{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:51:22Z","timestamp":1789753882279,"version":"4.0.1"},"reference-count":30,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T00:00:00Z","timestamp":1571875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background and objectives: Ragweed pollen is a major source of allergen, which has rarely been observed in Romania until now. In this study, we evaluated the symptoms and associated factors in patients with allergic rhinitis to ragweed pollen in two distinct regions of Romania. Materials and Methods: We evaluated the records of patients newly diagnosed with allergic rhinitis induced by ragweed pollen in two allergological centers from North-West (NW) and Central parts of Romania between 2013 and 2015. The patients were clinically evaluated regarding disease length, presence, and severity of the allergic rhinitis symptoms and the association with other allergic manifestations (asthma and conjunctivitis). Results: The sensitization to ragweed was significantly higher in the NW part compared to the Central part (18.27% vs 4.1%, p &lt; 0.001). More patients with monosensitization to ragweed pollen were observed in the NE center (27%) compared to the Central one (20.7%). Patients with monosensitization to ragweed pollen presented more severe forms of rhinitis (70% vs 31.5%, p = 0.02) in the NW part compared to polysensitized patients. The total symptoms score was significantly higher in patients from the Central part compared to the NW part (9.21 \u00b1 2.01 vs 5.76 \u00b11.96, p &lt; 0.001). Bronchial asthma was associated at a similar frequency to allergic rhinitis in both centers, but it was more frequently observed in monosensitized patients in the NW center. Allergic conjunctivitis was more frequently reported by patients from the Central part (75.86 vs 41.9, p = 0.02), while in the NW region it was noticed more commonly in monosensitized patients (65% vs 33.33, p = 0.02). Conclusions: Allergic rhinitis to ragweed pollen has been more frequently reported in the NW part of Romania. Patients with severe forms of rhinitis were observed in the central part, while in the NW the severe forms of disease were reported by patients with monosensitization. Ragweed pollen is intensely allergogenic and determines association of ocular and asthma symptoms. Co-sensitization increases the risk of asthma association.<\/jats:p>","DOI":"10.3390\/medicina55110712","type":"journal-article","created":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T04:41:27Z","timestamp":1571978487000},"page":"712","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Characterization of Patients with Allergic Rhinitis to Ragweed Pollen in Two Distinct Regions of Romania"],"prefix":"10.3390","volume":"55","author":[{"given":"Ioana Corina","family":"Bocsan","sequence":"first","affiliation":[{"name":"Department of Pharmacology, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, Toxicology and Clinical Pharmacology, 400337 Cluj Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioana Adriana","family":"Muntean","sequence":"additional","affiliation":[{"name":"Department of Allergology and Immunology, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 400146 Cluj Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corina","family":"Ureche","sequence":"additional","affiliation":[{"name":"First Internal Medical Department, \u201cGeorge Emil Palade\u201d University of Medicine, Pharmacy, Sciences and Technology, 540136 T\u00e2rgu Mure\u0219, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1899-5977","authenticated-orcid":false,"given":"Raluca Maria","family":"Pop","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, Toxicology and Clinical Pharmacology, 400337 Cluj Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Adriana","family":"Neag","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, Toxicology and Clinical Pharmacology, 400337 Cluj Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Octavia","family":"Sabin","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, Toxicology and Clinical Pharmacology, 400337 Cluj Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Deleanu","sequence":"additional","affiliation":[{"name":"Department of Allergology and Immunology, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, 400146 Cluj Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anca Dana","family":"Buzoianu","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, \u201cIuliu Hatieganu\u201d University of Medicine and Pharmacy, Toxicology and Clinical Pharmacology, 400337 Cluj Napoca, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,10,24]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1111\/j.1398-9995.2007.01393.x","article-title":"Allergenic pollen and pollen allergy in Europe","volume":"62","author":"Cecchi","year":"2007","journal-title":"Allergy"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jaci.2015.03.048","article-title":"The allergy epidemics: 1870\u20132010","volume":"136","year":"2015","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1016\/j.jaci.2017.03.050","article-title":"Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines-2016 revision","volume":"140","author":"Bousquet","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1159\/000487997","article-title":"Ragweed Pollen Allergy: Burden, Characteristics, and Management of an Imported Allergen Source in Europe","volume":"176","author":"Chen","year":"2018","journal-title":"Int. Arch. Allergy Immunol."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Storkey, J., Stratonovitch, P., Chapman, D.S., Vidotto, F., and Semenov, M.A. (2014). A process-based approach to predicting the effect of climate change on the distribution of an invasive allergenic plant in Europe. PLoS ONE, 9.","DOI":"10.1371\/journal.pone.0088156"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1111\/j.1398-9995.2009.01975.x","article-title":"Ragweed sensitization in Europe\u2013GA2LEN study suggests increasing prevalence","volume":"64","author":"Burbach","year":"2009","journal-title":"Allergy"},{"key":"ref_7","first-page":"209","article-title":"Ragweed pollen in France: Origin, diffusion, exposure","volume":"42","author":"Thibaudon","year":"2010","journal-title":"Eur. Ann. Allergy Clin. Immunol."