{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T20:45:48Z","timestamp":1792529148242,"version":"4.5.0"},"reference-count":150,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T00:00:00Z","timestamp":1571961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["PDCPN- 2015-01-63"],"award-info":[{"award-number":["PDCPN- 2015-01-63"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["INFR-2014-01-225520"],"award-info":[{"award-number":["INFR-2014-01-225520"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["INFR-2015-01-254106"],"award-info":[{"award-number":["INFR-2015-01-254106"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["SEP-CONACYT-CB-2015-258316"],"award-info":[{"award-number":["SEP-CONACYT-CB-2015-258316"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["SS\/IMSS\/ISSSTE-CONACYT-2016-01-273144"],"award-info":[{"award-number":["SS\/IMSS\/ISSSTE-CONACYT-2016-01-273144"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["Master's degree scholarship 789010"],"award-info":[{"award-number":["Master's degree scholarship 789010"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Diabetic foot ulcers (DFUs) are the fastest growing chronic complication of diabetes mellitus, with more than 400 million people diagnosed globally, and the condition is responsible for lower extremity amputation in 85% of people affected, leading to high-cost hospital care and increased mortality risk. Neuropathy and peripheral arterial disease trigger deformities or trauma, and aggravating factors such as infection and edema are the etiological factors for the development of DFUs. DFUs require identifying the etiology and assessing the co-morbidities to provide the correct therapeutic approach, essential to reducing lower-extremity amputation risk. This review focuses on the current treatment strategies for DFUs with a special emphasis on tissue engineering techniques and regenerative medicine that collectively target all components of chronic wound pathology.<\/jats:p>","DOI":"10.3390\/medicina55110714","type":"journal-article","created":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T11:05:18Z","timestamp":1572001518000},"page":"714","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":170,"title":["Current Therapeutic Strategies in Diabetic Foot Ulcers"],"prefix":"10.3390","volume":"55","author":[{"given":"Aurelio","family":"Perez-Favila","sequence":"first","affiliation":[{"name":"Molecular Medicine Laboratory, Unidad Academica de Medicina Humana y Ciencias de la Salud, Universidad Autonoma de Zacatecas, Carretera Zacatecas-Guadalajara Km.6. Ejido la Escondida, C.P., Zacatecas 98160, Mexico"},{"name":"Posgrado en Ingenieria y Tecnologia Aplicada, Unidad Academica de Ingenieria Electrica, Universidad Autonoma de Zacatecas, Av. Ramon Lopez Velarde No. 801, Col. Centro, C.P., Zacatecas 98000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1478-9068","authenticated-orcid":false,"given":"Margarita L","family":"Martinez-Fierro","sequence":"additional","affiliation":[{"name":"Molecular Medicine Laboratory, Unidad Academica de Medicina Humana y Ciencias de la Salud, Universidad Autonoma de Zacatecas, Carretera Zacatecas-Guadalajara Km.6. Ejido la Escondida, C.P., Zacatecas 98160, Mexico"},{"name":"Posgrado en Ingenieria y Tecnologia Aplicada, Unidad Academica de Ingenieria Electrica, Universidad Autonoma de Zacatecas, Av. Ramon Lopez Velarde No. 801, Col. Centro, C.P., Zacatecas 98000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica G","family":"Rodriguez-Lazalde","sequence":"additional","affiliation":[{"name":"Molecular Medicine Laboratory, Unidad Academica de Medicina Humana y Ciencias de la Salud, Universidad Autonoma de Zacatecas, Carretera Zacatecas-Guadalajara Km.6. Ejido la Escondida, C.P., Zacatecas 98160, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A","family":"Cid-Baez","sequence":"additional","affiliation":[{"name":"Molecular Medicine Laboratory, Unidad Academica de Medicina Humana y Ciencias de la Salud, Universidad Autonoma de Zacatecas, Carretera Zacatecas-Guadalajara Km.6. Ejido la Escondida, C.P., Zacatecas 98160, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle de J","family":"Zamudio-Osuna","sequence":"additional","affiliation":[{"name":"Bioss Celulas Madre, Av. Gomez Morin No. 1200, Carrizalejo, C.P., San Pedro Garza Garcia 66254, Nuevo Leon, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma. del Rosario","family":"Martinez-Blanco","sequence":"additional","affiliation":[{"name":"Posgrado en Ingenieria y Tecnologia Aplicada, Unidad Academica de Ingenieria Electrica, Universidad Autonoma de Zacatecas, Av. Ramon Lopez Velarde No. 801, Col. Centro, C.P., Zacatecas 98000, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana E","family":"Mollinedo-Monta\u00f1o","sequence":"additional","affiliation":[{"name":"Unidad Academica de Enfermeria, Universidad Autonoma de Zacatecas, Carretera Zacatecas-Guadalajara Km.6. Ejido la Escondida, C.P., Zacatecas 98160, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5988-4168","authenticated-orcid":false,"given":"Iram P","family":"Rodriguez-Sanchez","sequence":"additional","affiliation":[{"name":"Laboratorio de Fisiologia Molecular y Estructural, Facultad de Ciencias Biologicas, Universidad Autonoma de Nuevo Leon, C.P., San Nicolas de los Garza 66455, Nuevo Leon, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Casta\u00f1eda-Miranda","sequence":"additional","affiliation":[{"name":"Posgrado en Ingenieria y Tecnologia Aplicada, Unidad Academica de Ingenieria Electrica, Universidad Autonoma de Zacatecas, Av. Ramon Lopez Velarde No. 801, Col. 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Diabetes Care, 32, S62\u2013S67.","DOI":"10.2337\/dc09-S062"},{"key":"ref_2","unstructured":"International Diabetes Federation (2017). IDF Diabetes Atlas, International Diabetes Federation."