{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T12:42:04Z","timestamp":1793104924979,"version":"4.5.0"},"reference-count":9,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2020,1,15]],"date-time":"2020-01-15T00:00:00Z","timestamp":1579046400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Medicina"],"abstract":"<jats:p>Background: To evaluate maternal and neonatal outcomes of assisted reproductive technology (ART). Materials and Methods: Pregnant women registered from 2015 through 2017 (n = 6994) at five perinatal centers that managed high-risk pregnancies in Mie, Japan, retrospectively. Rates of preterm birth (&lt;37 gestational weeks), early onset preeclampsia (&lt;34 gestational weeks), late onset preeclampsia (\u226534 gestational weeks), low-lying placenta, placenta previa, placenta accreta, placental abruption, atonic bleeding, uterine rupture, and amniotic fluid embolism after ART were evaluated. ART was defined as in vitro fertilization and micro-fertilization. Fisher\u2019s exact test, Mann\u2013Whitney\u2019s U test, and logistic regression analysis were used to analyze the data. Results: Rates of obstetrical complications including low-lying placenta, placenta previa, placenta accreta, and atonic bleeding were increased with ART compared to those with the control. Particularly, ART was associated with a significantly increased rate of placenta accreta (adjusted odds ratio: 7.35, 95% confidence interval (CI): 3.20\u201316.6) and significantly decreased rate of placental abruption (adjusted odds ratio: 0.24, 95% CI: 0.07\u20130.61). Conclusions: This study showed that ART may reduce placental abruption and increase placenta previa. There is a possibility that the placenta attaches deeper in the myometrium because of ART.<\/jats:p>","DOI":"10.3390\/medicina56010032","type":"journal-article","created":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T04:14:41Z","timestamp":1579234481000},"page":"32","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Evaluation of Maternal and Neonatal Outcomes of Assisted Reproduction Technology: A Retrospective Cohort Study"],"prefix":"10.3390","volume":"56","author":[{"given":"Hiroaki","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie 514-0008, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayo","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie 514-0008, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Osato","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie 514-0008, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideto","family":"Kusaka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie 514-0008, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Maegawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie 514-0008, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruki","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie 514-0008, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Ikeda","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie 514-0008, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,1,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/jog.13787","article-title":"Relationship between reproductive medicine for women with severe complications and maternal death in Japan","volume":"45","author":"Tanaka","year":"2019","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1093\/humrep\/deq117","article-title":"Obstetric outcomes after transfer of vitrified blastocysts","volume":"25","author":"Wikland","year":"2010","journal-title":"Humanit. Rep."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1016\/j.fertnstert.2009.12.027","article-title":"Blastocyst versus cleavage stage transfer in in vitro fertilization: Differences in neonatal outcome?","volume":"94","author":"Lindam","year":"2010","journal-title":"Fertil. Steril."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.fertnstert.2010.07.1075","article-title":"Perinatal outcome of singleton siblings born after assisted reproductive technology and spontaneous conception: Danish national sibling-cohort study","volume":"95","author":"Henningsen","year":"2011","journal-title":"Fertil. Steril."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.fertnstert.2011.12.032","article-title":"Outcomes of singleton births after blastocyst versus nonblastocyst transfer in assisted reproductive technology","volume":"97","author":"Fernando","year":"2012","journal-title":"Fertil. Steril."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.fertnstert.2012.09.044","article-title":"Matched-cohort comparison of single-embryo transfers in fresh and frozenthawed embryo transfer cycles","volume":"99","author":"Shapiro","year":"2013","journal-title":"Fertil. 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Steril."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.fertnstert.2013.09.025","article-title":"Impact of frozen-thawed single-blastocyst transfer on maternal and neonatal outcome: An analysis of 277,042 single-embryo transfer cycles from 2008 to 2010 in Japan","volume":"101","author":"Ishihara","year":"2014","journal-title":"Fertil. Steril."}],"container-title":["Medicina"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1648-9144\/56\/1\/32\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T13:19:49Z","timestamp":1760361589000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1648-9144\/56\/1\/32"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,15]]},"references-count":9,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,1]]}},"alternative-id":["medicina56010032"],"URL":"https:\/\/doi.org\/10.3390\/medicina56010032","relation":{},"ISSN":["1648-9144"],"issn-type":[{"value":"1648-9144","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,15]]}}}