},{"key":"ref_8","first-page":"233","article-title":"Estimation of pollen and seed production of common ragweed in France","volume":"14","author":"Fumanal","year":"2007","journal-title":"Ann. Agric. Environ. Med."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1097\/EDE.0b013e31823b66b8","article-title":"Effects of ambient pollen concentrations on frequency and severity of asthma symptoms among asthmatic children","volume":"23","author":"DellaValle","year":"2012","journal-title":"Epidemiology"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.jaci.2013.12.1071","article-title":"Prevalence of allergic sensitization in the United States: Results from the National Health and Nutrition Examination Survey (NHANES) 2005\u20132006","volume":"134","author":"Salo","year":"2014","journal-title":"J. Allergy Clin. Immunol."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Leru, P.M., Eftimie, A.M., Anton, V.F., and Thibaudon, M. (2019). Five-Year Data on Pollen Monitoring, Distribution and Health Impact of Allergenic Plants in Bucharest and the Southeastern Region of Romania. Medicina, 55.","DOI":"10.3390\/medicina55050140"},{"key":"ref_12","first-page":"66","article-title":"The Prevalence of Allergic Rhinitis toAmbrosia Elatior in Oltenia Area and the Association with Allergic Conjunctivitis or Asthma","volume":"45","author":"Popescu","year":"2019","journal-title":"Curr. Health Sci. J."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/2045-7022-3-3","article-title":"The skin prick test\u2014European standards","volume":"3","author":"Heinzerling","year":"2013","journal-title":"Clin. Transl. Allergy"},{"key":"ref_14","first-page":"146","article-title":"Ambrosia artemisiifolia in Romania","volume":"6","author":"Ianovici","year":"2009","journal-title":"J. Rom. Soc. Allergol. Clin. Immunol."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1742","DOI":"10.5586\/aa.1742","article-title":"Modeling hay fever risk factors caused by pollen from Ambrosia spp. using pollen load mapping in Ukraine","volume":"71","author":"Rodinkova","year":"2018","journal-title":"Acta Agrobot."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1007\/s00484-017-1328-y","article-title":"The occurrence of Ambrosia pollen in the atmosphere of Northwest Turkey: Investigation of possible source regions","volume":"61","author":"Celenk","year":"2017","journal-title":"Int. J. Biometeorol."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s10453-016-9463-1","article-title":"Spatial and temporal variations in airborne Ambrosia pollen in Europe","volume":"33","author":"Sikoparija","year":"2017","journal-title":"Aerobiologia"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1515\/biolog-2015-0102","article-title":"Reciprocal contamination by invasive plants: Analysis of trade exchange between Slovakia and Romania","volume":"70","author":"Ferus","year":"2015","journal-title":"Biologia"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s00704-017-2184-8","article-title":"Biogeographical drivers of ragweed pollen concentrations in Europe","volume":"133","author":"Matyasovszky","year":"2018","journal-title":"Theor. Appl. Climatol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1111\/j.1365-2222.2006.02477.x","article-title":"Artemisia and Ambrosia hypersensitivity: Co-sensitization or co-recognition?","volume":"36","author":"Asero","year":"2006","journal-title":"Clin. Exp. Allergy"},{"key":"ref_21","first-page":"70","article-title":"Sensitisation to Ambrosia in Switzerland: A public health threat on the wait","volume":"139","author":"Schindler","year":"2009","journal-title":"Swiss Med. Wkly."},{"key":"ref_22","first-page":"125","article-title":"Airborne ragweed (Ambrosia artemisiifolia L.) pollen content in the city of Zagreb and implications on pollen allergy","volume":"15","author":"Peternel","year":"2008","journal-title":"Ann. Agric. Environ. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.scitotenv.2019.05.284","article-title":"Ragweed pollen and allergic symptoms in children: Results from a three-year longitudinal study","volume":"683","author":"Jones","year":"2019","journal-title":"Sci. Total Environ."},{"key":"ref_24","first-page":"529","article-title":"Changing pattern of sensitization in Croatia to aeroallergens in adult population referring to allergy clinic during a period of 15 years","volume":"35","author":"Vuljanko","year":"2011","journal-title":"Coll. Antropol."},{"key":"ref_25","first-page":"w13253","article-title":"Time lag between Ambrosia sensitisation and Ambrosia allergy: A 20-year study (1989\u20132008) in Legnano, northern Italy","volume":"141","author":"Tosi","year":"2011","journal-title":"Swiss Med. Wkly."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.anai.2010.01.012","article-title":"Factors that affect the allergic rhinitis response to ragweed allergen exposure","volume":"104","author":"Ellis","year":"2010","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"ref_27","first-page":"21","article-title":"In children allergic to ragweed pollen, nasal inflammation is not influenced by monosensitization or polysensitization","volume":"9","author":"Gelardi","year":"2016","journal-title":"J. Inflamm. Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1111\/j.1398-9995.2007.01457.x","article-title":"Prevalence of allergy, patterns of allergic sensitization and allergy risk factors in rural and urban children","volume":"62","author":"Korzon","year":"2007","journal-title":"Allergy"},{"key":"ref_29","first-page":"137","article-title":"Different phenotypes of intermittent and persistent respiratory allergy in Zagreb, Croatia","volume":"16","author":"Vrbica","year":"2009","journal-title":"Ann. Agric. Environ. Med."},{"key":"ref_30","first-page":"1989","article-title":"Characterisctics of ragweed allergy in Hungary","volume":"157","author":"Bikov","year":"2016","journal-title":"Orv. Hetil."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/55\/11\/712\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:29:05Z","timestamp":1760189345000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/55\/11\/712"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,24]]},"references-count":30,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2019,11]]}},"alternative-id":["medicina55110712"],"URL":"https:\/\/doi.org\/10.3390\/medicina55110712","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,24]]}}}