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/S0300-8932(02)76674-8","article-title":"Epidemiology of diabetes and its non-coronary complications","volume":"55","author":"Goday","year":"2002","journal-title":"Rev. Esp. Cardiol."},{"key":"ref_4","first-page":"58","article-title":"The gold standard in diabetic foot treatment: Total contact cast","volume":"150","year":"2014","journal-title":"Gac. Med. Mex."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1111\/j.1742-481X.2012.01022.x","article-title":"Risk factors for recurrence of diabetic foot ulcers: prospective follow-up analysis in the Eurodiale subgroup","volume":"10","author":"Dubsky","year":"2013","journal-title":"Int. Wound J."},{"key":"ref_6","doi-asserted-by":"crossref","unstructured":"Oguntibeju, O.O. (2013). Diabetes Mellitus in Developing Countries and Case Series, in Diabetes Mellitus\u2014Insights and Perspectives, IntechOpen.","DOI":"10.5772\/3038"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1089\/dia.2014.0004","article-title":"Effect of intensive nursing education on the prevention of diabetic foot ulceration among patients with high-risk diabetic foot: a follow-up analysis","volume":"16","author":"Ren","year":"2014","journal-title":"Diabetes Technol. Ther."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.mcna.2013.03.007","article-title":"The Pathway to Foot Ulceration in diabetes","volume":"97","author":"Boulton","year":"2013","journal-title":"Med. Clin. N. Am."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1 e1","DOI":"10.1016\/j.jaad.2013.06.055","article-title":"Diabetic foot ulcers: Part I","volume":"70","author":"Alavi","year":"2014","journal-title":"Pathophysiology and prevention. J. Am. Acad. Dermatol."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/(SICI)1096-9136(199806)15:6<508::AID-DIA613>3.0.CO;2-L","article-title":"Guidelines for the diagnosis and outpatient management of diabetic peripheral neuropathy","volume":"15","author":"Boulton","year":"1998","journal-title":"Diabet. Med."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.mayocp.2015.05.004","article-title":"Peripheral Neuropathy: A Practical Approach to Diagnosis and Symptom Management","volume":"90","author":"Watson","year":"2015","journal-title":"Mayo Clin. Proc."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"14","DOI":"10.2337\/dc06-1600","article-title":"Preventing diabetic foot ulcer recurrence in high-risk patients: use of temperature monitoring as a self-assessment tool","volume":"30","author":"Lavery","year":"2007","journal-title":"Diabetes Care"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/dom.12422","article-title":"Peripheral arterial disease and revascularization of the diabetic foot","volume":"17","author":"Forsythe","year":"2015","journal-title":"Diabetes Obes. Metab."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1177\/1534734605280130","article-title":"A review of the mechanisms implicated in the pathogenesis of the diabetic foot","volume":"4","author":"Dinh","year":"2005","journal-title":"Int. J. Low Extrem. Wounds"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"e205","DOI":"10.1016\/j.crvasa.2017.07.006","article-title":"Primary media sclerosis M\u00f6nckeberg: Diagnostic criteria","volume":"60","author":"Lanzer","year":"2017","journal-title":"Cor Vasa"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1056\/NEJM198705283162204","article-title":"Compensatory enlargement of human atherosclerotic coronary arteries","volume":"316","author":"Glagov","year":"1987","journal-title":"N. Engl. J. Med."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1111\/j.1574-695X.1999.tb01397.x","article-title":"Immune dysfunction in patients with diabetes mellitus (DM)","volume":"26","author":"Geerlings","year":"1999","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"ref_18","first-page":"187","article-title":"Impaired immune responses in diabetes mellitus: Analysis of the factors and mechanisms involved. Relevance to the increased susceptibility of diabetic patients to specific infections","volume":"18","author":"Moutschen","year":"1992","journal-title":"Diabete Metab."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"2356870","DOI":"10.1155\/2016\/2356870","article-title":"An Alteration of Lymphocytes Subpopulations and Immunoglobulins Levels in Patients with Diabetic Foot Ulcers Infected Particularly by Resistant Pathogens","volume":"2016","author":"Fejfarova","year":"2016","journal-title":"J. Diabetes Res."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1086\/424846","article-title":"Diagnosis and treatment of diabetic foot infections","volume":"39","author":"Lipsky","year":"2004","journal-title":"Clin. Infect. Dis."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1111\/wrr.12056","article-title":"Wound healing potential of topical bacteriophage therapy on diabetic cutaneous wounds","volume":"21","author":"Mendes","year":"2013","journal-title":"Wound Repair. Regen."},{"key":"ref_22","first-page":"37","article-title":"A rat model of diabetic wound infection for the evaluation of topical antimicrobial therapies","volume":"62","author":"Mendes","year":"2012","journal-title":"Comp. Med."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11892-017-0831-1","article-title":"Diabetic Foot Infections: An Update in Diagnosis and Management","volume":"17","author":"Grigoropoulou","year":"2017","journal-title":"Curr. Diabetes Rep."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta10120","article-title":"A series of systematic reviews to inform a decision analysis for sampling and treating infected diabetic foot ulcers","volume":"10","author":"Nelson","year":"2006","journal-title":"Health Technol. Assess."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/microbiolspec.DMIH2-0014-2015","article-title":"Diagnostic microbiology of the immunocompromised host: skin and soft tissue infection","volume":"4","author":"Moffarah","year":"2016","journal-title":"Microbiol Spectrum."