{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:24:20Z","timestamp":1792697060324,"version":"4.5.0"},"reference-count":28,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2019,10,20]],"date-time":"2019-10-20T00:00:00Z","timestamp":1571529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and objective: The incidence of inflammatory bowel disease (IBD) over the past years in Romania has been on the rise, but epidemiologic data are lacking. The aim of this study was to define the characteristics of IBD, the trends and phenotype among IBD patients in Romania. Material and methods: We conducted a prospective study over a period of 12 years, from 2006 to 2017. All patients diagnosed with IBD on clinical, radiological, endoscopic and histological features were included. We divided the country into eight regions: west (W), north-east (NE), north-west (NW), south-east (SE), south-west (SW), south (S), central (C) and Bucharest-Ilfov (B), and data were analyzed accordingly. Results: A total of 2724 patients were included in this database, but only 2248 were included in the final analysis, with all data available. Of the 2248 patients, 935 were Crohn\u2019s disease (CD), 1263 were ulcerative colitis (UC) and 50 were IBD-undetermined. In UC phenotypes we observed more frequent left-sided colitis (50.5%, p &lt; 0.0001), and in CD phenotype we observed more frequent colonic and ileo-colonic localization (37.8% and 37.6%, p &lt; 0.0001). The region with the most IBD cases was NE (25.1%) and with the least IBD cases was SW (4.9%). UC was found more frequently in NE (32%), while CD was found more frequently in Bucharest (28.6%). Conclusions: In Romania, ulcerative colitis is more frequent than CD. UC is predominant in the northern part of Romania, while CD has become predominant in the southern part of the country. IBD occurs more in the male population, and in urban and industrialized areas. There are differences between the regions in Romania regarding IBD phenotypes, gender distributions, age distribution, treatment, smoking status and complications.<\/jats:p>","DOI":"10.3390\/medicina55100704","type":"journal-article","created":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T03:40:29Z","timestamp":1571629229000},"page":"704","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Geographic Distribution, Phenotype and Epidemiological Tendency in Inflammatory Bowel Disease Patients in Romania"],"prefix":"10.3390","volume":"55","author":[{"given":"Adrian","family":"Goldi\u0219","sequence":"first","affiliation":[{"name":"Department of Gastroenterology and Hepatology, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raluca","family":"Lupu\u0219oru","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"},{"name":"Department of Functional Sciences, \u201cVictor Babe\u0219\u201d University of Medicine and Pharmacy, 300041 Timi\u0219oara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liana","family":"Gheorghe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, Fundeni Clinical Institute, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Gheorghe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, Fundeni Clinical Institute, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca","family":"Trifan","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Institute, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700019 Ia\u0219i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Dobru","sequence":"additional","affiliation":[{"name":"Municipal Hospital, Gastroenterology, University of Medicine and Pharmacy, 540139 T\u00e2rgu-Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Cijevschi","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology Institute, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy, 700019 Ia\u0219i, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Tan\u021b\u0103u","sequence":"additional","affiliation":[{"name":"\u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy, 3rd Medical Clinic, 400012 Cluj-Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Constantinescu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, Floreasca Emergency Hospital, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u0103zvan","family":"Iacob","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, Fundeni Clinical Institute, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramona","family":"Goldi\u0219","sequence":"additional","affiliation":[{"name":"Algomed Policlinic, 300041 Timisoara, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mircea","family":"Diculescu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology, \u201cCarol Davila\u201d University of Medicine and Pharmacy, Fundeni Clinical Institute, 020021 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,10,20]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00054725-200501000-00001","article-title":"The IBD international genetics consortium provides further evidence for linkage to IBD4 and shows gene-environment interaction","volume":"11","author":"Pierik","year":"2005","journal-title":"Inflamm. 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