pharmacol. Res."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Vishram, J.K., Borglykke, A., Andreasen, A.H., Jeppesen, J., Ibsen, H., J\u00f8rgensen, T., Palmieri, L., Giampaoli, S., Donfrancesco, C., and Kee, F. (2014). Impact of age and gender on the prevalence and prognostic importance of the metabolic syndrome and its components in Europeans. The MORGAM Prospective Cohort Project. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0107294"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (2001). Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA, 285, 2486\u20132497.","DOI":"10.1001\/jama.285.19.2486"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1111\/j.1464-5491.2006.01858.x","article-title":"Metabolic syndrome\u2014A new world-wide definition. A Consensus Statement from the International Diabetes Federation","volume":"23","author":"Alberti","year":"2006","journal-title":"Diabet Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1136\/postgradmedj-2016-134546","article-title":"Non-alcoholic fatty pancreas disease","volume":"93","author":"Alempijevic","year":"2017","journal-title":"Postgrad. Med. J."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/cen.12862","article-title":"Nonalcoholic fatty pancreas disease and nonalcoholic fatty liver disease: More than ectopic fat","volume":"83","author":"Mosca","year":"2015","journal-title":"Clin. Endocrinol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ejim.2014.11.007","article-title":"The effect of fatty pancreas on serum glucose parameters in patients with nonalcoholic steatohepatitis","volume":"26","author":"Uygun","year":"2015","journal-title":"Eur. J. Intern. Med."},{"key":"ref_10","doi-asserted-by":"crossref","unstructured":"Ou, H.Y., Wang, C.Y., Yang, Y.C., Chen, M.F., and Chang, C.J. (2013). The association between nonalcoholic fatty pancreas disease and diabetes. PLoS ONE, 8.","DOI":"10.1371\/journal.pone.0062561"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"e000297","DOI":"10.1161\/JAHA.113.000297","article-title":"Enigmatic ectopic fat: Prevalence of nonalcoholic fatty pancreas disease and its associated factors in a Chinese population","volume":"3","author":"Wang","year":"2014","journal-title":"J. Am. Heart Assoc."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"547","DOI":"10.2174\/1871530318666180328111302","article-title":"Non-Alcoholic Fatty Pancreas Disease (NAFPD): A Silent Spectator or the Fifth Component of Metabolic Syndrome? A Literature Review","volume":"18","author":"Romana","year":"2018","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"key":"ref_13","doi-asserted-by":"crossref","unstructured":"American Diabetes Association (2010). Diagnosis and classification of diabetes mellitus. Diabetes Care, 33, S62\u2013S69.","DOI":"10.2337\/dc10-S062"},{"key":"ref_14","doi-asserted-by":"crossref","unstructured":"Soldatovic, I., Vukovic, R., Culafic, D., Gajic, M., and Dimitrijevic-Sreckovic, V. (2016). SiMS Score: Simple Method for Quantifying Metabolic Syndrome. PLoS ONE, 11.","DOI":"10.1371\/journal.pone.0146143"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1590\/S0004-28032014000200009","article-title":"Grading scale of visceral adipose tissue thickness and their relation to the nonalcoholic fatty liver disease","volume":"51","author":"Andrade","year":"2014","journal-title":"Arq. Gastroenterol."},{"key":"ref_16","first-page":"61","article-title":"Perihepatic adipose tissue thickness: A new non-invasive marker of NAFLD?","volume":"18","author":"Lirussi","year":"2009","journal-title":"J. Gastrointestin. Liver Dis."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/sj.ijo.0803201","article-title":"Mesenteric fat thickness as an independent determinant of fatty liver","volume":"30","author":"Liu","year":"2006","journal-title":"Int. J. Obes."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00508-012-0162-9","article-title":"Assessment of metabolic syndrome in patients with primary biliary cirrhosis","volume":"124","author":"Alempijevic","year":"2012","journal-title":"Wien. Klin. Wochenschr."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"11077","DOI":"10.3748\/wjg.v21.i39.11077","article-title":"Liver fibrosis in non-alcoholic fatty liver disease\u2014Diagnostic challenge with prognostic significance","volume":"21","year":"2015","journal-title":"World J. Gastroenterol."