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1007\/s00248-016-0867-9","article-title":"Bacterial Contribution in Chronicity of Wounds","volume":"73","author":"Rahim","year":"2017","journal-title":"Microb. Ecol."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.yexcr.2004.10.033","article-title":"Cellular and molecular facets of keratinocyte reepithelization during wound healing","volume":"304","author":"Santoro","year":"2005","journal-title":"Exp. Cell Res."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1159\/000081919","article-title":"Coagulation and fibrinolysis parameters in type 2 diabetic patients with and without diabetic vascular complications","volume":"14","author":"Erem","year":"2005","journal-title":"Med. Princ. Pract."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1007\/s12663-016-0880-z","article-title":"Wound Healing Concepts in Clinical Practice of OMFS","volume":"16","author":"Chhabra","year":"2017","journal-title":"J. Maxillofac. Oral Surg."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1152\/physrev.2003.83.3.835","article-title":"Regulation of wound healing by growth factors and cytokines","volume":"83","author":"Werner","year":"2003","journal-title":"Physiol. Rev."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"920613","DOI":"10.1155\/2014\/920613","article-title":"Cytokines and diabetes research","volume":"2014","author":"Xiao","year":"2014","journal-title":"J. Diabetes Res."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"e2","DOI":"10.1017\/S1462399409000945","article-title":"Inflammation and neuropeptides: The connection in diabetic wound healing","volume":"11","author":"Pradhan","year":"2009","journal-title":"Expert Rev. Mol. Med."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/S0140-6736(05)67700-8","article-title":"Wound healing and its impairment in the diabetic foot","volume":"366","author":"Falanga","year":"2005","journal-title":"Lancet"},{"key":"ref_34","first-page":"1103","article-title":"Hyperglycaemic conditions decrease cultured keratinocyte mobility: Implications for impaired wound healing in patients with diabetes","volume":"159","author":"Lan","year":"2008","journal-title":"Br. J. Dermatol."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1016\/S0002-9440(10)63754-6","article-title":"Topical vascular endothelial growth factor accelerates diabetic wound healing through increased angiogenesis and by mobilizing and recruiting bone marrow-derived cells","volume":"164","author":"Galiano","year":"2004","journal-title":"Am. J. Pathol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"461","DOI":"10.2337\/diacare.28.2.461","article-title":"Proteases and the diabetic foot syndrome: Mechanisms and therapeutic implications","volume":"28","author":"Lobmann","year":"2005","journal-title":"Diabetes Care"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1111\/wrr.12437","article-title":"Altered ECM deposition by diabetic foot ulcer-derived fibroblasts implicates fibronectin in chronic wound repair","volume":"24","author":"Maione","year":"2016","journal-title":"Wound Repair Regen."},{"key":"ref_38","doi-asserted-by":"crossref","unstructured":"Wang, C., Mai, L., Yang, C., Liu, D., Sun, K., Song, W., Luo, B., Li, Y., Xu, M., and Zhang, S. (2016). Reducing major lower extremity amputations after the introduction of a multidisciplinary team in patient with diabetes foot ulcer. BMC Endocr. Disord., 16.","DOI":"10.1186\/s12902-016-0111-0"},{"key":"ref_39","doi-asserted-by":"crossref","unstructured":"Blakely, M. (2016). The Use of Best Practice in the Treatment of a Complex Diabetic Foot Ulcer: A Case Report. Healthcare (Basel), 4.","DOI":"10.3390\/healthcare4010018"},{"key":"ref_40","first-page":"65","article-title":"Foot ulcers in the diabetic patient, prevention and treatment","volume":"3","author":"Wu","year":"2007","journal-title":"Vasc. Health Risk Manag."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"1S","DOI":"10.1016\/S0002-9610(03)00299-X","article-title":"Protocol for treatment of diabetic foot ulcers","volume":"187","author":"Brem","year":"2004","journal-title":"Am. J. Surg."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/dmrr.2740","article-title":"The diabetic foot in 2015: An overview","volume":"32","author":"Markakis","year":"2016","journal-title":"Diabetes Metab. Res. Rev."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1210\/en.2019-00311","article-title":"Understanding the Signaling Pathways Related to the Mechanism and Treatment of Diabetic Peripheral Neuropathy","volume":"160","author":"Tang","year":"2019","journal-title":"Endocrinology."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1056\/NEJM199004123221503","article-title":"Effects of pancreatic transplantation on diabetic neuropathy","volume":"322","author":"Kennedy","year":"1990","journal-title":"N. Engl. J. Med."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"672","DOI":"10.4140\/TCP.n.2013.672","article-title":"Tapentadol-ER for the treatment of diabetic peripheral neuropathy","volume":"28","author":"Games","year":"2013","journal-title":"Consult. Pharm."},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"1113\u2013e88","DOI":"10.1111\/j.1468-1331.2010.02999.x","article-title":"EFNS guidelines on the pharmacological treatment of neuropathic pain: 2010 revision","volume":"17","author":"Attal","year":"2010","journal-title":"Eur. J. Neurol."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1111\/dom.12535","article-title":"Burning through the pain: Treatments for diabetic neuropathy","volume":"17","author":"Javed","year":"2015","journal-title":"Diabetes Obes. Metab."},{"key":"ref_48","first-page":"786","article-title":"Alpha-Lipoic Acid for Treatment of Diabetic Peripheral Neuropathy","volume":"93","author":"Bartkoski","year":"2016","journal-title":"Am. Fam. Physician"},{"key":"ref_49","doi-asserted-by":"crossref","unstructured":"Oses, C., Olivares, B., Ezquer, M., Acosta, C., Bosch, P., Donoso, M., Leniz, P., and Ezquer, F. (2017). Preconditioning of adipose tissue-derived mesenchymal stem cells with deferoxamine increases the production of pro-angiogenic, neuroprotective and anti-inflammatory factors: Potential application in the treatment of diabetic neuropathy. PLoS ONE, 12.","DOI":"10.1371\/journal.pone.0178011"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"89","DOI":"10.3389\/fendo.2017.00089","article-title":"Low-Dose Pulsatile Interleukin-6 As a Treatment Option for Diabetic Peripheral Neuropathy","volume":"8","author":"Cox","year":"2017","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.pain.2007.08.033","article-title":"Pharmacologic management of neuropathic pain: Evidence-based recommendations","volume":"132","author":"Dworkin","year":"2007","journal-title":"Pain"},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1097\/AJP.0000000000000254","article-title":"Pregabalin in Patients With Painful Diabetic Peripheral Neuropathy Using an NSAID for Other Pain Conditions: A Double-Blind Crossover Study","volume":"32","author":"Raskin","year":"2016","journal-title":"Clin. J. Pain"},{"key":"ref_53","first-page":"173","article-title":"The angiosome model in the revascularization strategy of critical limb ischemia","volume":"64","year":"2012","journal-title":"Angiolog\u00eda"},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.jamcollsurg.2010.12.027","article-title":"Contemporary management of diabetic neuropathic foot ulceration: A study of 917 consecutively treated limbs","volume":"212","author":"Taylor","year":"2011","journal-title":"J. Am. Coll. Surg."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.jvs.2011.08.014","article-title":"Long-term results of direct and indirect endovascular revascularization based on the angiosome concept in patients with critical limb ischemia presenting with isolated below-the-knee lesions","volume":"55","author":"Iida","year":"2012","journal-title":"J. Vasc. Surg."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1089\/ten.tec.2013.0335","article-title":"Design and fabrication of human skin by three-dimensional bioprinting","volume":"20","author":"Lee","year":"2014","journal-title":"Tissue Eng. Part C Methods"},{"key":"ref_57","doi-asserted-by":"crossref","unstructured":"Bachoo, P. (2010). Endovascular stents for intermittent claudication. Cochrane Database Syst. Rev., CD003228.","DOI":"10.1002\/14651858.CD003228.pub2"},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.ijcard.2016.12.116","article-title":"Efficacy and safety of everolimus and zotarolimus-eluting stents versus first-generation drug-eluting stents in patients with diabetes: A meta-analysis of randomized trials","volume":"230","author":"Bavishi","year":"2017","journal-title":"Int. J. Cardiol."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Kayssi, A., Al-Atassi, T., Oreopoulos, G., Roche-Nagle, G., Tan, K.T., and Rajan, D.K. (2016). Drug-eluting balloon angioplasty versus uncoated balloon angioplasty for peripheral arterial disease of the lower limbs. Cochrane Database Syst. Rev., CD011319.","DOI":"10.1002\/14651858.CD011319.pub2"},{"key":"ref_60","first-page":"1","article-title":"Graft type for femoro-popliteal bypass surgery","volume":"2","author":"Ambler","year":"2018","journal-title":"Cochrane Database Syst Rev."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.jvs.2005.05.031","article-title":"Meta-analysis of alternate autologous vein bypass grafts to infrapopliteal arteries","volume":"42","author":"Albers","year":"2005","journal-title":"J. Vasc. Surg."},{"key":"ref_62","first-page":"133","article-title":"Platelet antiaggregants: Mechanisms of action and use asocied risks","volume":"16","author":"Palomo","year":"2008","journal-title":"Vitae Revista Facultad de Qu\u00edmica Farmac\u00e9utica"},{"key":"ref_63","doi-asserted-by":"crossref","unstructured":"Nicolai, S.P., Kruidenier, L.M., Bendermacher, B.L., Prins, M.H., Stokmans, R.A., Broos, P.P., and Teijink, J.A. (2013). Ginkgo biloba for intermittent claudication. Cochrane Database Syst. Rev., CD006888.","DOI":"10.1002\/14651858.CD006888.pub3"},{"key":"ref_64","first-page":"1","article-title":"Vitamin E for intermittent claudication","volume":"2","author":"Kleijnen","year":"2000","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/1358863X12467491","article-title":"A systematic review and meta-analysis of propionyl-L-carnitine effects on exercise performance in patients with claudication","volume":"18","author":"Brass","year":"2013","journal-title":"Vasc. Med."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.atherosclerosis.2013.03.004","article-title":"A systematic review to evaluate the effectiveness of carnitine supplementation in improving walking performance among individuals with intermittent claudication","volume":"229","author":"Delaney","year":"2013","journal-title":"Atherosclerosis"},{"key":"ref_67","doi-asserted-by":"crossref","unstructured":"Paravastu, S.C., Mendonca, D.A., and Da Silva, A. (2013). Beta blockers for peripheral arterial disease. Cochrane Database Syst. Rev., CD005508.","DOI":"10.1002\/14651858.CD005508.pub3"},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Bedenis, R., Stewart, M., Cleanthis, M., Robless, P., Mikhailidis, D.P., and Stansby, G. (2014). Cilostazol for intermittent claudication. Cochrane Database Syst. Rev., CD003748.","DOI":"10.1002\/14651858.CD003748.pub4"},{"key":"ref_69","unstructured":"Lauvrak, V., Fronsdal, K.B., Ormstad, S.S., Vaagbo, G., and Fure, B. (2015). Effectiveness of Hyperbaric Oxygen Therapy in Patients with Late Radiation Tissue Injury or Diabetic Foot Ulcer, The Norwegian Institute of Public Health."