},{"key":"ref_20","first-page":"367","article-title":"Lipomatosis of the pancreas in autopsy material and its relation to age and overweight","volume":"86A","author":"Olsen","year":"1978","journal-title":"Acta Pathol. Microbiol. Scand. A"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S0046-8177(84)80294-4","article-title":"Incidence and diagnostic significance of minor pathologic changes in the adult pancreas at autopsy: A systematic study of 112 autopsies in patients without known pancreatic disease","volume":"15","author":"Stamm","year":"1984","journal-title":"Hum. Pathol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.3748\/wjg.15.1869","article-title":"Clinical implications of fatty pancreas: Correlations between fatty pancreas and metabolic syndrome","volume":"15","author":"Lee","year":"2009","journal-title":"World J. Gastroenterol."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1210\/jc.2010-1722","article-title":"Ectopic fat storage in the pancreas, liver, and abdominal fat depots: Impact on \u03b2-cell function in individuals with impaired glucose metabolism","volume":"96","author":"Goossens","year":"2011","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1053\/j.gastro.2016.03.008","article-title":"Biopsy and Noninvasive Methods to Assess Progression of Nonalcoholic Fatty Liver Disease","volume":"150","author":"Bedossa","year":"2016","journal-title":"Gastroenterology"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jceh.2016.08.006","article-title":"Histological Evaluation of Non-alcoholic Fatty Liver Disease and Its Correlation with Different Noninvasive Scoring Systems with Special Reference to Fibrosis: A Single Center Experience","volume":"6","author":"Rath","year":"2016","journal-title":"J. Clin. Exp. Hepatol."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"475","DOI":"10.3748\/wjg.v20.i2.475","article-title":"Limitations of liver biopsy and non-invasive diagnostic tests for the diagnosis of nonalcoholic fatty liver disease\/nonalcoholic steatohepatitis","volume":"20","author":"Sumida","year":"2014","journal-title":"World J. Gastroenterol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1097\/MPA.0b013e3181f6fce2","article-title":"Nonalcoholic fatty liver disease is related to nonalcoholic fatty pancreas disease","volume":"39","author":"Smits","year":"2010","journal-title":"Pancreas"},{"key":"ref_28","doi-asserted-by":"crossref","unstructured":"Lesmana, C.R., Pakasi, L.S., Inggriani, S., Aidawati, M.L., and Lesmana, L.A. (2015). Prevalence of Non-Alcoholic Fatty Pancreas Disease (NAFPD) and its risk factors among adult medical check-up patients in a private hospital: A large cross sectional study. BMC Gastroenterol., 15.","DOI":"10.1186\/s12876-015-0404-1"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"87","DOI":"10.14740\/gr731w","article-title":"Non-Alcoholic Fatty Pancreatic Disease: A Review of Literature","volume":"9","author":"Tariq","year":"2016","journal-title":"Gastroenterol. Res."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1097\/MPA.0b013e3181a9d5af","article-title":"Risk factors for hyperechogenic pancreas on endoscopic ultrasound: A case-control study","volume":"38","author":"Khashab","year":"2009","journal-title":"Pancreas"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1111\/apt.12237","article-title":"Association between novel MRI-estimated pancreatic fat and liver histology-determined steatosis and fibrosis in non-alcoholic fatty liver disease","volume":"37","author":"Patel","year":"2013","journal-title":"Aliment. Pharmacol. Ther."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/55\/10\/697\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:27:11Z","timestamp":1760189231000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/55\/10\/697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,17]]},"references-count":31,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2019,10]]}},"alternative-id":["medicina55100697"],"URL":"https:\/\/doi.org\/10.3390\/medicina55100697","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,17]]}}}