},{"key":"ref_70","doi-asserted-by":"crossref","unstructured":"Liu, J., Zhang, P., Tian, J., Li, L., Li, J., Tian, J.H., and Yang, K. (2015). Ozone therapy for treating foot ulcers in people with diabetes. Cochrane Database Syst. Rev., CD008474.","DOI":"10.1002\/14651858.CD008474.pub2"},{"key":"ref_71","doi-asserted-by":"crossref","unstructured":"Ubbink, D.T., and Vermeulen, H. (2013). Spinal cord stimulation for non-reconstructable chronic critical leg ischaemia. Cochrane Database Syst. Rev., CD004001.","DOI":"10.1002\/14651858.CD004001.pub3"},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta13170","article-title":"Spinal cord stimulation for chronic pain of neuropathic or ischaemic origin: systematic review and economic evaluation","volume":"13","author":"Simpson","year":"2009","journal-title":"Health Technol. Assess."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S0123-9392(10)70093-X","article-title":"P\u00e9ptidos antimicrobianos-Antimicrobial peptides","volume":"14","year":"2010","journal-title":"Infectio"},{"key":"ref_74","doi-asserted-by":"crossref","unstructured":"Gomes, A., Teixeira, C., Ferraz, R., Prudencio, C., and Gomes, P. (2017). Wound-Healing Peptides for Treatment of Chronic Diabetic Foot Ulcers and Other Infected Skin Injuries. Molecules, 22.","DOI":"10.3390\/molecules22101743"},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1002\/dmrr.2698","article-title":"IWGDF guidance on the diagnosis, prognosis and management of peripheral artery disease in patients with foot ulcers in diabetes","volume":"32","author":"Hinchliffe","year":"2016","journal-title":"Diabetes Metab. Res. Rev."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/dmrr.2705","article-title":"Effectiveness of revascularization of the ulcerated foot in patients with diabetes and peripheral artery disease: a systematic review","volume":"32","author":"Hinchliffe","year":"2016","journal-title":"Diabetes Metab. Res. Rev."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2147\/VHRM.S125065","article-title":"Critical limb ischemia: Current challenges and future prospects","volume":"14","author":"Uccioli","year":"2018","journal-title":"Vasc. Health Risk Manag."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0741-5214(95)70279-2","article-title":"Dorsalis pedis arterial bypass: Durable limb salvage for foot ischemia in patients with diabetes mellitus","volume":"21","author":"Pomposelli","year":"1995","journal-title":"J. Vasc. Surg."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s40520-017-0760-5","article-title":"Endovascular treatment of diabetic peripheral arterial disease in older and oldest old patients: A retrospective study","volume":"30","author":"Gatti","year":"2017","journal-title":"Aging Clin. Exp. Res."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"3S","DOI":"10.1016\/j.jvs.2015.10.003","article-title":"The management of diabetic foot: A clinical practice guideline by the Society for Vascular Surgery in collaboration with the American Podiatric Medical Association and the Society for Vascular Medicine","volume":"63","author":"Hingorani","year":"2016","journal-title":"J. Vasc. Surg."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1111\/j.1524-475X.2006.00176.x","article-title":"Guidelines for the treatment of diabetic ulcers","volume":"14","author":"Steed","year":"2006","journal-title":"Wound Repair Regen."},{"key":"ref_82","first-page":"1","article-title":"Hydrogel dressings for healing diabetic foot ulcers","volume":"7","author":"Dumville","year":"2013","journal-title":"Cochrane Database Syst Rev."},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"37563","DOI":"10.1021\/acsami.7b09395","article-title":"pH and Glucose Dual-Responsive Injectable Hydrogels with Insulin and Fibroblasts as Bioactive Dressings for Diabetic Wound Healing","volume":"9","author":"Zhao","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_84","first-page":"1","article-title":"Hydrocolloid dressings for healing diabetic foot ulcers","volume":"8","author":"Dumville","year":"2013","journal-title":"Cochrane Database Syst Rev."},{"key":"ref_85","unstructured":"Registered Nurses\u2019 Association of Ontario (2013). Assessment and Management of Foot Ulcers for People with Diabetes, Registered Nurses\u2019 Association of Ontario. [2nd ed.]."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.2337\/diacare.24.7.1270","article-title":"Plantar tissue thickness is related to peak plantar pressure in the high-risk diabetic foot","volume":"24","author":"Abouaesha","year":"2001","journal-title":"Diabetes Care"},{"key":"ref_87","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1016\/j.burns.2017.07.025","article-title":"Eschar removal by bromelain based enzymatic debridement (Nexobrid(R)) in burns: An European consensus","volume":"43","author":"Hirche","year":"2017","journal-title":"Burns"},{"key":"ref_88","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/S1067-2516(07)60001-5","article-title":"Diabetic foot disorders. A clinical practice guideline (2006 revision)","volume":"45","author":"Frykberg","year":"2006","journal-title":"J. Foot Ankle Surg."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"466","DOI":"10.7547\/87507315-87-10-466","article-title":"1997 William J. Stickel Bronze Award. Comparison of strategies for reducing pressure at the site of neuropathic ulcers","volume":"87","author":"Fleischli","year":"1997","journal-title":"J. Am. Podiatr. Med. Assoc."},{"key":"ref_90","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1177\/1071100716643429","article-title":"Comparison of Removable and Irremovable Walking Boot to Total Contact Casting in Offloading the Neuropathic Diabetic Foot Ulceration","volume":"37","author":"Piaggesi","year":"2016","journal-title":"Foot Ankle Int."},{"key":"ref_91","unstructured":"Health Quality Ontario (2017). Fibreglass Total Contact Casting, Removable Cast Walkers, and Irremovable Cast Walkers to Treat Diabetic Neuropathic Foot Ulcers: A Health Technology Assessment. Ont. Health Technol. Assess. Ser., 17, 1\u2013124."},{"key":"ref_92","unstructured":"Fish, D.N., Taylor, S., and Thoennes, M.J. (2016). Diabetic Foot Infections. Infection Primary Care, Army Center for Substance Abuse Programs."},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"647","DOI":"10.4103\/ijem.IJEM_481_17","article-title":"Choices and Challenges of Antibiotics Therapy in Diabetic Foot Infection","volume":"21","author":"Singh","year":"2017","journal-title":"Indian J. Endocrinol. Metab."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2165\/00128071-200203010-00001","article-title":"Impact of increasing antimicrobial resistance on wound management","volume":"3","author":"Filius","year":"2002","journal-title":"Am. J. Clin. Dermatol."},{"key":"ref_95","first-page":"15","article-title":"Carbapenem resistance: Overview of the problem and future perspectives","volume":"3","author":"Meletis","year":"2016","journal-title":"Ther. Adv. Infect. Dis."},{"key":"ref_96","doi-asserted-by":"crossref","unstructured":"Limoli, D.H., Rockel, A.B., Host, K.M., Jha, A., Kopp, B.T., Hollis, T., and Wozniak, D.J. (2014). Cationic antimicrobial peptides promote microbial mutagenesis and pathoadaptation in chronic infections. PLoS Pathog., 10.","DOI":"10.1371\/journal.ppat.1004083"},{"key":"ref_97","doi-asserted-by":"crossref","unstructured":"Carter, V., Underhill, A., Baber, I., Sylla, L., Baby, M., Larget-Thiery, I., Zettor, A., Bourgouin, C., Langel, U., and Faye, I. (2013). Killer bee molecules: antimicrobial peptides as effector molecules to target sporogonic stages of Plasmodium. PLoS Pathog., 9.","DOI":"10.1371\/journal.ppat.1003790"},{"key":"ref_98","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/iej.12002","article-title":"Antimicrobial efficacy of a human beta-defensin-3 peptide using an Enterococcus faecalis dentine infection model","volume":"46","author":"Lee","year":"2013","journal-title":"Int. Endod. J."},{"key":"ref_99","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1099\/jmm.0.000329","article-title":"Guar gum as a new antimicrobial peptide delivery system against diabetic foot ulcers Staphylococcus aureus isolates","volume":"65","author":"Santos","year":"2016","journal-title":"J. Med. Microbiol."},{"key":"ref_100","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s00284-014-0519-6","article-title":"Antibiofilm and antimicrobial efficacy of DispersinB(R)-KSL-W peptide-based wound gel against chronic wound infection associated bacteria","volume":"68","author":"Gawande","year":"2014","journal-title":"Curr. Microbiol."},{"key":"ref_101","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1007\/s00259-012-2327-1","article-title":"Utility of (9)(9)mTc-labelled antimicrobial peptide ubiquicidin (29-41) in the diagnosis of diabetic foot infection","volume":"40","author":"Saeed","year":"2013","journal-title":"Eur. J. Nucl. Med. Mol. Imaging"},{"key":"ref_102","first-page":"133","article-title":"Expression of natural antimicrobial peptide beta-defensin-2 and Langerhans cell accumulation in epidermis from human non-healing leg ulcers","volume":"43","author":"Galkowska","year":"2005","journal-title":"Folia Histochem. Cytobiol."},{"key":"ref_103","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1086\/593185","article-title":"Topical versus systemic antimicrobial therapy for treating mildly infected diabetic foot ulcers: a randomized, controlled, double-blinded, multicenter trial of pexiganan cream","volume":"47","author":"Lipsky","year":"2008","journal-title":"Clin. Infect. Dis."},{"key":"ref_104","doi-asserted-by":"crossref","first-page":"446","DOI":"10.2337\/diacare.26.2.446","article-title":"Maggot therapy for treating diabetic foot ulcers unresponsive to conventional therapy","volume":"26","author":"Sherman","year":"2003","journal-title":"Diabetes Care"},{"key":"ref_105","first-page":"125","article-title":"The using of Lucilia cuprina maggots in the treatment of diabetic foot wounds","volume":"44","author":"Hassan","year":"2014","journal-title":"J. Egypt Soc. Parasitol."},{"key":"ref_106","doi-asserted-by":"crossref","first-page":"78","DOI":"10.12968\/jowc.2012.21.2.78","article-title":"The use of maggot debridement therapy in the treatment of chronic wounds in hospitalised and ambulatory patients","volume":"21","author":"Gilead","year":"2012","journal-title":"J. Wound Care"},{"key":"ref_107","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1089\/pho.2018.4455","article-title":"Effects of Low-Power Light Therapy on the Tissue Repair Process of Chronic Wounds in Diabetic Feet","volume":"36","author":"Campelo","year":"2018","journal-title":"Photomed. Laser Surg."},{"key":"ref_108","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1089\/pho.2009.2680","article-title":"A randomized clinical trial on the effect of low-level laser therapy on chronic diabetic foot wound healing: a preliminary report","volume":"29","author":"Kaviani","year":"2011","journal-title":"Photomed. Laser Surg."},{"key":"ref_109","first-page":"57","article-title":"Tissue engineering and regenerative medicine: semantic considerations for an evolving paradigm","volume":"2","author":"Katari","year":"2014","journal-title":"Front. Bioeng. Biotechnol."},{"key":"ref_110","doi-asserted-by":"crossref","first-page":"290","DOI":"10.2337\/diacare.24.2.290","article-title":"Graftskin, a human skin equivalent, is effective in the management of noninfected neuropathic diabetic foot ulcers: a prospective randomized multicenter clinical trial","volume":"24","author":"Veves","year":"2001","journal-title":"Diabetes Care"},{"key":"ref_111","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.bjorl.2015.09.011","article-title":"The influence of growth factors on skin wound healing in rats","volume":"82","author":"Campos","year":"2016","journal-title":"Braz. J. Otorhinolaryngol."},{"key":"ref_112","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1097\/01.sap.0000198731.12407.0c","article-title":"Recombinant human epidermal growth factor (EGF) to enhance healing for diabetic foot ulcers","volume":"56","author":"Hong","year":"2006","journal-title":"Ann. Plast Surg."},{"key":"ref_113","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1042\/bj2470385","article-title":"Epidermal growth factor increases collagen production in granulation tissue by stimulation of fibroblast proliferation and not by activation of procollagen genes","volume":"247","author":"Laato","year":"1987","journal-title":"Biochem. J."},{"key":"ref_114","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1042\/BST0330413","article-title":"Harnessing wound healing and regeneration for tissue engineering","volume":"33","author":"Metcalfe","year":"2005","journal-title":"Biochem. Soc. Trans."},{"key":"ref_115","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.actbio.2017.11.045","article-title":"Effects of structurally stabilized EGF and bFGF on wound healing in type I and type II diabetic mice","volume":"66","author":"Choi","year":"2017","journal-title":"Acta Biomater."},{"key":"ref_116","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1111\/bcp.13470","article-title":"Growth factors for diabetic foot ulcers: Mixed treatment comparison analysis of randomized clinical trials","volume":"84","author":"Sridharan","year":"2017","journal-title":"Br. J. Clin. Pharmacol."},{"key":"ref_117","doi-asserted-by":"crossref","first-page":"17","DOI":"10.7547\/15-056","article-title":"An Assessment of Intralesional Epidermal Growth Factor for Treating Diabetic Foot WoundsThe First Experiences in Turkey","volume":"107","author":"Ertugrul","year":"2017","journal-title":"J. Am. Podiatr. Med. Assoc."},{"key":"ref_118","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1080\/15476278.2015.1126018","article-title":"Mesenchymal stem cells: Potential for therapy and treatment of chronic non-healing skin wounds","volume":"11","author":"Marfia","year":"2015","journal-title":"Organogenesis"},{"key":"ref_119","doi-asserted-by":"crossref","first-page":"9328347","DOI":"10.1155\/2017\/9328347","article-title":"Mesenchymal Stem Cells Improve Healing of Diabetic Foot Ulcer","volume":"2017","author":"Cao","year":"2017","journal-title":"J. Diabetes Res."},{"key":"ref_120","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12967-017-1145-4","article-title":"Exendin-4 in combination with adipose-derived stem cells promotes angiogenesis and improves diabetic wound healing","volume":"15","author":"Seo","year":"2017","journal-title":"J. Transl. Med."},{"key":"ref_121","doi-asserted-by":"crossref","first-page":"242\u2013e53","DOI":"10.1111\/vde.12011","article-title":"The effects of topical mesenchymal stem cell transplantation in canine experimental cutaneous wounds","volume":"24","author":"Kim","year":"2013","journal-title":"Vet. Dermatol."},{"key":"ref_122","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1111\/j.1524-4725.2009.01239.x","article-title":"Efficacy and safety of fresh fibroblast allografts in the treatment of diabetic foot ulcers","volume":"35","author":"Han","year":"2009","journal-title":"Dermatol. Surg."},{"key":"ref_123","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/sj.jid.5700786","article-title":"Keratinocyte-fibroblast interactions in wound healing","volume":"127","author":"Werner","year":"2007","journal-title":"J. Invest. Dermatol."},{"key":"ref_124","doi-asserted-by":"crossref","first-page":"5322","DOI":"10.1007\/s10856-014-5322-1","article-title":"Decellularized scaffolds containing hyaluronic acid and EGF for promoting the recovery of skin wounds","volume":"26","author":"Wu","year":"2015","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_125","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1111\/wrr.12234","article-title":"Thrombin as important factor for cutaneous wound healing: comparison of fibrin biomatrices in vitro and in a rat excisional wound healing model","volume":"22","author":"Gugerell","year":"2014","journal-title":"Wound Repair Regen."},{"key":"ref_126","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/wrr.12618","article-title":"In vitro and in vivo investigation of a novel amniotic-based chitosan dressing for wound healing","volume":"26","author":"Momeni","year":"2018","journal-title":"Wound Repair Regen."},{"key":"ref_127","doi-asserted-by":"crossref","first-page":"2890","DOI":"10.3390\/md13052890","article-title":"Alginate hydrogels coated with chitosan for wound dressing","volume":"13","author":"Straccia","year":"2015","journal-title":"Mar. Drugs"},{"key":"ref_128","doi-asserted-by":"crossref","first-page":"015002","DOI":"10.1088\/1748-605X\/aa8439","article-title":"Development of poly (1,8 octanediol-co-citrate) and poly (acrylic acid) nanofibrous scaffolds for wound healing applications","volume":"13","author":"Goins","year":"2017","journal-title":"Biomed. Mater."},{"key":"ref_129","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1177\/0194599816660072","article-title":"Effects of Covering Surgical Wounds with Polyglycolic Acid Sheets for Posttonsillectomy Pain","volume":"155","author":"Miyaguchi","year":"2016","journal-title":"Otolaryngol. Head Neck Surg."},{"key":"ref_130","doi-asserted-by":"crossref","first-page":"3035","DOI":"10.1002\/adhm.201600658","article-title":"Hyaluronic Acid\/PLGA Core\/Shell Fiber Matrices Loaded with EGCG Beneficial to Diabetic Wound Healing","volume":"5","author":"Shin","year":"2016","journal-title":"Adv. Healthc. Mater."},{"key":"ref_131","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.actbio.2007.01.002","article-title":"Evaluation of electrospun PCL\/gelatin nanofibrous scaffold for wound healing and layered dermal reconstitution","volume":"3","author":"Chong","year":"2007","journal-title":"Acta Biomater."},{"key":"ref_132","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.1002\/jbm.a.36177","article-title":"Alkaline poly(ethylene glycol)-based hydrogels for a potential use as bioactive wound dressings","volume":"105","author":"Koehler","year":"2017","journal-title":"J. Biomed. Mater. Res. A"},{"key":"ref_133","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.ijbiomac.2017.07.067","article-title":"Fabrication of bi-layer scaffold of keratin nanofiber and gelatin-methacrylate hydrogel: Implications for skin graft","volume":"105","author":"Kim","year":"2017","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_134","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.jss.2017.04.032","article-title":"Adipose-derived stem cells seeded in Pluronic F-127 hydrogel promotes diabetic wound healing","volume":"217","author":"Kaisang","year":"2017","journal-title":"J. Surg. Res."},{"key":"ref_135","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.12968\/jowc.2016.25.Sup7.S18","article-title":"Evaluation of tissue engineering products for the management of neuropathic diabetic foot ulcers: an interim analysis","volume":"25","author":"Frykberg","year":"2016","journal-title":"J. Wound Care"},{"key":"ref_136","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1046\/j.1523-1747.2002.01865.x","article-title":"Wounding of bioengineered skin: Cellular and molecular aspects after injury","volume":"119","author":"Falanga","year":"2002","journal-title":"J. Invest. Dermatol."},{"key":"ref_137","first-page":"197","article-title":"Cost Effectiveness of Becaplermin Gel on Wound Closure for the Treatment of Pressure Injuries","volume":"30","author":"Gilligan","year":"2018","journal-title":"Wounds"},{"key":"ref_138","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/0305-4179(95)93866-I","article-title":"Use of an acellular allograft dermal matrix (AlloDerm) in the management of full-thickness burns","volume":"21","author":"Wainwright","year":"1995","journal-title":"Burns"},{"key":"ref_139","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1089\/wound.2011.0282","article-title":"Dermagraft: Use in the Treatment of Chronic Wounds","volume":"1","author":"Hart","year":"2012","journal-title":"Adv. Wound Care (New Rochelle)"},{"key":"ref_140","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.cpm.2018.02.006","article-title":"Randomized, Prospective, Blinded-Enrollment, Head-To-Head Venous Leg Ulcer Healing Trial Comparing Living, Bioengineered Skin Graft Substitute (Apligraf) with Living, Cryopreserved, Human Skin Allograft (TheraSkin)","volume":"35","author":"Towler","year":"2018","journal-title":"Clin. Podiatr. Med. Surg."},{"key":"ref_141","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0305-4179(03)00164-5","article-title":"The use of a collagen sponge\/living cell composite material to treat donor sites in burn patients","volume":"29","author":"Still","year":"2003","journal-title":"Burns"},{"key":"ref_142","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0305-4179(99)00143-6","article-title":"Cultured epithelial autografts in extensive burn coverage of severely traumatized patients: a five year single-center experience with 30 patients","volume":"26","author":"Carsin","year":"2000","journal-title":"Burns"},{"key":"ref_143","first-page":"e30","article-title":"Evolution of a Biosynthetic Temporary Skin Substitute: A Preliminary Study","volume":"15","author":"Woodroof","year":"2015","journal-title":"Eplasty"},{"key":"ref_144","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/jbm.b.33813","article-title":"In vivo biocompatibility, vascularization, and incorporation of Integra((R)) dermal regenerative template and flowable wound matrix","volume":"106","author":"Spater","year":"2018","journal-title":"J. Biomed. Mater. Res. B Appl. Biomater."},{"key":"ref_145","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1111\/j.1445-1433.2004.03106.x","article-title":"Treatment of partial-thickness burns: a prospective, randomized trial using Transcyte","volume":"74","author":"Kumar","year":"2004","journal-title":"ANZ J. Surg."},{"key":"ref_146","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.12968\/bjon.2001.10.22.9333","article-title":"Oasis: An innovative alternative dressing for chronic wounds","volume":"10","author":"Benbow","year":"2001","journal-title":"Br. J. Nurs."},{"key":"ref_147","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1177\/000313481307900522","article-title":"Single-institution outcome experience using AlloDerm(R) as temporary coverage or definitive reconstruction for cutaneous and soft tissue malignancy defects","volume":"79","author":"Deneve","year":"2013","journal-title":"Am. Surg."},{"key":"ref_148","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1097\/PRS.0b013e3181904bff","article-title":"AlloDerm versus DermaMatrix in immediate expander-based breast reconstruction: A preliminary comparison of complication profiles and material compliance","volume":"123","author":"Becker","year":"2009","journal-title":"Plast. Reconstr. Surg."},{"key":"ref_149","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.2106\/JBJS.E.01307","article-title":"Commercial extracellular matrix scaffolds for rotator cuff tendon repair. Biomechanical, biochemical, and cellular properties","volume":"88","author":"Derwin","year":"2006","journal-title":"J. Bone Joint Surg. Am."},{"key":"ref_150","doi-asserted-by":"crossref","first-page":"219","DOI":"10.12968\/jowc.2002.11.6.26408","article-title":"Cost-effectiveness of wound management in France: Pressure ulcers and venous leg ulcers","volume":"11","author":"Meaume","year":"2002","journal-title":"J. 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